A5046462982- Estrogen and related hormone effects
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Immune Response and Inflammation
- Peroxisome Proliferator-Activated Receptors
- Immune Cell Function and Interaction
- Parasitic Infections and Diagnostics
- Histone Deacetylase Inhibitors Research
- Immunotherapy and Immune Responses
- Retinoids in leukemia and cellular processes
- Heat shock proteins research
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Asthma and respiratory diseases
- Stress Responses and Cortisol
- T-cell and B-cell Immunology
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Malaria Research and Control
- Allergic Rhinitis and Sensitization
- Multiple Myeloma Research and Treatments
- Nuclear Receptors and Signaling
Cancer Research Institute Ghent
2016-2025
Ghent University
2016-2025
VIB-UGent Center for Medical Biotechnology
2016-2025
Vlaams Instituut voor Biotechnologie
1998-2024
Allegheny Health Network
2022
Weatherford College
2022
VIB-UGent Center for Inflammation Research
2020
Ghent University Hospital
2009-2017
Memorial Sloan Kettering Cancer Center
2013
Chang Gung Memorial Hospital
2012
Interleukin-6 (IL-6) is a pleiotropic cytokine, whose plasma levels are elevated in inflammatory diseases such as atherosclerosis. We have previously reported that peroxisome proliferator-activated receptor alpha (PPARalpha) ligands (fibrates) lower concentrations of IL-6 patients with atherosclerosis and inhibit IL-1-stimulated secretion by human aortic smooth muscle cells (SMC). Here, we show explants isolated from PPARalpha-null mice display an exacerbated response to stimuli,...
Interleukin-6 (IL-6) is a pleiotropic cytokine, which involved in inflammatory and immune responses, acute phase reactions, hematopoiesis. In the mouse fibrosarcoma cell line L929, nuclear factor (NF)-κB plays crucial role IL-6 gene expression mediated by tumor necrosis (TNF). The levels of activated do not, however, correlate with variations transcription; therefore, other factors and/or regulatory mechanisms presumably modulate mRNA production. Upon analysis various deletion point-mutated...
Glucocorticoids exert multiple anti-inflammatory activities, one of which is the inhibition transcription dependent on nuclear factor (NF)-κB. It has been suggested that effect dexamethasone (DEX), a glucocorticoid analog, attributed to an increased production inhibitory IκB molecule, in turn would bind and remove activated, DNA-bound NF-κB complexes cell nucleus. Upon investigating DEX-mediated repression interleukin-6 expression induced by tumor necrosis factor, DEX treatment was found act...
Expression of the pleiotropic cytokine interleukin (IL)-6 can be stimulated by proinflammatory tumor necrosis factor (TNF) and microbial alkaloid staurosporine (STS). In this report, transcriptional mechanisms were thoroughly investigated. Whereas transcription factors binding to activator protein-1-, cAMP-responsive element-, CAAT enhancer-binding protein-responsive sequences are necessary for gene activation STS, nuclear (NF)-kappaB alone is responsible sufficient inducibility TNF, which...
Glucocorticoids (GCs) are used to combat inflammatory diseases. Their beneficial effect relies mainly on the inhibition of NF-κB- and/or AP-1-driven proinflammatory gene expression. Previously, we have shown that GCs repress tumor necrosis factor-induced IL-6 expression by an NF-κB-dependent nuclear mechanism without changing DNA-binding capacity NF-κB or levels cytoplasmic inhibitor (IκB-α). In present work, investigate GC repression different natural recombinant NF-κB-driven reporter...
The identification of selective glucocorticoid receptor (GR) modifiers, which separate transactivation and transrepression properties, represents an important research goal for steroid pharmacology. Although the gene-activating properties GR are mainly associated with undesirable side effects, its negative interference activity transcription factors, such as NF-κB, greatly contributes to antiinflammatory immune-suppressive capacities. In present study, we found that Compound A (CpdA), a...