Computational model of sphingolipids metabolism: a case study of Alzheimer's disease

• DOI: 10.48550/arxiv.1411.2441
• Publication Date: 2014-01-01
• Authors: Agata Charzyńska; Weronika Wronowska; Karol Nienałtowski; Anna Gambin
• Keywords: Sphingolipid

Background: Sphingolipids - as suggested by the prefix in their name are mysterious molecules, which play surprisingly various roles opposable cellular processes, like autophagy, apoptosis, proliferation and differentiation. Recently they have been also recognized important messengers signalling pathways. More importantly, sphingolipid metabolism disorders were observed pathological conditions such cancer neurodegeneration. Results: Existing formal models of sphingolipids concentrates mostly on de novo ceramide synthesis or restrict focus to biochemical transformations a particular subspecies. We propose first comprehensive computational model human tissue. In contrast previous approaches we explicitly compartmentalization what allows emphasizing differences among individual organelles. Conclusions: Presented here was validated means recently proposed analysis technics allowing for detection most sensitive experimentally non-identifiable parameters determination main sources variance. Moreover, demonstrate utility study molecular processes underlying Alzheimer's disease.