A5100724929- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Spaceflight effects on biology
- Circadian rhythm and melatonin
- Brain Metastases and Treatment
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Stress Responses and Cortisol
- MRI in cancer diagnosis
- Effects of Radiation Exposure
- Inflammation biomarkers and pathways
- Inflammasome and immune disorders
- Gastrointestinal motility and disorders
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Plasmonic and Surface Plasmon Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Medicinal Plant Pharmacodynamics Research
- Cancer-related gene regulation
- Neurogenesis and neuroplasticity mechanisms
- Chemokine receptors and signaling
- Neural dynamics and brain function
- Galectins and Cancer Biology
Guiyang Medical University
2016-2025
Affiliated Hospital of Guizhou Medical University
2016-2025
Shandong Normal University
2025
Soochow University
2024
Tianjin Medical University
2020
Central South University
2020
Nanjing Tech University
2020
Shanghai Center For Bioinformation Technology
2008-2019
Guizhou Cancer Hospital
2012-2019
Nanjing Medical University
2019
Ferulic acid (FA) is a derivative of cinnamic acid. It used in the treatment heart head blood-vessel disease and exerts protective effects against hypoxia/ischemia-induced cell injury brain. This study investigated potential neuroprotective FA ischemia/reperfusion (I/R)-induced brain vivo vitro through hematoxylin eosin (H&E) Nissl staining assays, flow cytometry, Hoechst 33258 staining, quantitative PCR, western blot analysis fluorescence microscopic analysis. In this study, models cerebral...
Abstract Engrailed-2 (EN2), a member of the engrailed homeobox family, has been shown to be abnormally expressed in variety cancers. However, expression and clinical significance EN2 colorectal cancer (CRC) are largely unknown. Firstly, we found that acted as an oncogene CRC. was upregulated tissues compared with adjacent normal tissues. Higher significantly associated poorer survival rate. Knockdown markedly inhibited proliferation migration capacities SW480 cells vitro, suppressed...
Purpose: Analyze the incidence and risk factors of thyroid dysfunction in patients with advanced nasopharyngeal carcinoma (LA-NPC) after intensity-modulated radiotherapy (IMRT) PD⁃1 inhibitor treatment their relationship efficacy prognosis. Methods: Eighty-five LA-NPC treated IMRT PD-1 inhibitors were retrospectively collected from March 1, 2019, to May 30, 2022. The combination therapy was analyzed. Kaplan–Meier method used analyze between patient Logistic regression analysis screen...
BMAL1 is a core circadian clock gene that expressed rhythmically in variety of tumor cells and related to cancer cell proliferation chemoradiotherapy sensitivity. Radiotherapy plays an important role the treatment nasopharyngeal carcinoma (NPC). However, rhythmicity NPC, as well its precise radiotherapy, remains unclear. We assessed changes expression over 48 h NPC normal epithelial NP69 using real-time quantitative polymerase chain reaction (RT-PCR) western blotting (WB). Then, we induced...
Aging | doi:10.18632/aging.205563. Chaofen Zhao, Lina Liu, Qianyong He, Yuanyuan Li, Jianglong Feng, Yue Chen, Yuxin Xinyu Xu, Shaoyuan Zhu, Yuanmei Ye, Yajing Wen, Zhirui Zeng, Ding'an Zhou, Feng Jin
The present study comprised a series of experiments to investigate the mechanism underlying effect ginsenoside on self-renewal, proliferation and differentiation neural stem cells (NSCs) undergoing oxygen-glucose deprivation/reperfusion (OGD/R) in vitro. NSCs, which were isolated from hippocampus embryonic day 17 embryo rats, subjected OGD/R establish an vitro model brain ischemia-reperfusion, following different doses administered model. NSCs was determined using MTT colorimetry...
We investigated the relationship between head and neck squamous cell carcinoma (HNSCC) mRNA protein expression levels of circadian genes Period (Per) family, Per1, Per2 Per3. Tissue sections HNSCC normal tissues from two patient cohorts different hospitals were collected to assess expressions three Per family using real-time quantitative PCR (RT-PCR) immunohistochemistry (IHC). The clinicopathological features disease prognosis for latter cohort analyzed through IHC statistical methods....
