A5027558065- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Child Nutrition and Water Access
- Dermatology and Skin Diseases
- Trace Elements in Health
- Iron Metabolism and Disorders
Radboud University Medical Center
2015-2025
Radboud University Nijmegen
2015-2025
Sint Maartenskliniek
2019-2023
University Medical Center
2021-2022
Sint Maartenskliniek
2019-2022
Radboud Institute for Molecular Life Sciences
2015-2021
Massachusetts General Hospital
2015
Orally administrated iron is suspected to increase susceptibility enteric infections among children in infection endemic regions. Here we investigated the effect of dietary on pathology and local immune responses intestinal models. Mice were held iron-deficient, normal iron, or high diets after 2 weeks they orally challenged with pathogen Citrobacter rodentium. Microbiome analysis by pyrosequencing revealed profound iron- infection-induced shifts microbiota composition. Fecal levels innate...
To explore the extent to which skin severity is reflected in Psoriatic arthritis Disease Activity Score (PASDAS). Cross-sectional baseline data from British Society for Rheumatology PsA register (BSR-PsA) and GRAPPA Composite Exercise (GRACE) dataset was included. The body surface area score (BSA) Dermatology Life Quality Index (DLQI) were used assess disease activity. BSA categorized as none (0%), mild (<3%), moderate (3-10%), severe (>10%) involvement. DLQI no (0-1), small (2-5), (6-10),...
We investigated the effect of disease activity-guided dose optimization (DAGDO) TNF inhibitor (TNFi) on activity and TNFi in PsA axial spondyloarthritis (axSpA) patients with low (LDA).A retrospective cohort study was conducted axSpA doing well eligible for DAGDO. Three different treatment periods were defined: (i) full continuation period, (ii) DAGDO (iii) period stable after A mixed-model analysis used to estimate mean Disease Activity Score 28-joint count CRP (DAS28-CRP) Bath Ankylosing...
Psoriasis (Pso) is a chronic inflammatory skin disease, and up to 30% of Pso patients develop psoriatic arthritis (PsA), which can lead irreversible joint damage. Early detection PsA in crucial for timely treatment but difficult dermatologists implement. We, therefore, aimed find disease-specific immune profiles, discriminating from patients, possibly facilitating the correct identification need referral rheumatology clinic. The phenotypes peripheral blood cells consecutive were analyzed,...
Abstract Background Tumour necrosis factor inhibitors (TNFi) are effective in the treatment of patients with spondyloarthritis (SpA), including psoriatic arthritis (PsA) and axial (axSpA). However, these drugs come some disadvantages such as adverse events, practical burden for high costs. Dose optimisation TNFi after have reached low disease activity (LDA) has been shown feasible safe rheumatoid (RA). data on dose PsA axSpA scarce, especially pragmatic, randomised strategy studies. Methods...
Abstract Objectives We aimed to investigate the disease activity and overall burden of (subgroups of) patients with PsA using Psoriatic Arthritis Disease Activity Score (PASDAS) in an already tightly monitored cohort. Methods This is a cross-sectional study evaluating data from first visit 855 after implementation PASDAS our cohort [e.g. DAS 28 (DAS28) was provided as anchor]. Differences clinical outcomes between subgroups established cut-offs for status [i.e. very low (VLDA), (LDA),...
Patients with psoriasis are at risk of developing psoriatic arthritis, which can lead to irreversible joint damage. However, a proportion patients and concomitant arthritis remain undiscovered in practice. The aims this study were: prospectively determine prevalence, characteristics, disease burden population; the prevalence characteristics active who were not under rheumatological care. screened by rheumatologist dermatology outpatient clinic for arthritis. suspected seeing referred...
The aim of the study was to determine Minimal Important Change (MIC) values and Meaningful (MCV) for Psoriatic Arthritis Disease Activity Score (PASDAS) Standard Error Measurement (s.e.m.) PASDAS.The routine practice data 544 patients with PsA available analysis. An anchor-based method using linear regression analyses used MICs MCVs PASDAS. With this method, we compared changes in PASDAS score an external reference (anchor). anchor question inquired whether patient's well-being had changed...
