Posterior cingulated cortex functional connectivity in deficit schizophrenia: a resting state functional magnetic resonance imaging study

• DOI: 10.3760/cma.j.issn.1006-7884.2014.03.005
• Publication Date: 2014-06-05
• Authors: Xiaowei Tang; Deqin Geng; Weiwei Sha
• Keywords: Limbic lobe; Medial frontal gyrus; Middle frontal gyrus; Frontal lobe; Gyrus; Superior frontal gyrus

Objective To explore the discrepancies of network resting brain functional connectivity related to posterior cingulated cortex （PCC） between deficit schizophrenia patients and normal control.

Methods Thirty male schizophrenia, nondeficit 30 healthy controls were enrolled, age, education level sex matched three groups. Resting state fMRI was performed on all subjects. Correlation analysis PCC other voxels in with a voxel-wise manner changes groups compared.

Results There valid data 27 group,26 group, 25 persons control group. The scores SANS (26.7±2.4)and SDS (11.2±2.7) group higher than that (14.3±1.2，4.1±2.6;t=23.667，9.812，P<0.01）.（2）In groups, areas showing significant included left right middle frontal gyrus, superior inferior cerebellum, lobe temporal caudate nucleus, limbic lobe(parahippocampal gyrus), cuneate lobe, precuneus. （3）The weaker thalamus, parietal anterior cortex, while stronger precuneus lobule. （4）The non-deficit lobule precuneus, lobe.

Conclusions Deficit may exist specific mode, weakened regions connection be lobe,left gyrus so on. It suggests an independent disease subtype.

Key words: Schizophrenia; Magnetic resonance imaging; Brain function