Eighty-four patients with allergic bronchopulmonary aspergillosis (ABPA) were evaluated for a total of 294 patient-years mean observation period 3.7 years and classified by the stage ABPA. The largest percentage in IV (corticosteroid-dependent asthma stage) group. next V (fibrotic, end-stage lung disease) Of latter 24 patients, eight had died. In addition, we describe 13 all serologic characteristics ABPA but without central bronchiectasis. We propose that these have seropositive represent...

Serum IgE and IgG antibody activity against Aspergillus fumigatus was measured in 3 groups of subjects by 2 different immunologic methods. Group A consisted 23 patients with allergic bronchopulmonary aspergillosis (ABPA). B composed 19 extrinsic asthma who had marked immediate type skin reactivity to A. (prick test, or 4+) but no other manifestation ABPA. C, the control group, 12 healthy subjects. Two immunological methods, including a solid-phase polystyrene tube radioimmunoassay an...

Prostaglandins (PG) are cytoprotective for gastrointestinal epithelium, possibly because they enhance mucosal repair. The objective of the present studies was to assess role prostaglandins in intestinal Intestinal mucosa from porcine ileum subjected 1 h ischemia mounted Ussing chambers. Recovery normal transepithelial electrical resistance occurred within 2 h, and continued increase a further value twice that control. latter response blocked by inhibition prostaglandin synthesis, restored...

SUMMARY The oral glucose tolerance test in the horse provides an aid to diagnosis of pancreatic and small intestinal dysfunction. A dose ***1 g. glucose/Kg bodyweight is administered by stomach tube producing a peak level after two hours, which returns resting four hours later. Two horses with autopsy‐confirmed disease showing symptoms malabsorption gave “flat” curve. RÉSUMÉ Le de tolérance du par voie orale peut contribuer au diagnostic des troubles pancreas et l'intestin grêle. Une 1 gr...

Summary Amitraz, atropine, glycopyrrolate and morphine (but not its derivatives, meperidine [pethidine], oxymorphone butorphanol) produced similar effects on clinically observed intestinal functions significantly prolonged transit, as assessed with polyethylene glycol ( peg ). However, their mechanisms of action, particularly transport (fluid movement), may differ widely. Loperamide appeared to exert a preferential action rather than motility, there was no significant delay in transit. The...

OBJECTIVES: To report on the extent and nature of acute MDMA (ecstasy) related problems presenting to a large London hospital9s accident emergency (A&E) department. METHOD: The computerised attendance records for all patients attending A&E department over 15 month period were retrospectively screened. Potential cases thus identified had their case notes systematically reviewed confirm history use extract other relevant data. RESULTS: Forty eight consecutive identified. All in 15-30...

SUMMARY A 13‐year‐old Standardbred stallion presented with a unilateral mucopurulent nasal discharge and airway obstruction was found to have an extensive cryptococcal granuloma. Treatment not attempted. The destroyed 26 months later having completed 2 successful breeding seasons. granuloma had gradually increased in size almost completely occupied the left cavity paranasal sinuses. It characterised histologically by fibrous myxomatous tissue masses of yeasts. within wall jejunum could...

SUMMARY Three horses suffering from malabsorption were shown to have alimentary lymphosarcoma predominantly affecting the small intestine and associated lymph nodes. The diffuse cellular infiltration in two of cases produced marked changes villous architecture reducing available mucosal surface area, and, with lowered or barely detectable disaccharidase activities, contributed impairment digestive‐absorptive processes. One maintained a voracious appetite was not diarrhoeic, but failed gain...

Gastric contents were sampled in horses via nasogastric tube to determine changes pH and bile salt concentrations during feeding fasting periods. The rotated through 4 protocols. (1) hay; (2) hay with twice daily grain meals; (3) (4) preceded by either only or grain. Sequential, hourly samples collected from 3 prepared gastric cannulas. Horses fed mix small aliquots dispensed every 90 min. normal after 14 h of feed deprivation. values varied time, but there was no significant difference...

SUMMARY The effect of meal size and frequency on plasma volume, aldosterone concentration urinary Na K clearances was determined in ponies. A daily maintenance ration hay-grain pellets provided either as a multiple feeding regimen, ie, 12 equal portions fed at 2-hour intervals, or single large feedings, half the every hours 0800 2000 hours. Only morning studied, using latter regimen. Serial measurements volume were made by use an indicator-dilution technique indocyanine green (0.15 mg/kg...

