A5015251602- Effects of Radiation Exposure
- Radiopharmaceutical Chemistry and Applications
- Anesthesia and Neurotoxicity Research
- Hemoglobin structure and function
- Antioxidants, Aging, Portulaca oleracea
- Chemical Thermodynamics and Molecular Structure
- Crystallization and Solubility Studies
- Neuroscience and Neuropharmacology Research
- Plant-based Medicinal Research
- Chemical and Physical Studies
- Fluorine in Organic Chemistry
- Cancer Cells and Metastasis
- Chemical Reactions and Isotopes
- Mesenchymal stem cell research
- Polysaccharides and Plant Cell Walls
- Analytical Chemistry and Chromatography
- Immunotoxicology and immune responses
- Medical History and Innovations
- Curcumin's Biomedical Applications
- Phytoestrogen effects and research
- Spaceflight effects on biology
S. M. Kirov Military Medical Academy
2017-2024
Sechenov University
2004
The relevance is determined by the need to develop new means of antiradiation protection, which could be used for irradiating people in case emergency situations or medical use ionizing radiation diagnostic therapeutic purposes. Aim: evaluate prospects beta-D-glucan as a candidate drug development pharmacological reduce toxic effects exposure. Materials and methods. In experiments on male mice protective effect derived from Pleurotus ostreatus mushroom parameters 30-day survival irradiated...
This article reviews modern scientific literature devoted to the study of biological activity flagellin develop on its basis new effective medicines. One most promising areas research is use recombinant as adjuvant in vaccines against causative agents different infectious diseases first all influenza. The characteristics recent containing and data immunogenicity studies hybrid molecules are presented. Several influenza developed by VaxInnate Corporation (USA) undergo phases clinical trials....
BACKGROUND: There is a high need for drugs to reduce the side effects of radiation exposure on people in extreme, military, marine, space medicine, at nuclear facilities, hematology and oncology. AIM: To evaluate antiradiation efficacy beta-D-glucan derived from Oyster mushroom (Pleurotus ostreatus) after total body irradiation mice terms survival hematopoiesis. MATERIALS AND METHODS: The study was conducted mouse model acute hematopoietic syndrome caused by X-rays. Radioprotective effect...
The therapeutic effect of fibroblast-like cells obtained from the stromal vascular fraction subcutaneous adipose tissue mice and cultured for treatment bone marrow form acute radiation syndrome was studied on a mouse experimental model. were identified as multipotent mesenchymal stem (stromal) cells, owing to adhesion plastic, confluent monolayer formation during cultivation, fact that osteogenic differentiation in vitro resulted osteoblast maturation calcium deposit formation, which...
Objective: to estimate the perfluorane adsorption capacity of drugs belonging different pharmacological groups. Materials and methods. The binding 50 at concentrations 12.5 100 ^M was studied in vitro using equilibrium dialysis. Results. Interactions ligands with particles emulsion were found be three types. Type 1 substances characterized by negative affinity perfluorane; type 2 acted indifferently emulsion; 3 compounds reversibly adsorbed blood substitute constants ( Kaff) 104 M-1....
Introduction. A new experimental approach to channel blockers verapamil and ketamine use in treatment of malignant brain gliomas was elaborated on highly invasive rat glioma strain 101.8 taking into consideration influence pathogenic mechanism ionotropic NMDA-receptors mediated through blood cells aggregation.Materials methods. Effects different dilutions (10-1-10-6) aggregation were studied 312 patients with neurosurgical diseases 15 Wistar rats. Experimental testing the method performed 70...
Research objective. To evaluate the radioprotective effectiveness of recombinant flagellin when used alone or in combination with interleukin-1 beta for prophylactic therapeutic effect on animals. Materials and methods. The hybrid FliC Salmonella typhimurium human interleukin-1β (Institute Highly Pure Biopreparations, Saint Petersburg, Russia) 30-day survival male mice exposed to lethal doses X-ray radiation was studied. Survival irradiated animals analyzed by Kaplan-Meier method. Results....
Cellular therapy of hematopoietic acute radiation syndrome is currently at the forefront scientific interest due to high regenerative potential stem cells, their anti-inflammatory and antifibrotic effects. Stem cells have a ability stimulate proliferation differentiation cells. It has been shown that after administration are able migrate lesions under influence chemotactic factors. At same time, they retain functions can differentiate into affected tissues contribute recovery.
 The...
This paper presents the history of formation Research Department Experimental Medicine Center Military Medical Academy named after S.M. Kirov. The department is only division academy that conducts experiments on animal models and field tests using laboratory animals in interests Armed Forces Russian Federation. also main scientific achievements development prospects one three laboratories Laboratory Medicinal Environmental Toxicology. In direction drug toxicology, staff worked for 15 years...