A5005076925- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Genetic Associations and Epidemiology
- dental development and anomalies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- RNA modifications and cancer
- Soft tissue tumors and treatment
- Tracheal and airway disorders
- Mesenchymal stem cell research
- Congenital Anomalies and Fetal Surgery
- Head and Neck Surgical Oncology
- Folate and B Vitamins Research
- Atherosclerosis and Cardiovascular Diseases
- Forensic and Genetic Research
- Periodontal Regeneration and Treatments
- Gestational Diabetes Research and Management
- Blood Pressure and Hypertension Studies
- Esophageal and GI Pathology
- Tissue Engineering and Regenerative Medicine
- Forensic Anthropology and Bioarchaeology Studies
- Nuclear Receptors and Signaling
- Lipid metabolism and disorders
- Chronic Kidney Disease and Diabetes
- Bariatric Surgery and Outcomes
Lebanese American University
2011-2024
de Duve Institute
2002-2011
UCLouvain
2009-2011
Laboratory of Molecular Genetics
2010
Princess Anne Hospital
2004
Genome wide association studies (GWAS) and their replications that have associated DNA variants with myocardial infarction (MI) and/or coronary artery disease (CAD) are predominantly based on populations of European or Eastern Asian descent. Replication the most significantly polymorphisms in multiple distinctive genetic backgrounds lifestyles is crucial to understanding pathophysiology a multifactorial like CAD. We used our Lebanese cohort perform replication study nine previously...
The Middle East was a funnel of human expansion out Africa, staging area for the Neolithic Agricultural Revolution, and home to some earliest world empires. Post LGM expansions into region subsequent population movements created striking genetic mosaic with distinct sex-based differentiation. While prior studies have examined mtDNA Y-chromosome contrast in focal populations East, none undertaken broad-spectrum survey including North sub-Saharan Europe, Eastern populations. In this study...
The manifestation of coronary artery disease (CAD) follows a well-choreographed series events that includes damage arterial endothelial cells and deposition lipids in the sub-endothelial layers. Genome-wide association studies (GWAS) multiple populations with distinctive genetic lifestyle backgrounds are crucial step understanding global CAD pathophysiology. In this study, we report GWAS on basis stenosis as measured by cardiac catheterization Lebanese population. locus phosphatase actin...
Afghanistan has held a strategic position throughout history. It been inhabited since the Paleolithic and later became crossroad for expanding civilizations empires. Afghanistan's location, history, diverse ethnic groups present unique opportunity to explore how nations emerged, major cultural evolutions technological developments in human history have influenced modern population structures. In this study we analyzed, first time, four present-day Afghanistan: Hazara, Pashtun, Tajik, Uzbek,...
Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on basis T2DM in 3,286 Lebanese participants. More than 5,000,000 SNPs were directly genotyped or imputed using 1000 Genomes Project reference panels. identify genome-wide significant variants two loci CDKAL1 TCF7L2, independent sex, age BMI, leading rs7766070 (OR = 1.39, P 4.77 ×...
Background and objectivesHigh homocysteine levels are associated with increased risk of hypertension stroke. Homocysteine is metabolized by the methylenetetrahydrofolate reductase (MTHFR). We aimed to investigate their association hypertension, stroke, antihypertensive medication usage in patients different MTHFR C677T genotypes.Methods resultsGenotype frequency polymorphism was performed, plasma were measured 2,640 adult Lebanese patients. Hypertension, history list medications documented,...
. an der Woude syndrome (VWS, OMIM #119300) is a dominantly inherited developmental disorder characterised by pits and/or sinuses of the lower lip, cleft lip with or without palate (CL/P), isolated (CP), bifid uvula (BU), and hypodontia (H). 1–3 Cleft deformity established during first 6 weeks life due to failure fusion maxillary medial nasal processes incomplete mesodermal ingrowth into processes. Palatal clefts result from palatal shelves that normally change vertical horizontal position...
The burden of diabetes in Lebanon requires well-targeted interventions for screening type 2 mellitus (T2DM) and prediabetes prevention risk factors. Newly recruited 998 Lebanese individuals, addition to 7,292 already available, were studied investigate the prevalence diabetes, their associated Participants had fasting blood sugar glycohemoglobin tests a lipid profile. Clinical demographic information obtained from detailed questionnaire. relationship between T2DM, its factors, complications...
Van der Woude syndrome (VWS), caused by dominant IRF6 mutation, is the most common cleft syndrome. In 15% of patients, lip pits are absent and phenotype mimics isolated clefts. Therefore, we hypothesized that some families classified as having non-syndromic inherited palate could have an mutation. We screened in total 170 patients with or without (CL/P): 75 were syndromic 95 a priori part multiplex families. A mutation was identified 62.7 3.3% respectively. one autosomal inheritance (family...
Cultural, dietary, and lifestyle factors are the main modulators of type 2 diabetes mellitus (T2DM) disease risk. Coffee is one most popular worldwide beverages, recent epidemiological studies have showed that coffee consumption associated with a lower risk T2DM. This study investigates impact intake on T2DM assesses effect CYP variants caffeine exposures Data from 7,607 subjects were analyzed by logistic regression models, among whom 3,290 GWAS data available for association using Plink...
The role of Lipoprotein(a) (Lp(a)) in increasing the risk cardiovascular diseases is reported several populations. aim this study to investigate correlation high Lp(a) levels with degree coronary artery stenosis.Two hundred and sixty-eight patients were enrolled for study. Patients who underwent angiography had measurements available included Binomial logistic regressions applied association between stenosis four major arteries. effect LDL HDL Cholesterol on modulating disease (CAD) was also...
Background Hypoxia, a critical feature during cancer development, leads to the stabilization and activation of hypoxia-inducible factor 1-alpha (HIF-1α) drive expression many target genes which in turn can promote aspects breast biology, mainly metastasis resistance therapy. MicroRNAs are known modulate involved tumorigenesis. In this study, we examined regulatory effect miRNAs on HIF1α expression.
The onset of coronary artery disease (CAD) is influenced by cardiovascular risk factors that often occur in clusters and may build on one another. objective this study to examine the relationship between hypertension CAD age Lebanese population. This retrospective analysis was performed data extracted from patients (n = 3,753). Logistic regression examined association with at diagnosis after controlling for other traditional factors. effect antihypertensive drugs lifestyle changes also...
<h3>Background</h3> The authors observed a patient with cryptic subtelomeric de novo balanced translocation 46,XY.ish t(11;20)(p15.4;q13.2) presenting severe mental retardation, muscular hypotonia, seizures, bilateral sensorineural hearing loss, submucous cleft palate, persistent ductus Botalli, unilateral cystic kidney dysplasia and frequent infections. <h3>Methods Results</h3> Fluorescence in situ hybridisation mapping sequencing of the breakpoints showed that no known genes are disrupted...
The Middle East has the fastest rising rate of Type 2 Diabetes Mellitus (T2DM) worldwide, with Lebanon having 15.8% its population affected. This study aims at studying Polycystic Ovarian Syndrome (PCOS), Gestational (GDM), and macrosomia as risk factors T2DM in Lebanon. Such epidemiological statistical never been conducted before region would be useful for clinical diagnosis. Our cohort is comprised 1453 Lebanese individuals, 897 controls 556 patients. We tested correlation between...