A5021892598- Corneal surgery and disorders
- Metabolomics and Mass Spectrometry Studies
- Hormonal Regulation and Hypertension
- Corneal Surgery and Treatments
- dental development and anomalies
- Mass Spectrometry Techniques and Applications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Intraocular Surgery and Lenses
- Adrenal Hormones and Disorders
- Ocular Disorders and Treatments
- Gestational Diabetes Research and Management
- Glaucoma and retinal disorders
- Adrenal and Paraganglionic Tumors
- Ophthalmology and Visual Impairment Studies
- Biochemical and Molecular Research
- Stress Responses and Cortisol
- Oral microbiology and periodontitis research
- Genetic Syndromes and Imprinting
- Bone and Dental Protein Studies
- Alkaline Phosphatase Research Studies
- interferon and immune responses
- Bariatric Surgery and Outcomes
- Hormonal and reproductive studies
- Lipid Membrane Structure and Behavior
- Ocular Surface and Contact Lens
University of Leeds
2013-2024
University of California, Los Angeles
2024
Lebanese American University
2019
A mutation miR-184(+57C>T) in the seed region of miR-184 (encoded by MIR184 [MIM*613146]) results familial severe keratoconus combined with early-onset anterior polar cataract and endothelial dystrophy, iris hypoplasia, congenital cataract, stromal thinning (EDICT) syndrome (MIM#614303). In order to investigate phenotypic spectrum resulting from mutation, was sequenced a cohort mixed ethnicity Chinese axial myopia cohort.Sequencing performed 780 unrelated patients 96 Han southern subjects...
We identified a family in which pitted hypomineralized amelogenesis imperfecta (AI) with premature enamel failure segregated an autosomal recessive fashion. Whole-exome sequencing revealed missense mutation (c.586C>A, p.P196T) the I-domain of integrin-β6 (ITGB6), is consistently predicted to be pathogenic by all available programmes and only variant that segregates disease phenotype. Furthermore, recent study mice lacking functional allele Itgb6 display hypomaturation AI Phenotypic...
Lipoproteins are major players in the development and progression of atherosclerotic plaques leading to coronary stenosis myocardial infarction. Epidemiological, genetic experimental observations have implicated association sphingolipids intermediates sphingolipid synthesis atherosclerosis. We aimed investigate relationships between quantitative changes serum sphingolipids, regulation metabolism lipoproteins (LDL, HDL), endophenotypes artery disease (CAD). carried out untargeted liquid...
The Middle East has the fastest rising rate of Type 2 Diabetes Mellitus (T2DM) worldwide, with Lebanon having 15.8% its population affected. This study aims at studying Polycystic Ovarian Syndrome (PCOS), Gestational (GDM), and macrosomia as risk factors T2DM in Lebanon. Such epidemiological statistical never been conducted before region would be useful for clinical diagnosis. Our cohort is comprised 1453 Lebanese individuals, 897 controls 556 patients. We tested correlation between...
ABSTRACT Cortisol excess drives multiple adverse effects including hypertension, dyslipidemia, and delayed wound healing. Activation of cortisol by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) has shown promise as a therapeutic target for these comorbidities but clinical progress been hampered variable 11β-HSD1 inhibitor efficacy. Here, transcriptomic profiling genes in primary skin fibroblasts well biopsies from 2 diabetes individuals treated with selective AZD4017 provide...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Figure S1. Representative total ion current (TIC) chromatogram profiles in positive (A) & negative (B) modes. Data were obtained following untargeted liquid chromatography mass spectrometry (LC-MS) analysis with a CSH C18 columnof quality control samples representing pool of plasma samples. Retention times (X-axis) are plotted against relative intensity the spectral peaks (Y-axis). Approximate positions families lipid compounds shown: CE Ceramides, DG Diacyglycerol, FA Fatty Acids, PC...