A5100648440- Esophageal Cancer Research and Treatment
- Thyroid Disorders and Treatments
- Corneal surgery and disorders
- RNA modifications and cancer
- Pregnancy and preeclampsia studies
- Cancer-related gene regulation
- Neurological Disease Mechanisms and Treatments
- Lymphoma Diagnosis and Treatment
- Esophageal and GI Pathology
- Traditional Chinese Medicine Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Inflammatory mediators and NSAID effects
- Glaucoma and retinal disorders
- Thyroid Cancer Diagnosis and Treatment
- Diabetic Foot Ulcer Assessment and Management
- Gastroesophageal reflux and treatments
- Genetic and phenotypic traits in livestock
- Neurosurgical Procedures and Complications
- Ophthalmology and Visual Impairment Studies
- Corneal Surgery and Treatments
- Gastric Cancer Management and Outcomes
- Foreign Body Medical Cases
- Acupuncture Treatment Research Studies
- Neuroendocrine Tumor Research Advances
- Agriculture, Soil, Plant Science
University of Science and Technology Beijing
2024
Hubei University of Arts and Science
2017-2024
Xiangyang Central Hospital
2016-2024
Pingdingshan University
2024
Guiyang Medical University
2023
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2023
Shanxi University
2023
Wuhan University
2023
Renmin Hospital of Wuhan University
2023
Shanghai Mental Health Center
2015-2022
Guidelines of the American Thyroid Association (ATA) proposed that upper limit TSH reference range should be 2.5 mIU/L in first trimester, but reported ranges China are significantly higher.Our objective was to establish a rational serum for diagnosis subclinical hypothyroidism trimester pregnant women China.We screened 4800 and 2000 who planned become evaluated 535 follow-up visits during second third trimester.Median concentrations decreased from seventh week gestation. The median 4 6...
The WHO Technical Consultation recommends urinary iodine concentrations (UIC) from 250 to 499 μg/L as more-than-adequate intake and UIC ≥ 500 excessive for pregnant lactating women, but scientific evidence this is weak.We investigated optimal safe ranges of during early pregnancy in an iodine-sufficient region China.Seven thousand one hundred ninety women at 4-8 weeks gestation were their UIC, serum thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroid-peroxidase antibody (TPOAb),...
Isolated hypothyroxinemia during early pregnancy may irreversibly damage the neurodevelopment of offspring. However, causes are not well clarified.To explore association iron deficiency (ID) with hypothyroid function women in and nonpregnant women.A total 7953 pregnant ≤ 12 weeks gestation 2000 childbearing-aged were recruited. A subpopulation including 3340 1052 sufficient iodine intake negative thyroid peroxidase antibody studied. Mild severe cases defined as free T4 levels below 10th...
Abstract Angioimmunoblastic T‐cell lymphoma (AITL) is a neoplastic proliferation of T follicular helper cells with clinical and histological presentations suggesting role antigenic drive in its development. Genetically, it characterized by stepwise acquisition somatic mutations, early mutations involving epigenetic regulators ( TET2 , DNMT3A ) occurring haematopoietic stem cells, subsequent changes signaling molecules RHOA VAV1 PLCG1, CD28 critical for biology. To search evidence potential...
Background . Maternal thyroid dysfunction in early pregnancy may increase the risk of adverse complications and neurocognitive deficiencies developing fetus. Currently, some researchers demonstrated that body mass index (BMI) is associated with function nonpregnant population. Hence, American Thyroid Association recommended screening obese pregnant women; however, evidence for this weak. For purpose, our study investigated relationship between high BMI functions during Liaoning province, an...
Background: The Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) are the most commonly used tools for cognitive impairment screening. present study aimed to investigate ability of MOCA MMSE differentiate between cognitively normal elderly individuals, MCI patients dementia at different ages education levels establish optimal cutoff scores MoCA in Chinese elderly. Methods: A total 2,954 including 1,746 controls, 599 249 patients, were consecutively recruited...
Abstract NKX2 homeobox family proteins have a role in cancer development. Here we show that - 3 is overexpressed tumour cells from subset of patients with marginal-zone lymphomas, but not other B-cell malignancies. While Nkx2-3 -deficient mice exhibit the absence B cells, transgenic expression NKX2-3 expansion leads to development tumours, faithfully recapitulating principal clinical and biological features human lymphomas. induces receptor signalling by phosphorylating Lyn/Syk kinases,...
// Ming Wang 1, * , Shaowei Zhang 2, Shih-Sung Chuang 3 Margaret Ashton-Key 4 Eguzkine Ochoa 1 Niccolo Bolli 5, 6, 7 George Vassiliou 5 Zifen Gao 2 Ming-Qing Du Division of Molecular Histopathology, Department Pathology, University Cambridge, UK Health Science Centre, Peking University, Beijing, China Chi-Mei Medical Center, Tainan, Taiwan Cellular Southampton Hospitals National Service Foundation Trust, Southampton, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, 6 Oncology and...
Background: Late-onset Alzheimer's disease (LOAD) and early-onset (EOAD) are different subtypes of AD. This study aimed to build validate radiomics models the hippocampus for EOAD young controls (YCs), LOAD old (OCs), as well LOAD. Methods: Thirty-six patients, 36 YCs, OCs from Disease Neuroimaging Initiative (ADNI) database were enrolled allocated training test sets EOAD-YC groups, LOAD-OC EOAD-LOAD groups. Independent external validation including 15 Shanghai Mental Health Center...
