A5067135525- Molecular Sensors and Ion Detection
- Chemical Synthesis and Analysis
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Asymmetric Synthesis and Catalysis
- Analytical Chemistry and Chromatography
- Supramolecular Chemistry and Complexes
- Luminescence and Fluorescent Materials
- Chemical Synthesis and Reactions
- Synthetic Organic Chemistry Methods
- Lipid Membrane Structure and Behavior
- Supramolecular Self-Assembly in Materials
- Analytical Chemistry and Sensors
- Advanced biosensing and bioanalysis techniques
- Organic Chemistry Cycloaddition Reactions
- Crystallography and molecular interactions
- Molecular spectroscopy and chirality
- Electrochemical Analysis and Applications
- Click Chemistry and Applications
- Porphyrin and Phthalocyanine Chemistry
- Drug Transport and Resistance Mechanisms
- Organoboron and organosilicon chemistry
- Organic and Inorganic Chemical Reactions
University of Bristol
2016-2025
Royal Society of Chemistry
2023
University of Pittsburgh
2023
Tsinghua University
2023
University of Toronto
2023
University of Manchester
2023
Boston College
2023
University of Padua
2023
East China Normal University
2023
Indian Institute of Science Bangalore
2023
Carbohydrates are not always as "sticky" one might expect. Even in organic solvents they difficult targets for the supramolecular chemist, due to their complex, three-dimensional structures. In natural environment (water) especially elusive, presenting challenges which will occupy synthetic and theoretical chemists some time come. The complex of an octaamide receptor with beta-D-glucopyranose, binds through apolar polar contacts, is shown.
The fluorescent photoinduced electron transfer (PET) chemosensors 2 and 3 were designed for the recognition of anions possessing two binding sides such as dicarboxylates pyrophosphate; anion in DMSO takes place through charge neutral thiourea receptor sites with concomitant PET quenching anthracene moiety. acetate, phosphate, pyrophosphate to was also evaluated by using 1H NMR DMSO-d6.
Carbohydrate recognition is biologically important but intrinsically challenging, for both nature and host-guest chemists. Saccharides are complex, subtly variable, camouflaged by hydroxyl groups that hinder discrimination between substrate water. We have developed a rational strategy the biomimetic of carbohydrates with all-equatorial stereochemistry (beta-glucose, analogs, homologs) now applied it to disaccharides such as cellobiose. Our synthetic receptor showed good affinities, not...
We demonstrate for the first time that charge neutral anthracene based fluorescent sensors 1a–c, having an aromatic or aliphatic thiourea moiety as anion receptor, show ideal PET sensor behaviour where fluorescence emission is selectively quenched upon titration with AcO−, H2PO4− and F− but not by Cl− Br− in DMSO.
The synthesis of four fluorescent photoinduced electron transfer (PET) chemosensors 1–4 for anions is described. These are all based on a simple design employing charge neutral aliphatic or aromatic thiourea anion receptors connected to an anthracene fluorophore via methylene spacer. Here the recognition occurred through 1 : hydrogen bonding between protons and anion, as demonstrated by observing changes in 1H NMR DMSO-d6 where two were shifted downfield upon addition anions. Whereas 1–3...
The synthesis of the fluorescent photoinduced electron transfer (PET) chemosensors 1-3 for bis-anions such as bis-carboxylates and pyrophosphate in organic solvents is described herein. These sensors are based on receptor-spacer-fluorophore-spacer-receptor motif where receptors charge neutral aromatic thiourea or urea fluorophore anthracene. anion recognition was evaluated using 1H NMR well absorption fluorescence spectroscopy DMSO. For simple anions acetate fluoride, shown to be through...
A fluorescent assay based on the chloride-sensitive probe, lucigenin, is developed for monitoring chloride transport into vesicles, and used to compare effectiveness of three steroid-derived transporters.
Biotin[6]uril hexaesters represent a new class of anionophores which operate solely through C—H···anion interactions. The use soft H-bond donors favors the transport less hydrophilic anions (e.g., Cl–, NO3–) over hard, stongly hydrated HCO3– and SO42–). Especially relevant is selectivity between chloride bicarbonate, major inorganic in biological systems.
The pyrene nucleus is a valuable component for materials, supramolecular and biological chemistry, due to its photophysical/electronic properties extended rigid structure. However, exploitation hindered by the limited range of methods outcomes direct substitution itself. In response this problem, variety indirect have been developed preparing pyrenes with less usual patterns. Herein we review these approaches, covering which involve reduced pyrenes, transannular ring closures cyclisations...
Exceptionally powerful anion receptors have been constructed by placing squaramide groups in axial positions on a steroidal framework. The steroid preorganizes the NH such that they can act cooperatively bound anion, while maintaining solubility nonpolar media. acidic confer higher affinities than previously-used ureas or thioureas. Binding constants exceeding 10(14) M(-1) measured for tetraethylammonium salts chloroform employing variation of Cram's extraction procedure. also studied as...
In one fell swoop, polyrotaxanes comprising up to 64 rings can be synthesized as a result of cucurbit[6]uril-templated 1,3-dipolar azide-alkyne cycloadditions accelerated in the presence cyclodextrins consequence self-sorting and positive cooperativity, brought about by hydrogen bonding. Mixing six components (see picture) pot affords hetero[4]rotaxane minute quantitative yield.
The natural product Valinomycin is a well-known transmembrane cation carrier. Despite being uncharged, this molecule can extract potassium ions from water without counterions and ferry them through membrane interior. Because it only transports positive ions, electrogenic, mediating flow of charge across the membrane. Equivalent agents for anions would be valuable research tools may have therapeutic applications, especially in treatment "channelopathies" such as cystic fibrosis. However, no...