A5102873114- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Sociology and Education Studies
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Integrated Circuits and Semiconductor Failure Analysis
- Phytochemistry Medicinal Plant Applications
- Semiconductor materials and devices
- Herpesvirus Infections and Treatments
- CAR-T cell therapy research
- Electron and X-Ray Spectroscopy Techniques
- Inflammasome and immune disorders
- Advanced Battery Materials and Technologies
- Laser Material Processing Techniques
- IL-33, ST2, and ILC Pathways
- Single-cell and spatial transcriptomics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Public Administration and Political Analysis
- Fuel Cells and Related Materials
- Criminal Law and Policy
- Innovative Teaching Methodologies in Social Sciences
- Law and Political Science
- Phytochemistry and biological activity of medicinal plants
- Essential Oils and Antimicrobial Activity
- Eosinophilic Esophagitis
Friedrich-Alexander-Universität Erlangen-Nürnberg
2023
Universitätsklinikum Erlangen
2023
Institute of Medical Microbiology and Hygiene
2020-2022
Technical University of Munich
2012-2022
Control Vision (United States)
2008
Background COVID-19 has so far affected more than 250 million individuals worldwide, causing 5 deaths. Several risk factors for severe disease have been identified, most of which coincide with advanced age. In younger individuals, often occurs in the absence obvious comorbidities. Guided by finding cytomegalovirus (CMV)-specific T cells some cross-reactivity to SARS-CoV-2 a intensive care unit (ICU) patient, we decided investigate whether CMV seropositivity is associated or critical...
The in vivo phenotypic profile of T cells reactive to severe acute respiratory syndrome (SARS)-CoV-2 antigens remains poorly understood. Conventional methods detect antigen-reactive require vitro antigenic re-stimulation or highly individualized peptide-human leukocyte antigen (pHLA) multimers. Here, we use single-cell RNA sequencing identify and SARS-CoV-2-reactive from Coronavirus Disease 2019 (COVID-19) patients. To do so, induce transcriptional shifts by stimulation take advantage...
T cell immunity is crucial for control of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and has been studied widely on a quantitative level. However, the quality responses, in particular CD8+ cells, only investigated marginally so far. Here, we isolate receptor (TCR) repertoires specific immunodominant SARS-CoV-2 epitopes restricted to common human Leukocyte antigen (HLA) class I molecules convalescent individuals. SARS-CoV-2-specific cells are detected up 12 months...
Inflammatory bowel diseases (IBD) are characterized by mucosal inflammation and sequential fibrosis formation, but the exact role of hyperactive NLRP3 inflammasome in these processes is unclear. Thus, we studied expression function context IBD. We analysed intestinal immune cells fibroblasts from IBD patients NLRP3-associated gene via single-cell RNA sequencing microarray analyses. Furthermore, cytokine secretion inhibitor treated blood cells, as well proliferation, collagen production, cell...
ABSTRACT The in vivo phenotypic profile of T cells reactive to severe acute respiratory syndrome (SARS)-CoV-2 antigens remains poorly understood. Conventional methods detect antigen-reactive require vitro antigenic re-stimulation or highly individualized peptide-human leukocyte antigen (pHLA) multimers. Here, we used single-cell RNA sequencing identify and SARS-CoV-2-reactive from Coronavirus Disease 2019 (COVID-19) patients. To do so, induced transcriptional shifts by stimulation took...
ABSTRACT T cell immunity is crucial for the control of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and has been widely characterized on a quantitative level. In contrast, quality such responses poorly investigated, in particular case CD8 + cells. Here, we explored SARS-CoV-2-specific individuals who recovered from mild symptomatic infections, through which protective should develop, by functional characterization their receptor (TCR) repertoire. specific...
Mari-mari (Cassia leiandra Benth.) is an Amazonian native fruit that highly appreciated in the northern region of Brazil, but there are few studies regarding its chemical composition and/or biological properties. A phytochemical study was conducted on extracts pulp, peel and seeds; their antioxidant, cytotoxic antimicrobial potential were also determined. Methanol acetone from different parts subjected to total phenolic, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging FeIII reducing...
Abstract Der Vorzug des telezentrischen Strahlengangs zur Erhöhung der Messgenauigkeit ist allgemein bekannt [1]. Oft aber wird in Bildverarbeitungspraxis nach dem Telezentriebereich gefragt. Dafür wünscht man sich die Angabe eines Intervalls entlang optischen Achse, innerhalb dessen Bildverarbeitungsanlage „fehlerfrei”︁ misst. Ausgehend vom Telezentriefehler Messobjektivs und Schärfentiefenbereich bei Bildaufnahme durch elektronische Kamera werden Einflüsse quantifiziert, den festlegen.
Ainda é cedo para uma avaliação precisa sobre os impactos da pandemia Covid -19 na escola, como ela envolveu seus diferentes agentes (estudantes, professores, funcionários e famílias), mas fato que o tempo de afastamento físico do ambiente escolar trouxe muitos reflexos sala aula vida dos membros Comunidade Escolar. O ano 2022 marcou a retomada das atividades presenciais forma plena já não mesma antes que, agora, exige suas lideranças resgate práticas cotidiano comprovada eficácia, aliadas à...
ABSTRACT Background COVID-19 has so far affected more than 250 million individuals worldwide, causing 5 deaths. Several risk factors for severe disease have been identified, most of which coincide with advanced age. In younger individuals, often occurs in the absence obvious comorbidities. Guided by finding cytomegalovirus (CMV)-specific T cells some cross-reactivity to SARS-CoV-2 a intensive care unit (ICU) patient, we decided investigate whether CMV seropositivity is associated or critical...