Additional file 1: of Untargeted Mass Spectrometry Lipidomics identifies correlation between serum sphingomyelins and plasma cholesterol

• DOI: 10.6084/m9.figshare.7665887.v1
• Publication Date: 2019-02-02
• Authors: Pierre Zalloua; Hanane Kadar; Essa Hariri; Layal Abi Farraj; François Brial; Lyamine Hedjazi; Aurélie Le Lay; Alexandre Colleu; Justine Dubus; David Touboul; Fumihiko Matsuda; Mark Lathrop; Jeremy K. Nicholson; Marc‐Emmanuel Dumas; Dominique Gauguier
• Keywords: Metabolome

Figure S1. Representative total ion current (TIC) chromatogram profiles in positive (A) & negative (B) modes. Data were obtained following untargeted liquid chromatography mass spectrometry (LC-MS) analysis with a CSH C18 columnof quality control samples representing pool of plasma samples. Retention times (X-axis) are plotted against relative intensity the spectral peaks (Y-axis). Approximate positions families lipid compounds shown: CE Ceramides, DG Diacyglycerol, FA Fatty Acids, PC Phosphatidylcholines, PE Phosphatidylethanolamines, PG Phosphatidylglycerolipids, PI phosphatidylinositols, PS phosphatidylserines, SM sphingomyelins, TG Triacylglycerol. S2. 3-D Principal component data cohort. Metabolome from cohort processed column analyzed after filtering and normalization for mode (B). S3. Metabolome-wide association between metabolic features LDL (A, B) (C, D) cholesterol. Metabolomic by column.Spectral referenced their to charge ratio statistical significance cholesterol Association results shown C) (B, ionization (PPTX 579 kb)