A5038039427- Congenital Heart Disease Studies
- Congenital Diaphragmatic Hernia Studies
- Bacterial biofilms and quorum sensing
- Cardiovascular Issues in Pregnancy
- Antibiotic Resistance in Bacteria
- Bacterial Genetics and Biotechnology
- Pregnancy and preeclampsia studies
- Pediatric Urology and Nephrology Studies
- Ophthalmology and Eye Disorders
- Nuclear reactor physics and engineering
- Cardiac Structural Anomalies and Repair
- Legionella and Acanthamoeba research
- Lymphatic System and Diseases
- Advanced Differential Geometry Research
- Urinary Tract Infections Management
- Oral microbiology and periodontitis research
- Urinary Bladder and Prostate Research
- Lymphatic Disorders and Treatments
University of Copenhagen
2022-2024
Copenhagen University Hospital
2022-2024
Rigshospitalet
2022-2024
ABSTRACT The cell-to-cell communication system quorum sensing (QS), used by various pathogenic bacteria to synchronize gene expression and increase host invasion potentials, is studied as a potential target for persistent infection control. To search novel molecules targeting the QS in Gram-negative opportunistic pathogen Pseudomonas aeruginosa , chemical library consisting of 3,280 small compounds from LifeArc was screened. A series 10 conjugated phenones that have not previously been...
We do not know if children born with a simple or uncorrected congenital heart disease (CHD) have school performance issues and an increased need for special education compared to healthy peers. With this study we examine the in both complex CHD. Further, evaluate exposure preeclampsia smoking affects education.In nation-wide population based registry study, included all Danish CHD 1994-2012. In addition ten age gender matched control per child were included. Non-singletons syndrome excluded....
Background In the palliative pathway of single-ventricle physiology, lymphatic abnormalities on T2-weighted magnetic resonance imaging have been shown after Glenn operation. It is believed that postsurgical hemodynamic changes contribute to changes.However, little known about how early these occur. Our purpose was determine if occur as before Methods and Results We retrospectively reviewed patients with physiology a scan their operation (superior cavopulmonary connection) at The Children's...
Acute pyelonephritis is one of the most common bacterial infections in childhood. This potentially serious condition can lead to renal scarring, loss kidney function and hypertension. The aim this study was identify risk factors associated with children without or urinary tract abnormalities.Medical records aged 4-18 diagnosed 1st time from 2016 2021 were retrospectively analysed. Children abnormal ultrasound excluded. In addition demographic data, information on bladder bowel extracted...
Our primary aim was to examine whether exposure pre-eclampsia increases the risk of neurodevelopmental disorders in children born with congenital heart disease (CHD). secondary evaluate CHD and may act synergy potentiate this risk.Using population-based registries, we included all Danish between 1994 2017. Non-singletons a syndrome were excluded. Neurodevelopmental including attention-deficit/hyperactivity disorder, autism spectrum disorders, tic identified use 10th edition International...
Abstract The lymphatic system is compromised in different groups of patients. To recognize pathology, we must know what healthy. We use Near‐Infrared Fluorescence (NIRF) to assess peripheral function humans. have shown that external factors such as exercise, hyperthermia, and pharmacological mediators influence the vessels. In this study, explored impact on vessels by ever‐present factor— gravity . used NIRF imaging investigate changes gravity. Gravity was assessed changing body position...
Our objective was to investigate if an increased nuchal translucency (NT) associated with higher mortality in chromosomally normal children congenital heart defects (CHD).In a nationwide cohort using population-based registers, we identified 5,633 liveborn Denmark pre- or postnatal diagnosis of CHD from 2008 2018 (incidence 0.7%). Children chromosomal abnormalities and non-singletons were excluded. The final compromised 4,469 children. An NT defined as > 95th-centile. 95th-centile vs. <...
Background Studies show that an impaired maternal–fetal environment (iMFE) increases the mortality risk in children with single‐ventricle congenital heart defects (CHDs). We investigated impact of iMFE on death various surgically corrected CHDs. Methods and Results In this nationwide register‐based study, we examined association between (including preeclampsia, gestational hypertension, diabetes, maternal smoking during pregnancy) a large cohort CHDs Denmark (1994–2018). Survival analysis...
ABSTRACT The cell-to-cell communication system quorum sensing (QS), used by various pathogenic bacteria to synchronize gene expression and increase host invasion potentials, is studied as a potential target for persistent infection control. To search novel molecules targeting the QS in Gram-negative opportunistic pathogen Pseudomonas aeruginosa chemical library consisting of 3280 small compounds from LifeArc was screened. A series ten conjugated phenones that have not previously been...