About
Contact & Profiles
A5068297975
Research Areas
- Immune Cell Function and Interaction
- Single-cell and spatial transcriptomics
- T-cell and B-cell Immunology
Carter Center
2022
University of Virginia
2022
Although recent evidence demonstrates heterogeneity among CD8+ T cells during chronic infection, developmental relationships and mechanisms underlying their fate decisions remain incompletely understood. Using single-cell RNA TCR sequencing, we traced the clonal expansion differentiation of LCMV infection. We identified immense phenotypic diversity, including a subset termed intermediate cells. Trajectory analyses infection models showed arise from progenitor before bifurcating into terminal...
10.1084/jem.20220679
article
EN
cc-by-nc-sa
The Journal of Experimental Medicine
2022-10-31
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