Effect of a mixture of inulin and fructo-oligosaccharide on Lactobacillus and Bifidobacterium intestinal microbiota of patients receiving radiotherapy: a randomised, double-blind, placebo-controlled trial.

• DOI: 10.3305/nh.2012.27.6.5992
• Publication Date: 2013-04-17
• Authors: Pilar García-Peris; C. Velasco; M.A. Lozano; Yolanda Moreno; L Paron; Cristina Cuerda; Irene Bretón Lesmes; M. Camblor; Jorge García‐Hern...; Francisco Guarner; Manuel Hernández
• Keywords: Prebiotic; Lactobacillus gasseri

The pathogenesis of enteritis after abdominal radiotherapy is unknown, although changes in faecal microbiota may be involved. In several studies, Lactobacillus and Bifidobacterium have proven beneficial for the host. Prebiotics stimulate proliferation Bifidobacterium, this positive effects on intestinal mucosa during radiotherapy.We performed a randomised double-blind, placebo-controlled trial including 31 patients with gynaecological cancer who received (29 sessions, 52.2 Gy) surgery. Patients were to two groups: prebiotic placebo. first group mixture fibre (50% inulin 50% fructo-oligosaccharide) second 6 g maltodextrin twice daily from one week before three weeks radiotherapy. counts determined faeces samples (day -7 radiotherapy, day 15 at end treatment, radiotherapy) by culture selective media fluorescent situ hybridization (FISH) using genus-specific probes. Bacterial FISH significantly higher than method.There no differences baseline between groups. At we observed statistically significant decrease both By cultural analysis, numbers (5.6 vs. 6.3, p = 0.04 5.5 log cfu/g, 0.03).Abdominal negatively affects counts. fructoligosaccharide can improve recovery genera Registered under ClinicalTrials.gov Identifier no. NCT01549782.