Topical forms of Non-steroidal anti-inflammatory drugs (NSAIDs) used to treat pain, fever and inflammation ensure reduced occurrence systemic adverse effects that are common with oral application. Compared the therapy, topical applications NSAIDs require lower doses achieve pain relief, thus pose risk major drug interactions. We aimed evaluate analgesic diclofenac ketoprofen patch in rat model acute inflammation. Wistar male rats, body weight 220–290 g were randomized into five groups six...

The open prospective combined cytogenetic and clinical study investigated the impact of biological therapy Rituximab on number structure chromosomes in Rheumatoid arthritis patients.The purpose this was to investigate safety as well cytotoxic Methotrexate.A total 8 seropositive patients were analyzed for primary end point eventual effect Rituximab. Assessment done before 1 month later, actually 2 weeks after administration full course infusion. Patients suffering from active randomly...

Autoimmune diseases occur in 3-5% of the population. Study included 30 patients with clinically diagnosed SLE and healthy controls (American college Rheumatology, 1997). was according to criteria issued 1997 by American College Rheumatology (ACR). The aim this study evaluate concentration values each antigen ENA-6 profile SLE, investigate possible correlation between Sm antibodies CIC, test their use as immunobiological markers SLE. Furthermore, our determine whether there is a CIC activity....

Cytokines exert biological function through signal transducer and activator of transcription factors. Prostaglandins have as promotors, where play a key role in generation the inflammatory response ones that solve process.Non-steroidal anti-inflammatory drugs, inhibit prostaglandin synthesis but existence additional mechanisms is present. Thus, we aimed to explore effects topically applied NSAIDs on levels PGE2 Stat3 setting two vivo induced acute inflammation models.Male Wistar rats were...

Introduction: The met-enkephalin (1-5 Adrenorphin) and tridecactide (alpha-corticotropin 1-13) combination is used in the multiple sclerosis (MS) immuno-modulatory treatment. A testing of cytogenetic effects resulted reductions lymphocytic aberrations lymphocytes peripheral blood (PBL) patients with immune-mediated diseases. aim this research to evaluate vitro on number type chromosome PBL MS patients. 
 Methods: We samples from seven female diagnosis based a McDonald Diagnostic...

The aim of this study was to determine the value micronuclei test (MN) on peripheral blood lymphocytes from 200 healthy participants both gender general population FB&H, as well if gender, age or smoking habit have influence MN frequency. Standard protocol for cultivating and analyzing binuclear been applied. Results presented that range singe values are 0 8 in 1000 cells. It has determined do frequency, especially 2 frequencies. Females average higher all variables than men. proven...

Background: Thiomersal is used as a preservative of some vaccines or trace from the pathogen inactivation process in vaccine production. Prophylactic use paracetamol upon vaccination still common, even though decreases immune response on vaccines. Considering cytotoxic and genotoxic potential thiomersal possible interaction vivo, vitro study was performed. Methods: The effects combination were examined human lymphocyte cultures by using two methods: analysis chromosomal aberrations...

Aims: Cystic fibrosis is an autosomal recessive multisystem disease caused by a mutation of the CFTR gene. To date, more than 1900 mutations this gene are known. Studies have shown that most common delF508. In Bosnia and Herzegovina, prevalence individual in general population has not been thoroughly studied, so study aimed to determine concerning countries region rest world.
 Study Design: Retrospective study.
 Place Duration Study: Thirty-nine subjects with suspected were...

Background: Patients with multiple myeloma are characterized by increased production of light chains immunoglobulins and thus increase in the concentration proximal nephron tubule lumen that leads to renal injury. Methods: This cross-sectional study involved 62 patients MM. They were three different stage groups disease using Salmon-Durie classification International Staging System (ISS). Blood samples drawn measure Cystatin C, Immunoglobulins, Free (FLC), C-reactive protein (CRP),...

Background: Thimerosal is an organomercury compound with high mercury content. located in the market as effective bacteriostatic a series of pharmaceutical products, ophthalmic and nasal immunoglobulin preparations, preservative vaccines. Aims Objectives: Since it living content, this study aimed to examine genotoxic cytotoxic potential thimerosal human lymphocytes culture. Materials Methods: We used chromosome aberration analysis cytokinesis-block micronucleus cytome (CBMN-Cyt) assay test...

The aim of this study was to determine the values micronuclei (MN) and structural chromosomal aberrations (CA) in peripheral blood lymphocytes from 200 healthy participants both genders general population FB&H, as well explore influence gender age on MN CA frequencies. Standard protocols for test, cultivation analysis binuclear have been applied. ranged 0 8 per 1000 cells. results suggest that frequency, with pronounced effect 2 Females average higher all observed variables test than...

Background: Multiple myeloma (MM) is a disease of B cell population with excessive secretion immunoglobulins and presence free light chains (FLCs) that are by products immunoglobulin synthesis. Free play crucial role in causing renal damage. Interleukine-6 (IL-6) supports the survival and/or expansion MM cells stimulating as well preventing programmed death.
 Aims Objectives: The aim this study was to evaluate serum urine (FLC)measurement compare IL-6 levels patients different stages...

Background: Thimerosal is an organomercury compound with high mercury content. located in the market as effective bacteriostatic a series of pharmaceutical products, ophthalmic and nasal immunoglobulin preparations, preservative vaccines. Aims Objectives: Since it living content, this study aimed to examine genotoxic cytotoxic potential thimerosal human lymphocytes culture. Materials Methods: We used chromosome aberration analysis cytokinesis-block micronucleus cytome (CBMN-Cyt) assay test...

Educational interventions have already been shown to positively affect awareness of clinical trials (CTs) among medical students. We aimed explore basic knowledge and attitudes about CTs students in terms educational that should be reflected their further involvement performing role raising CTs.This cross-sectional, self-report anonymous online survey involved undergraduate the Medical Faculty University Sarajevo enrolled classes held within Department Pharmacology Toxicology academic year...