Serum IgE and IgG antibody activity against Aspergillus fumigatus as a diagnostic aid in allergic bronchopulmonary aspergillosis.

• DOI: 10.1164/arrd.1978.117.5.917
• Publication Date: 1978-05-01
• Authors: Jianli Wang; R Patterson; Michael A. Rosenberg; M. C. Roberts; B. J. Cooper
• Keywords: Allergic bronchopulmonary aspergillosis; Radioallergosorbent test

Serum IgE and IgG antibody activity against Aspergillus fumigatus was measured in 3 groups of subjects by 2 different immunologic methods. Group A consisted 23 patients with allergic bronchopulmonary aspergillosis (ABPA). B composed 19 extrinsic asthma who had marked immediate type skin reactivity to A. (prick test, or 4+) but no other manifestation ABPA. C, the control group, 12 healthy subjects. Two immunological methods, including a solid-phase polystyrene tube radioimmunoassay an iodine-125-labeled, antigen radioimmunoassay, were used study each patient's serum sample, so as demonstrate (IgE-Af) (IgG-Af). Both IgE-Af IgG-Af significantly greater among than those both methods (P is less 0.001). The results this suggest that either method can be diagnostic aid for These may provide laboratory test permitting diagnosis ABPA its early stages before bronchial pulmonary destruction occurs.