A5101981271- Advanced biosensing and bioanalysis techniques
- Carbon and Quantum Dots Applications
- Nanocluster Synthesis and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Diabetic Foot Ulcer Assessment and Management
- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Mesenchymal stem cell research
- Ferroptosis and cancer prognosis
- Pluripotent Stem Cells Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Peripheral Neuropathies and Disorders
- EEG and Brain-Computer Interfaces
- Nuclear Receptors and Signaling
- Nerve injury and regeneration
- Bioinformatics and Genomic Networks
- Flavonoids in Medical Research
- Acupuncture Treatment Research Studies
- Autoimmune Neurological Disorders and Treatments
- Personality Disorders and Psychopathology
- ECG Monitoring and Analysis
- Protein Tyrosine Phosphatases
- Bone and Joint Diseases
Xuzhou Medical College
2016-2025
Affiliated Hospital of Xuzhou Medical College
2006-2023
Activities of catalase (CAT) and superoxide dismutase (SOD) ceria nanoparticles (CeO2 NPs) provide the possibility for their application in nervous system oxidative stress diseases including Alzheimer's disease (AD). The addition hot electrons produced by a plasma photothermal effect can expand photocatalytic activity CeO2 to near-infrared region (NIR), significantly improving its redox performance. Therefore, we coated both ends gold nanorods (Au NRs) with NPs, photocatalysis therapy NIR...
Obesity is a risk factor for neurodegenerative disease associated with cognitive dysfunction, including Alzheimer's disease. Low-grade inflammation common in obesity, but the mechanism between and impairment obesity unclear. Accumulative evidence shows that quinolinic acid (QA), neuroinflammatory neurotoxin, involved pathogenesis of processes. We investigated role QA obesity-induced beneficial effect butyrate counteracting impairments cognition, neural morphology, signaling. show human there...
Amyloid β-peptide oligomer (AβO) is widely acknowledged as the promising biomarker for diagnosis of Alzheimer's disease (AD). In this work, we designed a three-dimensional (3D) DNA walker nanoprobe AβO detection and real-time imaging in living cells vivo. The presence triggered DNAzyme walking strand to cleave fluorophore (TAMRA)-labeled substrate modified on gold nanoparticle (AuNP) surface release TAMRA-labeled fragment, resulting recovery fluorescent signal. entire process was autonomous...
INTRODUCTION Sleep disturbance is one of the most common nonmotor symptoms in Parkinson's disease (PD). affects 40–98% PD patients world.[123] In China, prevalence with sleep ranges from 47.66% to 89.10%.[456789] usually has adverse impact on quality life patients. A possible pathogenesis include thalamocortical pathway degeneration and changes neurotransmitter systems.[3] The etiology multifactorial, involving areas regulating sleep, structure affected by drugs, induced drug, fragmentation...
Several studies have indicated an association between major depressive disorder (MDD) and allergic diseases (ADs), but the exact causal relationship remains inconclusive. Thus, this study aimed to explore MDD ADs employing bidirectional two-sample Mendelian randomization (MR). The summary statistics for were sourced from Psychiatric Genomics Consortium. Single nucleotide polymorphisms (SNPs) associated with asthma (AAS), rhinitis (AR), atopic dermatitis, extracted FinnGen inverse variance...
NF-κB signaling pathway shows significant influence on wear particle-induced osteolysis, and this study aims to explore the underlying mechanism role of let-7f-5p in process. A mouse calvarial osteolysis model was constructed with PMMA particles, bone marrow-derived macrophages (BMMs) were isolated from area. The expression miRNA protein determined by qRT-PCR western blot, respectively. level cytokines evaluated ELISA. Recombinant plasmids transfected into cells for endogenous related genes....
The proliferation of physiological signals acquisition and monitoring system, has led to an explosion in data. Additionally, RFID systems, blockchain technologies, the fog computing mechanisms have significantly increased availability signal information through big data research. driver for development hybrid systems is continuing effort making health-care services more efficient sustainable. Implantable medical devices (IMD) are therapeutic that surgically implanted into patients' body...
This aim of this study was to delineate current clinical scenarios painful diabetic peripheral neuropathy (PDN) and associated anxiety depression among patients in Mainland China, report therapy practices. A total 1547 participants were enrolled the between 14 June 2018 11 November 2019. Recruitment conducted using a multilevel sampling method. Participants' demographics, medical histories, glucose parameters, Douleur Neuropathique 4 Questionnaire (DN4) scores, visual analogue scale (VAS)...
A novel strategy for telomerase imaging was developed based on telomerase-triggering primer extension to desorb fluorophore labeled DNA from graphene oxide.
Nitrogen-doped carbon nanocage (N-CNC) modulated turn-on fluorescent probes were developed for selective detection of ATP and applied to the imaging in living cells.
Objective To investigate anxiety of clinicians in tertiary hospitals, and discuss the factors that influence clinicians' order to provide reference for further effective intervention measures. Methods 427 from various departments hospitals selected by cluster sampling method were self-rating scale (SAS). Statistical software SPSS 17.0 was used analyze data multivariate logistic regression analysis its relevant influencing factors. Results 38.2% had symptoms (55.0% mild anxiety,...
Abstract Objective. Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental in children. While numerous intelligent methods are applied for its subjective diagnosis, they seldom consider the consistency problem of ADHD biomarkers. In practice, these data-driven approaches lead to varying learned features classification across diverse datasets. This phenomenon significantly undermines reliability identified biomarkers and hampers interpretability methods. Approach....
Objective To explore the discrepancies of network resting brain functional connectivity related to posterior cingulated cortex （PCC） between deficit schizophrenia patients and normal control. Methods Thirty male schizophrenia, nondeficit 30 healthy controls were enrolled, age, education level sex matched three groups. Resting state fMRI was performed on all subjects. Correlation analysis PCC other voxels in with a voxel-wise manner changes groups compared. Results There valid...