EVALUATION OF THE ANTIOXIDATIVE, ANTIDIABETIC AND ANTILIPIDEMIC EFFECT OF BITTER MEL ON SEEDS (CITRULLUS COLOCYNTHIS) ALCOHOLIC EXTRACT ON FEMALE RATS

• DOI: 10.21608/absb.2010.7351
• Publication Date: 2018-05-21T04:22:03Z
• Authors: Asadatun Abdullah; Sayed Bakry; Abeer Abd ElBaky; Alfred Mansour
• Keywords: Citrullus colocynthis; Hyperlipidemia; Citrullus; Alloxan

Background: Diabetes mellitus and hyperlipidemia are well-known risk factors for several illnesses including atherosclerosis, heart vascular diseases stroke. Herbal medicine is still the mainstay of about 75–80% world population, mainly in developing countries, primary health care because better cultural acceptability, compatibility with human body lesser side effects. extracts introduced to mankind since many centuries, herbal different oral formulas have been recommended diabetes treatment all over world. Objective: The present study was carried out investigate hypoglycemic, hypolipidemic antioxidative effects extract Bitter melon (Citrullus colocynthis) young adult Sprague Dawley female rats eight weeks. Materials Methods: Forty were divided into two sections. Section I (Normal animals) S.C. injection a vehicle (0.9% NaCl) groups (10 / group), one these served as control group second received seed 50 mg/kg/day 8 weeks normal treated group. Group II Alloxan (diabetic rats) each), diabetic while Citrullus colocynthis (C-colocynthis) (50mg/kg/day) orally After 8-weeks experiment terminated animals sacrificed, blood drawn sera separated assessment glucose, lipid profile, peroxidation value (MDA), reduced glutathione (GSH), lactate dehydrogenase (LDH), alanine transaminase (ALT), aspartate (AST), alkaline phosphatase (ALP) well total direct bilirubin. Results: Both showed significant decrease cholesterol (TC), triglycerides (TG) While, levels significantly increased both normoglycemic hyperglycaemic except ALT, AST ALP had no changes. Conclusions: shed more light on effect proves that this has antioxidant, hypoglycemic properties may be used treating mellitus.