Effect of kebar grass extract ( Biophytum petersianum Klotzsch) on histopathological changes in liver of mice offspring from the parent exposed to carbofuran during lactation period

• DOI: 10.24425/pjvs.2021.139982
• Publication Date: 2023-07-20T19:01:34Z
• Authors: N A Yulitasari; Sri Hidanah; Widjiati Widjiati; Viski Fitri Hendr...; Epy Muhammad Luqman
• Keywords: Carbofuran; Median lethal dose; Intraperitoneal injection

This study aims to determine the potential of Kebar grass extract in reducing impact liver damage mice offspring ( Mus musculus) from parent exposed carbofuran during lactation period. 42 used were divided into seven groups, each group consisting six mice. Carbofuran, extract, and vitamin C are administered orally on days 1 14 after birth. consisted K (aquadest), P1 (carbofuran 1/4 LD50 0.0125 mg/day), P2 1/8 0.00625 P3 (Kebar 3.375 mg (0.2 ml) + LD50), P4 P5 (vitamin 5 P6 LD50). On 15th day birth, sacrified their taken for microscopic examination with hematoxilin eosin staining. The scoring data analyzed using Kruskal-Wallis Mann-Whitney test. result showed significant different (p⟨0.05) among treatment groups. Mean degeration is (1.13), necrosis (1.13) inflamation (0.73), while mean degeneration (2.20), (2.73) (1.93). conclusion this research giving more effective degeneration, inflammatory cell's infiltration than