A5047370784- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Neurological disorders and treatments
- Attention Deficit Hyperactivity Disorder
- Diet and metabolism studies
- Stress Responses and Cortisol
- Mitochondrial Function and Pathology
- Amino Acid Enzymes and Metabolism
- Neuroendocrine regulation and behavior
- Mental Health Research Topics
- Treatment of Major Depression
- Autism Spectrum Disorder Research
- Metabolism and Genetic Disorders
- Phosphodiesterase function and regulation
- Obsessive-Compulsive Spectrum Disorders
- Bioinformatics and Genomic Networks
- EEG and Brain-Computer Interfaces
- Birth, Development, and Health
- Digital Mental Health Interventions
- Chemical Safety and Risk Management
University of Naples Federico II
2019-2025
Federico II University Hospital
2018-2025
Translational Research in Oncology
2023
Sapienza University of Rome
2019
Abstract Background The neurobiology underlying treatment-resistant schizophrenia (TRS) has not been fully elucidated1. This project provides a preliminary dissection of the neurobiological underpinnings cognitive dysfunction in (SCZ), such as disorganization factor, core clinical and pathophysiological correlate TRS2. In this context, TRS shows putative unique neuroimaging correlates compared to treatment-responsive (non-TRS)3, probably related specific functional disconnection patterns,...
Treatment-resistant schizophrenia (TRS) occurs when symptoms persist despite adequate antipsychotic treatment in terms of both timing and dosage. This severe condition is often overlooked, the existence guidelines, with an average delay 4-9 years before introduction clozapine, gold standard treatment. We hypothesized that patients autistic are more prone to develop TRS. To test this, we administered Positive Negative Syndrome Scale for Schizophrenia Autism Severity (PAUSS) 117 diagnosed...
Abstract Background Schizophrenia is a worldwide severe mental illness in which alterations at the synaptic level play an essential role underpinning neuropathology [1]. Impairments spines result ineffective data processing whole brain with detrimental effects on network measures Aberrant and integration of neuronal information could directly lead to onset psychotic symptoms by affecting functioning Central Executive, Salience, Default Mode Network [2]. Aims The present work aims explore...
Abstract Background Stress is responsible for impacting brain regions’ synaptic changes and functional connectivity modifications that hesitate in several cognitive processes such as spatial declarative memory, fear, memories of emotionally charged events, executive functions fear extinction are all cross-functional the functioning neurodevelopmental disorders. Aims We investigated transcript Homer1a, an Immediate Early Gene, which encodes a crucial molecule dendritic spine involved...
Few longitudinal studies have so far investigated the impact of sustained COVID-19 among people with pre-existing psychiatric disorders. We conducted a prospective study involving serious mental illness (n = 114) and healthy controls 41) to assess changes in Perceived Stress Scale, Generalized Anxiety Disorder Patient Health Questionnaire, Specific Psychotic Experiences Questionnaire scores 18 months after pandemic outset. Subjects underwent interviews health professional April 2020 at end...
Background: Antipsychotic agents modulate key molecules of the postsynaptic density (PSD), including Homer1a gene, implicated in dendritic spine architecture. How antipsychotic receptor profile, dose, and duration administration may influence synaptic plasticity pattern expression is yet to be determined. Methods: In situ hybridization for was performed on rat tissue sections from cortical striatal regions interest (ROI) after acute or chronic three antipsychotics with divergent profile:...
Although antipsychotics’ mechanisms of action have been thoroughly investigated, they not fully elucidated at the network level. We tested hypothesis that acute pre-treatment with ketamine (KET) and administration asenapine (ASE) would modulate functional connectivity brain areas relevant to pathophysiology schizophrenia, based on transcript levels Homer1a, an immediate early gene encoding a key molecule dendritic spine. Sprague–Dawley rats (n = 20) were assigned KET (30 mg/kg) or vehicle...