A5044473290- Bone fractures and treatments
- Connective tissue disorders research
- Corneal Surgery and Treatments
- MicroRNA in disease regulation
- Developmental Biology and Gene Regulation
- Retinal Development and Disorders
- Zebrafish Biomedical Research Applications
- RNA and protein synthesis mechanisms
- Biotin and Related Studies
- Congenital heart defects research
- Neuroscience and Neuropharmacology Research
- Energy Harvesting in Wireless Networks
- Pancreatic function and diabetes
- Cellular transport and secretion
- Ion Transport and Channel Regulation
- Cancer-related molecular mechanisms research
- Ion channel regulation and function
- Polyomavirus and related diseases
- Animal Genetics and Reproduction
- interferon and immune responses
- Ocular Disorders and Treatments
- Adipose Tissue and Metabolism
- CRISPR and Genetic Engineering
- Glaucoma and retinal disorders
- Full-Duplex Wireless Communications
Penn State Milton S. Hershey Medical Center
2023
Virginia Commonwealth University
2015-2022
Harvard University
2015
Washington University in St. Louis
1992
Understanding how fate specification of distinct cell-types from multipotent progenitors occurs is a fundamental question in embryology. Neural crest stem cells (NCSCs) generate extraordinarily diverse derivatives, including multiple neural, skeletogenic and pigment cell fates. Key transcription factors extracellular signals specifying NCSC lineages remain to be identified, we have only little idea when they function together control fate. Zebrafish three neural crest-derived types, black...
GAP-43 is a neuronal calmodulin-binding phosphoprotein that concentrated in growth cones and presynaptic terminals. By sequencing tryptic endoproteinase Asp-N phosphopeptides directly determining the release of radioactive phosphate, we have identified three sites (serines 41 96 threonine 172) are phosphorylated, both cultured neurons neonatal rat brain. These account for most 32PO4 was incorporated into neurons; 8-15% each site occupied with phosphate isolated from Phosphorylation serine...
A critical step in eye development is closure of the choroid fissure (CF), a transient structure ventral optic cup through which vasculature enters and ganglion cell axons exit. While many factors have been identified that function during CF closure, molecular cellular mechanisms mediating this process remain poorly understood. Failure results colobomas. Recently, MITF was shown to be mutated subset human coloboma patients, but how functions unknown. To address question, zebrafish with...
Abstract The developmental process of central nervous system (CNS) myelin sheath formation is characterized by well‐coordinated cellular activities ultimately ensuring rapid and synchronized neural communication. During this process, myelinating CNS cells, namely oligodendrocytes (OLGs), undergo distinct steps differentiation, whereby the progression earlier maturation stages OLGs represents a critical step toward timely establishment myelinated axonal circuits. Given complexity functional...
Understanding how fate specification of distinct cell-types from multipotent progenitors occurs is a fundamental question in embryology. Neural crest stem cells (NCSCs) generate extraordinarily diverse derivatives, including multiple neural, skeletogenic and pigment cell fates. Key transcription factors extracellular signals specifying NCSC lineages remain to be identified, we have only little idea when they function together control fate. Zebrafish three neural crest-derived types, black...
Abstract A critical step in eye development is closure of the choroid fissure (CF), a transient structure ventral optic cup through which vasculature enters and ganglion cell axons exit. While many factors have been identified that function during CF closure, molecular cellular mechanisms mediating this process remain poorly understood. Failure results colobomas. Recently, MITF was shown to be mutated subset human coloboma patients, but how functions unknown. To address question, zebrafish...