Hypofractionated Postoperative IMRT in Prostate Carcinoma: A Phase I/II Study

• DOI: 10.21873/anticanres.12025
• Publication Date: 2017-10-07T09:18:23Z
• Authors: Gabriella Macchia; G. Siepe; I. Capocaccia; Nam P. Nguyen; Riccardo Schiavina; S. Cammelli; Sara Guerri; A. Arcelli; Milly Buwenge; M. Ntreta; Savino Cilla; Vincenzo Valentini; Francesco Deodato; A.G. Morganti
• Keywords: Male; Prostatectomy; Time Factors; Adjuvant; Hypofractionation; IMRT; Phase I-II; Prostate neoplasms; Radiotherapy; Aged; Androgen Antagonists; Chemoradiotherapy, Adjuvant; Disease-Free Survival; Humans; Kallikreins; Kaplan-Meier Estimate; Male; Middle Aged; Prospective Studies; Prostate-Specific Antigen; Prostatic Neoplasms; Radiotherapy, Intensity-Modulated; Time Factors; Treatment Outcome; Dose Hypofractionation; Prostatectomy; Oncology; Cancer Research; Prostatic Neoplasms; Androgen Antagonists; Chemoradiotherapy, Adjuvant; Kaplan-Meier Estimate; Middle Aged; Prostate-Specific Antigen; Disease-Free Survival; 3. Good health; Adjuvant; IMRT; hypofractionation; phase I-II; prostate neoplasms; radiotherapy.; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Humans; Kallikreins; Radiation Dose Hypofractionation; Prospective Studies; Radiotherapy, Intensity-Modulated; Aged

Aim: To report the outcome of hypofractionated radiotherapy after radical prostatectomy (RP) for prostate cancer (PCa) using simultaneous integrated boost-intensity modulated radiation therapy (SIB-IMRT). Patients and Methods: A total 124 patients with PCa at high risk relapse RP or diagnosis biochemical were included. received 62.5 Gy to bed 45 pelvic nodes in 25 fractions. Androgen-suppressive was prescribed based on National Comprehensive Cancer Network categories. Results: Median follow-up 30 months. Only two (1.6%) developed grade 3 more acute toxicity: one skin toxicity (0.8%) 4 genitourinary (0.8%). Grade 2 gastrointestinal recorded 24.2% 17.7% patients, respectively. Five-year 1.1% 7.3%, relapse-free survival 86.5%. Conclusion: After RP, IMRT-SIB demonstrated a favorable profile encouraging results terms survival.