CD4+ T cells mediate respiratory syncytial virus (RSV)-induced airway inflammation through secreting Th2 cytokines

• DOI: 10.3760/cma.j.issn.0254-5101.2017.10.005
• Publication Date: 2017-10-31
• Authors: Song Bai; Yulin Cui; Ruonan Chai; Yue Fan; Beixing Liu
• Keywords: Adoptive Cell Transfer; T helper cell; Proinflammatory cytokine

Objective To investigate the role of CD4+ T cells in airway inflammation induced by respiratory syncytial virus (RSV) infection.

Methods Animal models acute RSV infection were established. Lung tissues stained with hematoxylin and eosin (HE) to observe histopathological changes. Total number secreting Th1/Th2 cytokines (IFN-γ, IL-4, IL-5 IL-13) spleen detected flow cytometry. Adoptive transfer was performed identify RSV-induced inflammation.

Results RSV increased total splenic cells, particularly Th2-type cells. The absolute numbers IL-4/IL-5/IL-13-secreting significantly after infection. Furthermore, adoptive into BALB/c mice not only promoted infiltration mononuclear lung, but also enhanced secretion Th2 during infection.

Conclusion CD4+ are involved through cytokines.

Key words: Respiratory virus; CD4+ cell; Airway