A5004381584- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Gastroesophageal reflux and treatments
- Neuroendocrine Tumor Research Advances
- Lung Cancer Treatments and Mutations
- Metastasis and carcinoma case studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Adrenal and Paraganglionic Tumors
- Anorectal Disease Treatments and Outcomes
- Multiple and Secondary Primary Cancers
- Eosinophilic Esophagitis
- Pituitary Gland Disorders and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Chemokine receptors and signaling
- Gastrointestinal Tumor Research and Treatment
- Diverticular Disease and Complications
Johannes Gutenberg University Mainz
2013-2023
University Medical Center of the Johannes Gutenberg University Mainz
2010-2023
University Medical Center
2020
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
1989-2015
Vivantes Klinikum
2014
Charité - Universitätsmedizin Berlin
2014
Carl-Thiem-Klinikum Cottbus
2014
Sine Institute
2010
LMU Klinikum
2010
Heidelberg University
2007
Abstract Purpose: The expression of chemokine receptors CXCR4 and CCR7 has been associated with tumor dissemination poor prognosis in a limited number entities. However, no data are currently available on the impact receptor disease progression human colorectal cancer. Experimental Design: was evaluated 96 patients histologically confirmed cancers four cancer cell lines by immunohistochemical staining. Furthermore, migration assays were done SW480, SW620, LS174T cells to confirm effect...
In different tumour entities, expression of the chemokine receptor 4 (CXCR4) has been linked to dissemination and poor prognosis. Therefore, we evaluated, if CXCR4 exerts similar effects in human hepatocellular carcinoma (HCC). Expression analysis functional assays were performed vitro elucidate impact CXCL12 on hepatoma cells lines. addition, was evaluated 39 patients with HCC semiquantitatively correlated both, characteristics. Human cell lines displayed variable intensities expression....
Prognosis after surgical therapy for pancreatic cancer is poor and has been attributed to early lymph node involvement as well a strong tendency of cells infiltrate into the retropancreatic tissue spread along peripancreatic neural plexuses. The objective our study was classify anatomical-surgical layer mesopancreas describe principles relevant resection (RMP). Immunohistochemical investigation mesopancreatic-perineural lymphogenic structures carried out with purpose identifying possible...
Abstract Background It is not clear whether all patients with rectal cancer need chemoradiotherapy. A restrictive use of neoadjuvant chemoradiotherapy (nCRT) based on MRI findings for was investigated in this study. Methods This prospective multicentre observational study included stage cT2–4 cancer, any cN and cM0 status. Carcinomas the middle lower third that were 1 mm or less from mesorectal fascia, cT4 tumours, cT3 tumours classified as high risk, these received nCRT followed by total...
We investigated whether neoadjuvant chemoradiotherapy (nCRT) in patients with rectal cancer can be restricted to those at high risk of locoregional recurrence (LR) without compromising oncological outcomes.In a prospective multicenter interventional study, (cT2-4, any cN, cM0) were classified according the minimal distance between tumor, suspicious lymph nodes or tumor deposits, and mesorectal fascia (mrMRF). Patients >1 mm underwent up-front total excision (TME; low-risk group), whereas ≤1...
Local excision of early rectal cancer is a controversial issue, which in part because differences the evaluation histopathologic criteria. This prospective study was designed to determine prognostic factors for recurrences and need reoperation.In 105 118 patients with pT1 carcinomas local excision, results recurrence rates ten-year cancer-free survival were studied separately according different histologic criteria (R0, R1, Rx, R < or = 1 mm, high-/low-risk situation), tumor localization...
Given the improvement in oncologic outcome after introduction of total mesorectal excision for treatment rectal cancer, objective present study was to determine frequency identification and preservation pelvic autonomic nerves identify a possible link between postoperative micturition disturbances extent radical resection.Between March 1997 December 2001, 150 patients with adenocarcinoma rectum (<or=16 cm from anal verge) underwent surgery, sphincter 112 cases (74.7 percent). Sixty-three (42...
An open-label randomised comparison of efficacy and tolerability irinotecan plus high-dose 5-fluorouracil (5-FU) leucovorin (LV) (ILF) with etoposide 5-FU/LV (ELF) in patients untreated metastatic or locally advanced gastric cancer. One cycle ILF comprised six once-weekly infusions 80 mg m−2, LV 500 24-h 5-FU 2000 ELF three once-daily doses 120 300 m−2. In all, 56 received 58 ELF. Median age was 62 years, Karnofsky performance 90%, disease status comparable for both arms. The objective...
The etiology of achalasia is still unknown. current theories chronic inflammation leading to autoimmune response with destruction and loss the inhibitory myenteric ganglion cells enlighten its pathogenesis in a limited way only. Interstitial Cajal (ICC) have been shown be involved nitrergic neurotransmission lower esophageal sphincter (LES).To investigate significance ICC neuronal nitric oxide synthase (n-NOS) wall tissue patients undergoing surgery for achalasia.In 53 median age 45 (6-78)...
<i>Aim:</i> Patients were analyzed who underwent treatment of liver metastases from pancreatic cancer. <i>Methods:</i> Selection criteria the possibility R0 resection primary and/or metastases, no other sites and presentation metastases. A comparison by surgery versus chemotherapy regarding overall survival disease-free interval was performed. <i>Results:</i> Between 1996 2008, a total number 23 patients retrospectively identified prospective database 193...
BACKGROUND AND OBJECTIVES: A low anterior resection procedure for removing a rectal tumor aims to preserve the sphincter and avoid permanent stoma. Permanent stomas are primarily necessary in cases of poor anorectal function local recurrence. The aim this study was clarify whether anastomosis-related complications recurrence influenced rate long-term follow-up. METHODS: Of 1032 consecutive patients with cancer, 397 were treated by (R0 R1 resections) between 1985 2007 at Department General...
Purpose To assess pretreatment functional and morphological tumor characteristics with magnetic resonance imaging (MRI) in advanced rectal carcinoma to identify factors predicting response neoadjuvant chemoradiation. Materials Methods In a prospective study, 95 patients underwent dynamic contrast-enhanced MRI before after Quantitative parameters were derived from pharmacokinetic two-compartment model. Tumors also characterized regard mucinous status at high-resolution as nonmucinous or...
The study was aimed to identify pre- and intraoperative risk factors that potentially influence morbidity mortality after esophagectomy for esophageal carcinoma with particular emphasis on the predominant tumor types.Between September 1985 March 2004, 424 patients underwent carcinoma. Of these, 186 (43.9%) had a transhiatal, 231 (54.5%) transthoracic procedure two-field lymphadenectomy. Pre-, characteristics were included in analysis assess their postoperative mortality.Multivariate...
The etiology of achalasia is still unknown. aim the present study was to elucidate its underlying pathologies and their chronology by investigation esophageal specimens in patients undergoing surgery (esophageal resection or myotomy) for achalasia.In 17 with achalasia, histopathologic examinations wall focussing on myenteric plexus were performed. Preoperative diagnosis based clinical evaluation, esophagogastroscopy, barium esophagogram all, manometry eight patients. median age at time 54...
In previous studies, local excision was predominantly established for "low-risk" pT1 rectal cancer. The results obtained with T2 tumors are unclear; recurrence rates of 0 to 67 percent were reported. This study designed determine the value carcinomas, prognostic factors, and need reoperation.After 649 patients tumors, pT2 carcinoma found in 44 patients. general, immediate reoperation recommended; however, 24 declined further surgery or not reoperated because comorbidities. analyzed...