A5051434468- Hepatitis B Virus Studies
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Immune responses and vaccinations
- Hair Growth and Disorders
- Hemoglobinopathies and Related Disorders
- Immune cells in cancer
- Asthma and respiratory diseases
- Virus-based gene therapy research
- Chronic Kidney Disease and Diabetes
- Diabetes and associated disorders
- Dermatology and Skin Diseases
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Bone Metabolism and Diseases
- Vagus Nerve Stimulation Research
- Long-Term Effects of COVID-19
- Liver physiology and pathology
- Adrenal Hormones and Disorders
- Sexuality, Behavior, and Technology
- Helicobacter pylori-related gastroenterology studies
Al-Azhar University
2022-2025
Cairo University
2025
Al-Azhar University
2014-2024
Osol Aldeen University College
2024
Al-Nisour University College
2024
Assiut University Hospitals
2024
Chest Diseases Hospital
2023
Zagazig University
2022
Assiut University
2021
Nasser Institute hospital
2008-2017
Hematopoietic stem cells (HSCs) and hematopoietic progenitor (HPCs) play a crucial role in the context of viral infections their associated diseases. The link between HSCs HPCs disease status COVID-19 patients is largely unknown. This study aimed to monitor kinetics contributions severe non-severe evaluate diagnostic performance differentiating healthy as well cases. Peripheral blood (PB) samples were collected from 48 patients, 16 recovered, 27 controls subjected deep flow cytometric...
Background: Central vein occlusion (CVO) is a frequent complication in end-stage renal disease (ESRD) patients undergoing regular hemodialysis (HD). Percutaneous transluminal angioplasty (PTA), with or without stenting, has become the primary treatment method for this condition.Objective: To evaluate effectiveness and safety of PTA, treating CVO patients.Patients Methods: This prospective study included 30 ESRD on who exhibited symptoms venous hypertension such as arm facial edema, painful...
Acute kidney injury (AKI) is a word that refers to loss of renal function occurs suddenly and accompanied with an elevated creatinine levels in the blood (a sign) decreased urinary output (oliguria) quantitative metric urine production), 7-day limit. Risk factors for AKI include environmental, socioeconomic and/or cultural factors, as well related process care, acute exposures patients themselves. Since Stem cell has immense potential regenerative cellular therapy. Mesenchymal stem cells...
Abstract Background Alopecia areata (AA) is a common inflammatory disorder targeting the hair follicles leading to non-scaring loss. The pathogenesis of AA still unclear, despite accumulating evidence immune-mediated nature this disease. So, in study, we aimed assess level CD4 T cells, CD8 cells and natural killer (NK) peripheral blood patients with active control subjects, evaluate association between those duration disease different subtypes AA. Results Fifty female 50 age- sex-matched...
Human SARS-CoV-2 and avian infectious bronchitis virus (IBV) are highly contagious deadly coronaviruses, causing devastating respiratory diseases in humans chickens. The lack of effective therapeutics exacerbates the impact outbreaks associated with IBV infections. Thus, novel drugs or therapeutic agents demand for controlling viral transmission disease progression. Mesenchymal stem cells (MSC) secreted factors (secretome) safe efficient alternatives to MSC-based therapies. This study aimed...
The immune response implicated in Coronavirus disease 2019 (COVID-19) pathogenesis remains to be fully understood. present study aimed clarify the alterations CD4+ and CD8+ memory T cells’ compartments SARS-CoV-2-infected patients, with an emphasis on various comorbidities affecting COVID-19 patients. Peripheral blood samples were collected from 35 16 recovered individuals, 25 healthy controls, analyzed using flow cytometry. Significant detected percentage of cells effector memory-expressing...
Several studies were performed to evaluate the degree of liver fibrosis by non-invasive markers. We aimed assess diagnostic value both biglycan (BGN) and osteopontin (OPN) as markers hepatic in patients with chronic hepatitis B (CHB) C (CHC). This study was on 100 CHB virus, CHC virus normal controls. All participants subjected following laboratory tests: hemoglobin, platelet, alanine aminotransferase, aspartate albumin, international normalized ratio, HBs Ag, (HCV) antibody, DNA, HCV RNA,...
Psoriasis vulgaris (PsV) is an immune-mediated inflammatory disorder with devastating psychosocial consequences. Expression of immunoregulator molecules on leukocytes in PsV remains unclear. Leukocyte-associated Ig-like receptor-1 (LAIR-1) and complement (CR-1) are receptors reported to bind component 1q involved phagocytosis. We aimed explore if altered leukocyte expression LAIR-1 CR-1 associated PsV. This case–control study included 36 patients healthy controls. Neutrophils, monocytes B T...
