A5018470227- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Mesenchymal stem cell research
- Reproductive Health and Technologies
- Tissue Engineering and Regenerative Medicine
- Growth Hormone and Insulin-like Growth Factors
- Assisted Reproductive Technology and Twin Pregnancy
- Carcinogens and Genotoxicity Assessment
- Photoreceptor and optogenetics research
- Metabolism and Genetic Disorders
- Biochemical and Molecular Research
- Heavy Metal Exposure and Toxicity
- Electrospun Nanofibers in Biomedical Applications
- Advanced Chemical Sensor Technologies
- Biosensors and Analytical Detection
- Reproductive Health and Contraception
- Effects and risks of endocrine disrupting chemicals
- Mitochondrial Function and Pathology
- Birth, Development, and Health
- Bone and Joint Diseases
- Menstrual Health and Disorders
- Ovarian function and disorders
- Reproductive System and Pregnancy
- Hormonal and reproductive studies
- Rheumatoid Arthritis Research and Therapies
Al-Azhar University
2013-2025
Sohag University
2025
Al-Azhar University
2007-2024
Cairo University
2015
New York University
2007-2008
Maimonides Medical Center
2007
St George's Hospital
2006
Abstract Burn injuries pose a significant healthcare burden worldwide, often leading to long-term disabilities and reduced quality of life. To explore the impacts transplantation mesenchymal stem cells (MSCs) on healing burns levels serum cytokines, 60 fully grown Sprague–Dawley rats were randomly divided into three groups ( n = 20 each): group I (control), II (burn induction), III induction + bone marrow (BM)-MSC transplantation). Groups further four subgroups 5 each) based euthanasia...
Abstract Objective Premature ovarian insufficiency (POI) is a significant reproductive health concern characterized by the depletion of primary follicles, often resulting from exposure to genotoxic agents. This study aimed explore therapeutic potential bone marrow-derived mesenchymal stem cells (BM-MSCs) and/or placental extracts (PE) in ameliorating POI induced cyclophosphamide, widely used chemotherapeutic agent. Materials and methods Thirty-five 8–10 weeks weight 200 ± 20 g female albino...
Lithocholic acid (LCA) is a secondary bile that selectively toxic to human neuroblastoma, breast and prostate cancer cells, whilst sparing normal cells. We previously reported LCA inhibited cell viability proliferation induced apoptosis necrosis of androgen-dependent LNCaP androgen-independent PC-3 In the present study, we investigated roles endoplasmic reticulum (ER) stress, autophagy mitochondrial dysfunction in toxicity deficient, DU-145 ER stress-related proteins, such as...
Bioactive compounds extracted from marine organisms showed several biological activities. The present study is an extension of our earlier studies where we assessed the antiproliferative and pro-apoptotic activities ethanol, methylene chloride, ethyl acetate, acetone, chloroform crude extracts sponges: Negombata magnifica (NmE) Callyspongia siphonella (CsE) against cancer cells. Herein, are extending previous findings on both sponge species depending alternative methanol extraction method...
ObjectiveAutologous fat graft injection to the soft palate is a relatively new treatment for velopharyngeal insufficiency (VPI). This study aimed at evaluating outcome following into and speech therapy in selected patients determine good candidates.DesignRetrospective case series.SettingInstitutional tertiary hospital.PatientsThe included 22 with VPI associated repaired cleft (CP), submucous cleft, or post-adenoidectomy. The inclusion criteria were mild moderate hypernasality closure > 50%....
Background: Non-obstructive azoospermia (NOA) represents an infertility problem that is usually difficult to treat. Such patients have testicular biopsy of germ cell aplasia or spermatogenic arrest. In recent decades, mesenchymal stem cells (MSCs) had been studied thoroughly and proved safe effective regarding their capability for trans-differentiation into different types. The aim this study was evaluate the effect MSCs local intratesticular injection in induction spermatogenesis. Patients...
Depo Provera®; (Medroxyprogesterone Acetate, DMPA) is a longacting,injectable progesterone derivative contraceptive that currently used by 30 million women in 90 countries, including Egypt, United States and Canada. DMPA classified as sex hormone binding globulin (SHBG). The objective of this study was to investigate body weight serum lipid profile following treatment rats with the injectable depot medroxyprogesterone acetate, (Depo DMPA). Adult female (Rattus norvigcus) were treated single...
Bisphenol A (BPA) is an industrial chemical, used to manufacture polycarbonate and numerous plastic articles leach salt fresh water.Low levels of BPA have also been found cause biological effects, its mode action appears mimic that the female hormone, estrogen.BPA therefore belongs a group chemicals termed "hormone disruptors" or "endocrine are able disrupt chemical messenger system in body.The present study aimed assess histological changes caused kidney tissues both mosquito-fish (Gambusia...
The role of hyaluronic acid (HA) as a 'physiologic selector' is also well recognized in vitro: it has been demonstrated that spermatozoa bind to immobilized HA vitro are those having completed their plasma membrane remodelling, and cytoplasmic meiotic maturation. Sperm selection using expected increase the implantation rate intracytoplasmic sperm injection (ICSI) cycles. This work was designed evaluate an alternative product for slowing motility contains measures its outcomes: fertilization...
Purpose: to assess safety and efficacy of autologous mesenchymal bone marrow stem cell injection in penile cavernosal tissue for erectile dysfunction therapy diabetic men. Methods: The subjects this study were men suffering dysfunction, non-responding maximum dose oral PDE5I. Mesenchymal cells aspirated injected after preparation both corpora cavernosa at 3, 9 o’clock position. Erectile function was assessed by the International Index Function Doppler study, before 6 months injection....
Background: Diabetes mellitus and hyperlipidemia are well-known risk factors for several illnesses including atherosclerosis, heart vascular diseases stroke. Herbal medicine is still the mainstay of about 75–80% world population, mainly in developing countries, primary health care because better cultural acceptability, compatibility with human body lesser side effects. extracts introduced to mankind since many centuries, herbal different oral formulas have been recommended diabetes treatment...
Syzygium Aromaticum (clove) and Nigella sativa (black seed), traditional medicinal herbs, display broad anticancer activity.The observations supported these oils' anti-proliferative cytotoxic activities by MTT assay.The cold-pressed extracted oil was evaluated against cervical (HeLa), pancreatic (Panc), colon (HCT) carcinoma cells compared to doxorubicin.Clove had the lowest IC 50 values HeLa, HCT, Panc cells, which were 0.25, 0.38, 5.26 µg/ml, respectively.Black seed next, with of about...