Effects of hyperbaric oxygen preconditioning on human energy metabolism under high altitude hypoxia

• DOI: 10.3760/cma.j.issn.1009-6906.2015.02.003
• Publication Date: 2015-04-28
• Authors: Lu Shi; Yangyang Li; Yanmeng Zhang; Xi Jiang; Enzhi Feng; Yongcun Wang; Duojie Gengsong; Shenggui Dai; Haifeng Xu
• Keywords: Hypoxia; Stairs

Objective To investigate changes in human energy metabolism both before and after physical load under high altitude hypoxia effects of hyperbaric oxygen preconditioning (HBOP).

Methods Six healthy male soldiers who used to live the plain region, joined army, moved plateau region 6 12 months ago were enrolled for our study. The levels glucose(Glu), blood lactate(BLA), lactate dehydrogenase(LDH)and Na+-K+-ATPase detected HBOP, 5 7 days HBOP as well. mode exercise was 5-minute stair-climbing, at a rate 25 stairs minute, with height stair being 30 cm. A pacemaker control climbing up record time, intensity equivalent 650 kg·m/min.

Results Following no signficant could be found Glu, BLA, LDH rest, when compared those (P>0.05). However, load, Glu [(5.31±0.27) and(4.61±0.26)mmol/L] significantly increased, [(4.23±0.25) mmol/L], statistical signficance(P<0.05 or P<0.01). 5-day [(1.00±0.03)mmol/L, (216.33±16.87)U and(5.65±0.51)μmolPi/mgpr.h], 7-day [(0.92±0.04)mmol/L, (192.38±15.06)U and(5.38±0.38)μmolPi/mgpr.h], which obviously lower than [(1.08±0.07)mmol/L, (244.24±21.82)U and(6.49±0.46)μmolPi/mgpr.h], also P<0.01)

Conclusions Short-term improve military personnel accelerate glycogenolysis elevate level, lessen accumulation BLA decrease activity enable muscles make better use oxygen, thus reducing fatigue improving working efficiency.

Key words: Hyperbaric oxygen; Physical load; Glucose; Blood lactate; Lactate dehydrogenase; Na+-K+-ATPase