Associations of the BRAF V600E mutation with sonographic features in patients with papillary thyroid carcinoma

• DOI: 10.3760/cma.j.issn.1004-4477.2016.09.012
• Publication Date: 2016-09-25
• Authors: Zhiyan Luo; Yurong Hong; Qing Wen; Caoxin Yan; Huifang Weng; Guoqiang Mo
• Keywords: V600E; Echogenicity

Objective To evaluate the association of BRAF V600E mutation with sonographic features in patients papillary thyroid carcinoma.

Methods A consecutive series 61 carcinoma(PTC) was evaluated by US and elastography before US-FNA, surgery.The PTCs were categorized into 2 groups according to results mutation, BRAF-positive BRAF-negative patients. The compared between patients.

Results The detected 82% (50 61). There no significant difference PTC on including nodular size, echogenicity, shape, margin, calcification pattern blood flow.However prevalence a score higher than 4 Hong et al 72% (36/50) group, significantly 36.4%(4/11) group(P=0.024). A correlated highly diagnosis (sensitivity 72.0%, specificity 63.6%, positive predictive value 90.0%, negative 33.3%, accuracy 70.5% OR 4.5).

Conclusions The associated classification, could predict occurrence cancer.

Key words: Ultrasonography; Thyroid neoplasms; Biopsy, fine-needle; BRAF