A5030255850- Chronic Lymphocytic Leukemia Research
- High Altitude and Hypoxia
- Advanced Breast Cancer Therapies
- Molecular Sensors and Ion Detection
- Heart Rate Variability and Autonomic Control
- Fungal and yeast genetics research
- Microbial Metabolic Engineering and Bioproduction
- Cancer Cells and Metastasis
- Gene expression and cancer classification
- PI3K/AKT/mTOR signaling in cancer
- Diabetic Foot Ulcer Assessment and Management
- 3D Printing in Biomedical Research
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Cancer Genomics and Diagnostics
- Biofuel production and bioconversion
- Additive Manufacturing and 3D Printing Technologies
- Lymphoma Diagnosis and Treatment
- Bioinformatics and Genomic Networks
Oslo University Hospital
2021-2025
University of Oslo
2021-2023
Peking Union Medical College Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Guizhou Normal University
2016
Abstract Purpose: The management of chronic lymphocytic leukemia (CLL) has significantly improved with targeted therapies. However, many patients experience a suboptimal response. To optimally select the best therapy, predictive biomarkers are necessary. Here, we used PI3K inhibitor umbralisib as model to (i) understand how treatment affects cell signaling and immunophenotypes in responders non-responders; (ii) identify molecular features that predict individual responses; (iii) suggest...
<div>AbstractPurpose:<p>The management of chronic lymphocytic leukemia (CLL) has significantly improved with targeted therapies. However, many patients experience a suboptimal response. To optimally select the best therapy, predictive biomarkers are necessary. In this study, we used phosphoinositide 3-kinase (PI3K) inhibitor umbralisib as model to (i) understand impact treatment on cell signaling and immunophenotypes in responders nonresponders, (ii) identify molecular features...
<p>Supplementary Figures 1-10</p>
Ductal carcinoma in situ (DCIS) is a preinvasive form of breast cancer with highly variable potential becoming invasive and affecting mortality the patients. Due to lack accurate markers disease progression, many women detected DCIS are currently overtreated. To distinguish those cases who likely require therapy from should be left untreated, there need for robust predictive biomarkers extracted molecular or genetic profiles. We developed supervised machine learning approach that implements...
PI3K inhibitors (PI3Ki) are approved for relapsed chronic lymphocytic leukemia (CLL). Although patients may show an initial response to these therapies, development of treatment intolerance or resistance remain clinical challenges. To overcome these, prediction individual responses based on actionable biomarkers is needed. Here, we characterized the activity and cellular effects 10 PI3Ki investigated whether functional analyses can identify vulnerabilities in PI3Ki-refractory/intolerant CLL...
Objective To investigate changes in human energy metabolism both before and after physical load under high altitude hypoxia effects of hyperbaric oxygen preconditioning (HBOP). Methods Six healthy male soldiers who used to live the plain region, joined army, moved plateau region 6 12 months ago were enrolled for our study. The levels glucose(Glu), blood lactate(BLA), lactate dehydrogenase(LDH)and Na+-K+-ATPase detected HBOP, 5 7 days HBOP as well. mode exercise was 5-minute...
The central carbon metabolic system is the upstream energy source for microbial fermentation. In addition, it a master switch increasing production of metabolites and an important part network. Investigation into relationship between genes, environmental factors, networks main focus systems biology, which significantly impacts research in biochemistry, engineering, synthetic biology. To this end, flux under variety growth conditions or using strains with various genetic modifications was...
Objective To investigate changes in hemodynamics both before and after physical exercise the protective effects of hyperbaric oxygen preconditioning (HBOP) on soldiers, so as to find out new measures for enhancement human performance at high plateau regions. Methods Six healthy male soldiers who used live plain region, joined army, moved an altitude 3 800 m 6 24 months ago were voluntarily enrolled our study. Such hemodynamic parameters stroke volume (SV), left ventricular ejection...
Objective To investigate the state of oxidation/anti-oxidation before and after load exercises in military personnel who moved from plain to plateau, intervention effects hyperbaric oxygen (HBO) preconditioning. Methods Six healthy male soldiers used live region, joined army, plateau region 6 12 months ago were enrolled for our study. Before HBO preconditioning 5-day 7-day preconditioning, changes levels serum 8-iso PGF2α, malondialdehyde (MDA), superoxide dismutase (SOD) GSH-Px...
<div>AbstractPurpose:<p>PI3K inhibitors (PI3Ki) are approved for relapsed chronic lymphocytic leukemia (CLL). Although patients may show an initial response to these therapies, development of treatment intolerance or resistance remain clinical challenges. To overcome these, prediction individual responses based on actionable biomarkers is needed. Here, we characterized the activity and cellular effects 10 PI3Ki investigated whether functional analyses can identify vulnerabilities...
<div>AbstractPurpose:<p>PI3K inhibitors (PI3Ki) are approved for relapsed chronic lymphocytic leukemia (CLL). Although patients may show an initial response to these therapies, development of treatment intolerance or resistance remain clinical challenges. To overcome these, prediction individual responses based on actionable biomarkers is needed. Here, we characterized the activity and cellular effects 10 PI3Ki investigated whether functional analyses can identify vulnerabilities...
Supplementary Figure from Functional Testing to Characterize and Stratify PI3K Inhibitor Responses in Chronic Lymphocytic Leukemia
Supplementary Figure from Functional Testing to Characterize and Stratify PI3K Inhibitor Responses in Chronic Lymphocytic Leukemia
Supplementary Figure from Functional Testing to Characterize and Stratify PI3K Inhibitor Responses in Chronic Lymphocytic Leukemia
Supplementary Figure from Functional Testing to Characterize and Stratify PI3K Inhibitor Responses in Chronic Lymphocytic Leukemia