Purpose This study aimed to identify risk factors associated with small-incision lenticule extraction (SMILE) surgery and develop a prediction model aid in determining patient suitability for SMILE. Methods retrospective included myopia patients from four medical centers China, enrolled between January 2021 December 2023. The data were randomly divided into training test cohorts at an 8:2 ratio. A random forest (RF) was developed optimized using three-fold cross-validation, feature...
Background: A self-sequential longitudinal reference interval may be expected to minimize the inter-individual variation of thyroid function. Comparison between (SLRI) and cross-sectional (CSRI) in pregnancy has not been well investigated. The objectives this study were establish a stringent SLRI function pregnant women compare it with conventional CSRI. Methods: Three cohorts enrolled: group 1, for an (n = 99); 2, CSRI 1318); 3, non-pregnant control (NC) as 301) according criteria National...
Background: Esophageal cancer (EC) is a primary malignant tumor originating from the esophageal of epithelium. Surgical resection potential treatment for EC, but this only appropriate patients who have locally resectable lesions suitable surgery. However, most with EC are at late stage when diagnosed. Therefore, there an urgent need to further explore pathogenesis enable early diagnosis and treatment. Methods: Our study downloaded 2 expression spectrum datasets (GSE92396 GSE100942) in Gene...
Background Whether keratoconus (KC) is an inflammatory disease currently debated. Hence, we aimed to investigate the immune-related features of KC based on single-cell RNA sequencing (scRNA-seq) and bulk (bulk RNA-seq) data. Methods scRNA-seq data were obtained from Genome Sequence Archive (GSA), RNA-seq Gene Expression Omnibus (GEO), immune-associated genes(IAGs) ImmPort database. Cell clusters annotated, different cell then selected. The IAG score each was calculated using AUCell package....
Our previous study showed that aspirin induced apoptosis of esophageal cancer cells in vitro by inhibiting the pathway NF-kappaB downstream regulation cyclooxygenase-2. The purpose this was to determine if similar changes occurred vivo tumors patients with SCC esophagus who were given a preferential COX-2 inhibitor, meloxicam. Fifty-three had an esophagectomy for allocated randomly either Treatment group (n = 25) or control 28). Patients 7.5 mg/day meloxicam, between 10 and 14 days before...
Lung cancer is a leading global cause of cancer-related death, and lung adenocarcinoma (LUAD) accounts for ~ 50% cancer. Here, we screened novel specific biomarkers LUAD by searching differentially expressed mRNAs (DEmRNAs) microRNAs (DEmiRNAs) in patient expression data within The Cancer Genome Atlas (TCGA). identified optimal diagnostic miRNA were used to establish classification models (including support vector machine, decision tree, random forest) distinguish between adjacent tissues....
The human protein tyrosine phosphatase, non‑receptor type 6 (PTPN6) gene is located on chromosome 12p13 and encodes an Mr 68,000 protein‑tyrosine phosphatase. PTPN6 has been considered as a candidate tumor suppressor in hematological solid malignancies, promoter methylation may be epigenetic modification silencing its expression. However, the detailed role of status pathogenesis esophageal squamous cell carcinoma (ESCC) not fully elucidated. aim present study was to investigate expression...
Background: Aspirin has potential in the prevention or treatment of oesophageal cancer, seventh most common cancer world, but its mechanism action is still not certain. Methods: The squamous cell carcinoma line TE‐13 was cultured with aspirin at different concentrations for times. Proliferation and apoptosis were measured by MTT reduction flow cytometry. Expression COX‐2 mRNA RT‐PCR protein levels Western blot analysis. Nuclear NF‐kappaB cytoplasmic IkappaB determined electrophoretic...
Infectious endocarditis (IE) is a rare disease with high mortality rate. Recently, red cell distribution width (RDW) has drawn special attention for predicting cardiovascular disease. This study aims to explore the relationship between RDW value and postoperative death of IE patients.
This aim of this study was to delineate current clinical scenarios painful diabetic peripheral neuropathy (PDN) and associated anxiety depression among patients in Mainland China, report therapy practices. A total 1547 participants were enrolled the between 14 June 2018 11 November 2019. Recruitment conducted using a multilevel sampling method. Participants' demographics, medical histories, glucose parameters, Douleur Neuropathique 4 Questionnaire (DN4) scores, visual analogue scale (VAS)...
The root system in plants absorbs water and minerals. However, the relationship among size, yield, use efficiency (WUE) is controversial. Two pot experiments were conducted to explore these relationships by using two maize varieties with contrasting sizes reducing root-shoot ratio (R/S) through pruning eliminate genotypic effects. Maize grown an open rainout shelter under both water-sufficient deficient conditions. Yield-related parameters, hydraulic conductivity (Lpr), WUE determined....
Cholecystokinin (CCK) and gastrin exert their influences via CCK receptors. This research was conducted to look at the responses of sling clasp fibers forming human lower esophageal sphincter (LES) gastrin, role receptors in responses.Muscle strips from LES were obtained patients undergoing subtotal esophagectomy. Isometric tension CCK-8 gastrin-17 studied, maximum effect (E(max)) for each agonist derived. CCK-A receptor antagonist, CR1409 CCK-B CR2945 applied pK(B) values calculated.Sling...
Objective. To evaluate the efficacy and safety of sustained-release (SR) oxycodone tablets in treatment moderate to severe painful diabetic peripheral neuropathy (DPN). Design. This was a multicenter, randomized, open-labeled study. Setting. study completed 12 hospitals China. Patients. A total 80 Chinese patients undergoing DPN. Interventions. An initial dose 10 mg is recommended be taken orally every hours. Dose titration done appropriately according pain intensity adverse reactions....