Study on delineation of gross tumor volume (GTV) of primary locally advanced nasopharyngeal carcinoma after induction chemotherapy

• DOI: 10.3760/cma.j.issn.0254-5098.2016.02.007
• Publication Date: 2016-02-25
• Authors: Xiuyun Gong; Feng Jin; Weili Wu; Jia-ying Gan; Yuanyuan Li; Jinhua Long; Xiaoxiao Chen; Limin Wang

Objective To investigate the delineation primary lesions of gross tumor volume (GTVnx) in locally advanced nasopharyngeal carcinoma (LANC).

Methods During 2012–2013, 52 patients with LANC treated two-three cycles induction chemotherapy accepted CT simulation and MRI scans same treatment position. All images T1W1 sequence were collected transmitted to planning system. The target was delineated through images. Meanwhile, metastatic lymph nodes, CTV1, CTV2 organs at risk(OAR) alone. from then fused as MRI/CT fusion by radiotherapy system, prescription dose limitation OAR given changes GTVnx, radiation dose, coverage normal two different compared.

Results The image [(43.14±28.40 cm3)] larger than [(40.09±27.04) cm3] (t=3.791, P<0.001). And there statistical difference between GTV before after IC, (27.90±11.86) [(30.64±11.86) cm3](t=3.948, P<0.001), respectively. [(41.71±26.86) [(38.65±25.66) (t=4.098, But no differences images.

Conclusions The technique can increase radicalized may decrease possibility leaving out definition.

Key words: Locally carcinoma; Induction chemotherapy; MRI/CT image; Target