Abstract Background Anxiety is a common disorder with high social burden worldwide. Dysfunction of serotonin‐ 1A receptor (5‐HT receptor) in the dentate gyrus (DG) hippocampus has been predominantly implicated anxiety behavior. However, molecular mechanism underlying deficiency postsynaptic 5‐HT regulating behavior remains unclear. Methods Using pharmacological and genetic methods, we investigated role detate nNOS decline induced by chronic mild stress (CMS) mice. Results Here showed that...
Circadian clocks are endogenous time-keeping systems that temporally organize biological processes. Gating of cell cycle events by a circadian clock is universal observation currently considered mechanism serving to protect DNA from diurnal exposure ultraviolet radiation or other mutagens. In this study, we put forward another possibility: such gating helps insulate the perturbations induced transcriptional inhibition during M phase cycle. We introduced periodic pulse into previously...
Non-typhoidal
To investigate the involvement of circadian clock gene BMAL1 in regulating radiosensitivity nasopharyngeal carcinoma (NPC). The regulatory role NPC radiotherapy was investigated using 44 cases and cell line CNE2, which had been genetically modified to either overexpress or silence BMAL1. Infected CNE2 cells were divided into four groups, including those with overexpression RNA interference (RNAi), as well their respective control groups. group responses different doses examined. 5-year...
e18003 Background: This study aimed to evaluate 5-year outcomes and the late toxicity profile of chrono-chemotherapy with different infusion rates in patients locally advanced nasopharyngeal carcinoma (NPC). Methods: Our retrospective analysis included 70 NPC stages III IVB (according 2010 American Joint Committee on Cancer staging system). Patients were treated two cycles induction chemotherapy (IC) before concurrent chemoradiotherapy (CCRT) at affiliated cancer hospital Guizhou medical...
Objective To assess the antiangiogenic role of recombinant human endostatin combined with chemoradiotherapy and capacity, to explore early tumor response as measured by comparing change MRI perfusion parameter. Methods From May 2012 March 2013, 22 locally advanced nasopharyngeal carcinoma patients who received following induction chemotherapy, were included in prospective study group. The other 25 patients, chemotherapy alone same period, control parameters including blood volume(BV),...
Objective To evaluate the differences of toxicities, therapeutic efficacy and immune function between induction chemotherapy followed by sinusoidal chrono-modulated infusion flat intermittent cisplatin(DDP)with intensity-modulated radiotherapy (IMRT) in patients with locoregionally advanced nasopharyngeal carcinoma (NPC). Methods Seventy biopsy- diagnosed stages Ⅲ ⅣB NPC (according to 2010 UICC staging system) were treated two-cycle before chemoradiotherapy Guizhou Cancer Hospital....
Objective To investigate the delineation primary lesions of gross tumor volume (GTVnx) in locally advanced nasopharyngeal carcinoma (LANC). Methods During 2012–2013, 52 patients with LANC treated two-three cycles induction chemotherapy accepted CT simulation and MRI scans same treatment position. All images T1W1 sequence were collected transmitted to planning system. The target was delineated through images. Meanwhile, metastatic lymph nodes, CTV1, CTV2 organs at risk(OAR) alone. from...
6000 Background: Patients with N2-3 nasopharyngeal carcinoma have a high risk of failures, despite the current practice concurrent adjuvant cisplatin-5-fluorouracil (PF) regime. Adjuvant PF regimen may not be adequate for tumor control patients, emphasizing need more effective chemotherapy in carcinoma. Methods: We conducted this multicentre, open-label, phase 3, randomised, controlled trial four centers China. aged 18–65 years stage T1–4N2–3 were randomly assigned (1:1) to receive cisplatin...
Objective To investigate the delineation of gross tumor volume (GTV) in locally advanced nasopharyngeal carcinoma (LANC) according to imageological changes before and after induction chemotherapy (IC) order decrease high dose area protect normal tissue better.Methods Between Mar 2010 Jan 2011,11 patients with LANC were enrolled treated TPF regimen followed by intensity-modulated radiotherapy (IMRT) concurrent chemotherapy,target volumes delineated based on fused CT imaging IC following...
Objective To evaluate the therapeutic effects,acute and late side-effects of cisplatin plus 5-fluorouracil (PF) schemed chronomodulated chemotherapy combined with concurrent intensitymodulated radiotherapy(IMRT) for nasopharyngeal carcinoma.Methods A total 48 carcinoma patients treated IMRT were retrospectively studied.The radiation doses prescribed to gross target volume GTVnx nasopharyngeal,to positive neck lymphnodes GTVnd,to clinical CTV1,and CTV2 73.92-77.88,69.96,60.06-66.00...