A coupled mitral valve—left ventricle model with fluid–structure interaction

• DOI: 10.17615/rzc4-rc60
• Publication Date: 2017-01-01
• Authors: Hao Gao; Liuyang Feng; Nan Qi; Colin Berry; Boyce E. Griffith; Xiaoyu Luo
• Keywords: Fluid–structure interaction

Understanding the interaction between valves and walls of heart is important in assessing subsequently treating dysfunction. With advancements cardiac imaging, nonlinear mechanics computational techniques, it now possible to explore valve-heart interactions using anatomically physiologically realistic models. This study presents an integrated model mitral valve (MV) coupled left ventricle (LV), with geometry derived from vivo clinical magnetic resonance images. Numerical simulations this MV-LV are developed immersed boundary/finite element method. The incorporates detailed valvular features, ventricular contraction, soft tissue mechanics, fluid-mediated MV LV wall. We use simulate function diastole systole, investigate how myocardial active relaxation affects pump function. results new agree measurements, demonstrate that diastolic filling pressure increases significantly impaired maintain normal output. has potential advance fundamental knowledge mechanisms underlying interaction, help risk stratification optimization therapies for diseases.