Short term effects of coffee components consumption on gut microbiota in patients with non-alcoholic fatty liver and diabetes: A pilot randomized placebo-controlled, clinical trial.

• DOI: 10.17179/excli2019-2021
• Publication Date: 2020-01-01
• Authors: Asieh Mansour; Mohammad Reza Moh...; Sara Karimi; Milad Sanginabadi; Hossein Poustchi; Samaneh Enayati; Saeedeh Asgarbeik; Javad Nasrollahzadeh; Azita Hekmatdoost
• Keywords: Chlorogenic Acid

The aim of this study was to determine the effects caffeine and chlorogenic acid supplementation on gut microbiota, metabolic disturbances in patients with NAFLD diabetes. In randomized, placebo-controlled, clinical trial, 26 diabetes were randomly assigned four groups receive either 200 mg plus (CFCA), or placebo (starch) (CFPL), (CAPL), (PLPL) for 12 weeks. After 3 months supplementation, intervention showed a significant decrease body weight (CFCA group =-3.69 kg; CFPL group=-0.7kg; CAPL group=-0.43kg; PLPL group=0.26 kg) (p=0.004). Weight reduced significantly more CFCA compared all other three (p=0.005 PLPL; p=0.023 CAPL; p=0.031 CFPL). Although number Bifidobacteria increased group, there no statistically differences within between any bacteria numbers. conclusion, our that weeks consumption mg/day is effective reduction which might be at least partially through rise Bifidobacteria. This pilot shed light pathway future trials assessing coffee these patients. trial has been registered clinicaltrial.gov registration NCT02929901.