A5087514570- DNA Repair Mechanisms
- Mobile Ad Hoc Networks
- DNA and Nucleic Acid Chemistry
- Wireless Networks and Protocols
- Synthesis and biological activity
- Natural product bioactivities and synthesis
- Opportunistic and Delay-Tolerant Networks
- Quinazolinone synthesis and applications
- Cancer therapeutics and mechanisms
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Bioactive Compounds and Antitumor Agents
- Carcinogens and Genotoxicity Assessment
- Ferroptosis and cancer prognosis
- Pharmacological Effects of Natural Compounds
- Synthesis and Biological Evaluation
- Matrix Theory and Algorithms
- PI3K/AKT/mTOR signaling in cancer
- Plant Genetic and Mutation Studies
- Circular RNAs in diseases
- Fungal Plant Pathogen Control
- Telomeres, Telomerase, and Senescence
- Phytochemical compounds biological activities
- CRISPR and Genetic Engineering
Guiyang Medical University
2016-2025
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2016-2025
Shanghai Pulmonary Hospital
2019-2024
Tongji University
2006-2024
JPMorgan Chase & Co (United States)
2024
Pulmonary Hypertension Association
2022
Weatherford College
2022
Guizhou University
2011-2021
Affiliated Hospital of Guizhou Medical University
2020
Sericultural Research Institute
2020
The importance of miRNAs in the progression prostate cancer (PCa) has further been supported by finding that have identified as potential oncogenes or tumor suppressors PCa. Indeed, eukaryotes, found to regulate and control gene expression degrading mRNA at post-transcriptional level. In this study, we investigated miR-34 family members, miR-34b miR-34c, different PCa cell lines, discussed molecular mechanism invasion migration cells vitro. difference analyses transcriptome between DU145 PC3...
Although androgen deprivation therapy may initially be effective in prostate cancer, the disease can gradually progress to castration-resistant at which point chemotherapy becomes major clinical strategy.In this study, we demonstrated anti-cancer potential of a novel 3',5'-diprenylated chalcone (C10), selectively inhibited proliferation PC3 cells vitro and vivo.C10 treatment elevated proportion sub-G1 phase induced programmed cell death.Interestingly, C10 elicited concurrent...
Abstract Lactic acidosis is a feature of solid tumors and plays fundamental role(s) rendering cancer cells to adapt diverse metabolic stresses, but the mechanism underlying its roles in redox homeostasis remains elusive. Here we show that G6PD phosphorylated at tyrosine 249/322 by SRC through formation GSTP1-G6PD-SRC complex. acid attenuates this phosphorylation non-covalently binding with GSTP1. Furthermore, lactic increases activity facilitates PPP (NADPH production) sensor GSTP1, thereby...
The oleanane-type triterpene 18β-glycyrrhetinic acid (1) was modified chemically through the introduction of a trihydroxylated A ring and an ester moiety at C-20 to enhance its antibacterial activity. Compounds 22, 23, 25, 28, 29, 31, 32 showed more potent inhibitory activity against Streptomyces scabies than positive control, streptomycin. Additionally, most compound, Bacillus subtilis, Staphylococcus aureus, methicillin-resistant aureus greater that controls. mode action active derivatives...
Endometrial cancer had a relatively high prevalence of MMR deficiency. MMR-D/MSI-H endometrial patients are suggested to be potential beneficiaries PD-1/PD-L1 inhibitor therapy. Here, we explored the prognostic value MSI subtype in and its correlation with immune environment. Based on expression clinical data 78 POLE, 123 299 Other EC samples from TCGA-UCEC project, found that tumors were identified more often early stage, lower age, better patient survival, enriched CD8+ T cells, regulatory...
BACKGROUND Diabetic retinopathy (DR) is one of the major eye diseases contributing to blindness worldwide. Endoplasmic reticulum (ER) stress in retinal cells a key factor leading inflammation and vascular leakage DR, but its mechanism still unclear. AIM To investigate potential LEF1 related RNAs DR. METHODS ARPE-19 were exposed high levels glucose for 24 hours simulate diabetic environment. Intraperitoneally injected streptozotocin was used induce rat model The expression genes proteins...
It is well known that, for a series of submerged artificial bars uniformly distributed in the coastal region parallel to coastline, if wavelength incident wave train twice that bar distance, Bragg resonant reflection occurs. In this paper, three closed-form analytical solutions linear long-wave with triangular shape, rectified cosinoidal and idealized trapezoidal shape are presented. These show magnitude peak still depends on parameters, which number, dimensionless height, width. Based...
// Tangjingjun Liu 1, 7, * , Yao Gang Zhang 1 Ye Wang 2 Bin Deng Jialei Song 8 Xiaogang Li Fei Han Xiao 7 Jue Yang Lei Xia 3 You-Jun 4 Maksym Plachynta Mu Chen Yan Shuzhen Heng Luo Eldad Zacksenhaus 5, 6 Xiaojiang Hao 3, Yaacov Ben-David Department of Biology and Chemistry, The Key Laboratory Chemistry for Natural Products Guizhou Province Chinese Academy Sciences, Guizhou, China College Ecology, Lishui University, Zhejiang, School Pharmaceutical Anatomy, Norman Bethune Medicine, Jilin...
The friend leukemia integration 1 (Fli-1) gene is involved in the expression control of key genes multiple pathogenic/physiological processes, including cell growth, differentiation, and apoptosis; this implies that Fli-1 a strong candidate for drug development. In our previous study, 3′,5′-diprenylated chalcone, (E)-1-(2-hydroxy-4-methoxy-3,5-diprenyl) phenyl-3-(3-pyridinyl)-propene-1-one (C10), was identified as novel anti-prostate cancer (PCa) agent. Here, we investigated molecular...
Cervical cancer is the leading cause of death among gynecological malignant tumors, especially due to poor prognosis patients with advanced tumors recurrence, metastasis, and chemotherapy resistance. Therefore, exploring new antineoplastic drugs high efficacy low toxicity may bring expectations in cervical cancer. Natural products their derivatives exert an antitumor activity. this work, combined network pharmacology analysis experimental validation, we investigated anti-cervical activity...
Androgen receptor (AR) is one of the key targets for treatment Castration-resistant prostate cancer (CRPC). Current endocrine therapy can greatly improve CRPC patients. However, with change pathogenic mechanism, acquired resistance often leads to failure treatment. Studies have shown that tanshinone IIA (TS-IIA) and its derivatives significant antitumor activity, certain AR targeting effects, but mechanism unknown. In this study, TS-IIA analog TB3 was found significantly inhibit growth in...
Prostate cancer (PCa), an epithelial malignant tumor, is the second common cause of death among males in western countries. Thus, development new strategies urgently needed. Tanshinones isolated from Salvia miltiorrhiza and its synthetic analogs show various biological activities including anticancer effects. Among them, tanshinone analog 2-((Glycine methyl ester)methyl)-naphtho (TC7) most effective, with better selectivity lower toxicity. Therefore, this work, effect TC7 against PCa was...
Sustained drug release has attracted increasing interest in targeted therapy. However, existing methods of therapy suffer action time, large fluctuations the effective concentration drug, and risk side effects. Here, a biodegradable composite polybutylene adipate co-terephthalate/polyvinylpyrrolidone (PBAT/PVP) consisting electrospun hollow microspheres as sustained-released carriers is presented. The as-prepared PBAT/PVP composites show faster degradation rate (Erlotinib) than that PBAT....