SUMMARY A 4 month old foal with right sided maxillary enlargement and considerable upper airway obstruction had an ameloblastic odontoma in the sinus. This odontogenic tumour, probably congenital nature, extensively distorted structure contours of sinus, displaced adjacent turbinates nasal septum. RÉSUMÉ Un de mois présentait une hypertrophie du maxillaire supérieur droit avec marquée des voies respiratoires supérieures: ceci était provoqué par un odontome ameloblastique dans le sinus droit....

SUMMARY A D(+) xylose absorption test has been standardised for use in the horse. dose of 2 g. xylose/Kg. body‐weight is required to produce a maximum plasma level 30 mg./100ml. after two hours. There are limitations procedure being used as routine clinical screening small intestinal dysfunction RÉSUMÉ On standardisé un d'absorption du pour le cheval. Une de gr par kilo poids vif est nécessaire produire une élevation plasmatique jusqu'à mg 100 ml après deux heures. Il y des à l'emploi cette...

Summary Recent studies suggest that horses requiring surgical correction of strangulating intestinal obstruction may develop post operative complications as a result ischaemia/ reperfusion injury. Therefore, the mucosal and serosal margins resected small intestine from 9 with lesions were examined for evidence ischaemia/reperfusion Severe injury marked elevations in myeloperoxidase activity detected at ileal resection (n = 4), whereas mucosa proximal jejunal 9) distal 5) was normal. However,...

The relation of chronic bronchitis and respiratory dysfunction to age, tobacco smoking, occupational exposure surface underground mining operations were examined in a cross sectional survey 1363 men employed the Kalgoorlie industry 1985. Overall, prevalence was 14%. Eleven per cent workers had obstructive lung disorder (FEV1/FVC less than 0.70) 9% restrictive (FVC 0.80 predicted for height age). There little change from that observed same 1961-2. Only 1% 1985 radiographic signs silicosis...

Summary Colic was induced in horses and ponies following topical or intravenous (iv) administration of amitraz, a formamidine acaricide. The condition characterised by rapid cessation intestinal sounds, stasis, extensive impaction tympany throughout the large colon. Three animals that were necropsied had faecalith obstructing proximal small colon aboral to marked colonic impaction. A reproducible reversible colic syndrome could be an iv injection 1 mg amitraz/kg body weight solvent. There...

Lymphocytes having abundant cytoplasm and many azurophilic granules have been termed large granular lym- phocytes (LGL).2 Functionally, these cells natural killer (NK) antibody-dependent cell-mediated cytotoxic (ADCC) activity., Lymphoproliferative disorders of LGL reported in man, the rat, cat.2.3J0 The disease course is often chronic occurs older patients.z diseases are uncommon following case report describes an unusual tumor com- prised similar to adult horse. A 14-year-old castrated...

SUMMARY A Babesia parasite, isolated from the blood of a horse at Bowral, New South Wales, was identified on basis its morphological features, host specificity and serological reactions, as equi (Laveran 1901). The case originally reported by Churchill Best (1976, Aust Vet J 52 : 487) is first record equine babesiosis In Australia. preliminary studies, organism produced only mild disease in an intact horse, but caused typical clinical syndrome acute splenectomised which died 19 days after...

Progressive leukaemic changes and a persistent anaemia were demonstrated in the blood of 7 year old gelding, which had shown early signs lowered performance unthriftiness, later developed dependent oedema became dull listless. The total leucocyte count, initially within normal range although reflecting an absolute lymphocytosis, increased fourfold 6 days from excessive lymphoid production involving predominantly more immature cell types; lymphoblasts, prolymphocytes large lymphocytes....

SUMMARY The absorption of d‐xylose forms the basis a useful screening test in investigation small intestinal disorders horse. A comparison has been made different assay methods and there was no significant difference between results obtained with parabromoaniline (PBA) method or ferric chloride‐orcinol (FCO) method. orthotoluidine unsatisfactory. anticoagulant agent did not affect test. dose 0.5 g commercial grade xylose/kg body weight as 10 per cent solution given by stomach tube, produced...

Over a 3-year period, 1178 faecal samples were cultured from 462 horses admitted to the equine clinic of University Queensland; 185 positive for salmonella yielding 213 isolations consisting 21 serotypes. S. anatum was predominant serotype isolated (54%) followed by ohio (11.27%) and typhimurium (9.4%). One hundred ten (23.81%) on one or more occasion, 42 (9.09%) than occasion. most common (71.43%) main drains in stable block (33.57% samples). The prevalence excretors among large non-clinic...