Objectives: The aim of this study is to assess the level myeloid-derived suppressor cells (MDSCs) and expression costimulatory molecules CD80 CD86 on monocytes their ligands (CD28) T-lymphocytes in children with allergic rhinitis (AR). Methods: included 60 AR 50 controls. Flow cytometry was performed analyze MDSCs T-lymphocytes. Results: percentages total monocytic molecule were significantly higher than healthy In addition, expressions CD28 CD4 + CD8 elevated patients. Conclusion: present...
Purpose: to assess safety and efficacy of autologous mesenchymal bone marrow stem cell injection in penile cavernosal tissue for erectile dysfunction therapy diabetic men. Methods: The subjects this study were men suffering dysfunction, non-responding maximum dose oral PDE5I. Mesenchymal cells aspirated injected after preparation both corpora cavernosa at 3, 9 o’clock position. Erectile function was assessed by the International Index Function Doppler study, before 6 months injection....
Infections with the Toxoplasma gondii parasite (T.gondii) occur worldwide and affect about one third of humanity.The study determined prevalence T. among primigravidae Women vertical transmission T in their newborns.Socio-demographic data potential predisposing risk factors were studied using structured questionnaire.Venous blood samples (350 samples) collected tested for IgM & IgG anti-Toxoplasma antibodies by enzymelinked immunosorbent assay (ELISA) during pregnancy period at birth...
Background: We aimed to monitor the phenotypic changes in macrophages and their polarization patients with acute viral respiratory diseases, including coronavirus disease diagnosis, focusing on variations percentages of monocytes sub-populations those compared healthy control. Moreover, we defined correlation between macrophage subtypes some inflammatory indices. Methods: Twenty-seven clinical radiologic diagnosis infection admitted Al-Azhar Assiut University hospitals were recruited. Fresh...
Surgical site infection (SSI) is a serious postoperative complication after cardiac surgery. The objective of this research to examine the efficacy administering gentamicin in minimizing incidence SSI while closely monitoring therapeutic level drug. Prospective included 50 Iraqi patients divided into two groups, 25 each: Group 1 received combination flucloxacillin and ceftriaxone, 2 mg/kg ideal body weight given before surgery, then 80 mg*3 for 48 hours A total five had an at surgical site,...
Background and aim Knee osteoarthritis (OA) is a common chronic condition resulting in pain, fatigue, functional limitations, increased healthcare utilization, high economic costs to society. Therefore, this study aims assess the role of T memory cells pathogenesis knee OA. Patients methods This case–control was carried out on 30 symptomatic patients with radiographic evidence OA, who were attending Al-Azhar University Hospital, Assuit healthy volunteers. All included subjected examination,...
Background Dermatomycosis affects millions of people worldwide; the availability data on prevalence superficial fungal infections and some associated epidemiological factors in our region is little. Objective To compare conventional molecular methods to characterize species causing human mycotic infection. Patients The present cross-sectional study skin diseases was done 100 patients. Skin scrapings nail cuttings were subjected direct microscopic examination using potassium hydroxide...
We aimed to quantify monocyte subsets in newly diagnosed pediatric patients with solid tumors at South Egypt Cancer Institute (SECI) and Assiut University Hospital (AUH), investigate their roles the treatment outcomes.This is a prospective case-controlled study included 100 de novo forty age sex matched healthy children provide blood samples as control subjects determine normal count of subsets, were collected from cancer before first cycle chemotherapy, these subjected routine laboratory...
Abstract Background Hepatitis B virus (HBV) may reactivate when treating chronic hepatitis C (CHC) with direct-acting antivirals (DAA). We aimed to investigate the risk of HBV infection and reactivation during DAA therapy by performing a prospective observational study carried on 200 patients positive for HCV who were candidates treatment according Egyptian guidelines from February 2019 December 2019; identified carry HBsAg at baseline or HBc Abs further assessed other markers: e antigen...
Background: Approximately one-third of the world's population is exposed to hepatitis B virus infection, where 400 million are chronically infected.Approximately 25% those infections at risk for mortality due chronic liver disease or hepatocellular carcinoma (HCC).In Egypt, prevalence rate HBV 1.4% in adults aged 15-59 years old mainly higher Upper Egypt (Aswan, Assiut, and Minya Governorates).Objective: Our study aims demonstrate occult infection (OBI) among a randomly selected sample...