Abstract Background Both methotrexate (MTX) and leflunomide (LEF) are registered regularly prescribed as first-line treatments for the use in patients with psoriatic arthritis (PsA) they occasionally used combination. However, evidence about their individual, especially combined efficacy, PsA is lacking. The aim of this study to compare effectiveness safety MTX LEF combination therapy monotherapy PsA. Methods COMPLETE-PsA a randomized, placebo-controlled, double-blind clinical trial....
Two years after its inception, Young Group for Research and Assessment of Psoriasis Psoriatic Arthritis (Y-GRAPPA) has established itself as a productive network junior investigators clinicians. The group’s achievements in the last year include updating educational GRAPPA slide library, “Bring Derm” campaign to expand community more dermatologists, publication multiple “Do Not Miss” newsletters covering highlights on PsDs from major international conferences (American Academy Dermatology...
To assess sex differences in disease activity parameters and health-related quality of life PsA, to whether determinants associated with not reaching treatment target differed between men women.Routine practice data 855 PsA patients, who were all tightly monitored treated, was used. Sex including, but limited to, Disease Activity Score (PASDAS), skin/nail disease, SF-12 PCS/MCS, inflammatory back pain (IBP) assessed. Multivariate analyses used examine (PASDAS ≤ 3.2) women.Women had worse...
Young-GRAPPA (Y-GRAPPA) was introduced at the 2021 Group for Research and Assessment of Psoriasis Psoriatic Arthritis (GRAPPA) annual meeting. Here we present 1-year progress Y-GRAPPA future plans this enthusiastic group young clinicians early career researchers interested in psoriasis psoriatic arthritis.
Psoriatic arthritis can cause pain, disability, and permanent joint damage. This lead to impairments in work social participation. Little is known about the extent of these routine practice. With this study, we aim examine activity impairment (subgroups of) Dutch patients with psoriatic (PsA), determinants associated impairment.This an observational study using data collected from electronic health records PsA treated at Sint Maartenskliniek, Netherlands. Data were via Work Productivity...
<h3>Background</h3> Psoriatic arthritis (PsA) is a heterogeneous disease, with involvement of at least five health domains: peripheral joint enthesitis, dactylitis, axial involvement, and skin nail psoriasis. Because the heterogeneity assessment disease activity challenging. One many single or composite outcome measures that has been developed Arthritis Disease Activity Score (PASDAS). The PASDAS comprehensive measure takes (66/68 score), CRP, physician VAS score patient-reported outcomes...
Background One in three patients with psoriasis (Pso) will develop psoriatic arthritis (PsA). Active PsA can lead to disability and joint damage. Current screening methods are targeted at finding all a Pso population. However, inactive disease unlikely benefit from rheumatological referral. Objectives To tool for dermatologists identify high risk active their population, who would Methods This observational study consisted of patients, stratified 1:1:1 current therapy (topical, conventional...
Background: One in three patients with psoriasis (Pso) will develop psoriatic arthritis (PsA) (1). When untreated, this can lead to disability and irreversible joint damage (2). Current screening methods are mostly based on questionnaires. These lack specificity sensitivity (3,4). Thus, a significant portion of PsA remains undetected. Objectives: Our main objective is ascertain the prevalence cohort Pso patient, treated at dermatology outpatient clinic. Secondary, we wish make referral tool...
The Group for Research and Assessment of Psoriasis Psoriatic Arthritis (GRAPPA) held a trainee symposium at its 2020 virtual meeting. Dermatology rheumatology trainees presented their work on psoriasis psoriatic arthritis. This report briefly reviews the 5 oral presentations 25 posters event.
Patients with psoriasis are at risk of developing psoriatic arthritis, which can lead to joint damage. While screening questionnaires have been developed, their performance varies. The objective this study was develop a referral tool for dermatologists identify patients concomitant arthritis rheumatological referral. This used data from the DAPPER study, in were screened by rheumatologist presence arthritis. Multivariable regression analysis predictive variables arthritis: treatment history...
Background Conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs) are the cornerstone first-line treatment in psoriatic arthritis (PsA), although there is a paucity of evidence for effectiveness csDMARDs and especially their combination. Assessing efficacy safety combinations compared with csDMARD monotherapy has been prioritized on EULAR research agenda. We hypothesized that combining might be more effective than monotherapy. Objectives aimed to investigate whether...