PERSPECTIVE DIRECTION OF USING FLAGELLIN BASED DRUGS

• DOI: 10.17816/maj1727-20
• Publication Date: 2017-06-15
• Authors: Г. А. Софронов; Г. А. Софронов; Elena V. Murzina; Elena V. Murzina; В. Н. Болехан; В. Н. Болехан; Olga M. Veselova; Olga M. Veselova; А. С. Симбирцев; А. С. Симбирцев
• Keywords: Flagellin; TLR5

This article reviews modern scientific literature devoted to the study of biological activity flagellin develop on its basis new effective medicines. One most promising areas research is use recombinant as adjuvant in vaccines against causative agents different infectious diseases first all influenza. The characteristics recent containing and data immunogenicity studies hybrid molecules are presented. Several influenza developed by VaxInnate Corporation (USA) undergo phases clinical trials. effectiveness Russian (Russian Institute influenza) currently being studied animals. second important direction based radioprotective properties flagellin. Currently world there one drug entolimod (Cleveland BioLabs, USA), which efficiency was experiments mice primates. overview analyzed mechanisms action drugs a TLR5 agonists presented authors. Also results researches proving potential derivatives radiation countermeasure reviewed.