A5022285837- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- T-cell and Retrovirus Studies
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Phytochemical compounds biological activities
- Microtubule and mitosis dynamics
- Cancer Mechanisms and Therapy
- Bacterial Genetics and Biotechnology
- NF-κB Signaling Pathways
- Signaling Pathways in Disease
- Animal Disease Management and Epidemiology
- Plant biochemistry and biosynthesis
- Vector-Borne Animal Diseases
- DNA Repair Mechanisms
- Cancer, Hypoxia, and Metabolism
- Bioactive Natural Diterpenoids Research
- Cytokine Signaling Pathways and Interactions
- Research in Cotton Cultivation
- Child and Adolescent Psychosocial and Emotional Development
- Histone Deacetylase Inhibitors Research
- Bariatric Surgery and Outcomes
- Silk-based biomaterials and applications
University of Utah
2022
Sanatorium Kilchberg
2020
Max Planck Institute for Biophysical Chemistry
2015-2017
Heidelberg University
2009-2016
German Cancer Research Center
2009-2016
University of Basel
2016
Ludwig-Maximilians-Universität München
2015
ETH Zurich
2008-2009
Coupling transcription and translation In bacteria, the of DNA into mRNA by RNA polymerase is coupled to that protein ribosome. How this coupling achieved has been unclear. Kohler et al. show ribosome from Escherichia coli can form a so-called expressome complex. Electron microscopy structural analysis, together with functional experiments, revealed details The could allow prevent transcriptional pausing, backtracking, termination. Science , issue p. 194
The wogonin-containing herb Scutellaria baicalensis has successfully been used for curing various diseases in traditional Chinese medicine. Wogonin shown to induce apoptosis different cancer cells and suppress growth of human xenografts vivo. However, its direct targets remain unknown. In this study, we demonstrate the first time that wogonin structurally related natural flavones, example, apigenin, chrysin luteolin, are inhibitors cyclin-dependent kinase 9 (CDK9) block phosphorylation...
Tumor initiation, progression and resistance to therapies are tightly associated with over-expression of anti-apoptotic proteins Bcl-2, Bcl-x(L), Bcl-w Mcl-1. ABT-263 (Navitoclax), an orally bio-available small-molecule mimetic the Bcl-2 homology domain 3, inhibits has shown anti-cancer effects mainly on lymphomas lymphocytic leukemia. Despite promising results obtained from clinical trials, use in patients is dose-limited due causing thrombocytopenia via inhibition Bcl-x(L) platelets....
Hodgkin/Reed-Sternberg lymphoma (HL) is a clonal B-cell-related malignancy. Although many patients with HL can be cured by the current regimen of high-dose multi-agent chemotherapy, treatment causes high risks later pathologies including secondary malignancies. This fact highlights demand to develop rational for HL. Survival and growth cells are largely dependent on their microenvironment. In this study, using cell lines L1236 KM-H2 as model systems, we investigated role IL-4/IL-13 signaling...
The early growth response gene product Egr-1 has been shown to have great impact on growth, proliferation, and differentiation in a wide variety of cells, including T cells. In this study, we show that is rapidly induced upon cell stimulation expressed predominantly helper type 2 (Th2) compared with 1 (Th1) We further investigate the role regulation Th2 cytokine interleukin-4 (IL-4) expression. IL-4 key regulates humoral immunity also causes allergic inflammation. Regulation transcription...
Abstract The human T-lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL). HTLV-1 Tax has been shown to have a prosurvival role in infected T cells by enhancing expression Bcl-2 family antiapoptotic proteins. In this study, we show that proapoptotic BH3-only proteins Bim (Bcl-2-interacting mediator cell death) and Bid (BH3-interacting domain death agonist) diminished HTLV-1-infected leukemic cells. Using Tax-inducible system transient overexpression...
Natural compounds are an important source for drug development. With increasing cancer rate worldwide there is urgent quest new anti-cancer drugs. In this study, we show that a group of dolabrane-type diterpenes, collectively named tagalsins, isolated from the Chinese mangrove genus Ceriops has potent cytotoxicity on panel hematologic cells. Investigation molecular mechanisms by which tagalsins kill malignant cells revealed it induces ROS-mediated damage DNA. This event leads to apoptosis...
Targeting the cancer cell cycle machinery is an important strategy for treatment. Cdc25A essential regulator of progression and checkpoint response. Over-expression occurs often in human cancers. In this study, we show that Rocaglamide-A (Roc-A), a natural anticancer compound isolated from medicinal plant Aglaia, induces rapid phosphorylation its subsequent degradation and, thereby, blocks tumor cells at G1-S phase. Roc-A has previously been shown to inhibit proliferation by blocking protein...
// Michael S. Becker 1 , Paul M. Müller 2 Jörg Bajorat Anne Schroeder Marco Giaisi Ehsan Amin 3 Mohammad R. Ahmadian Oliver Rocks Rebecca Köhler Peter H. Krammer Min Li-Weber Tumorimmunology Program (D030), German Cancer Research Center (DKFZ), INF-280, Heidelberg, Germany Max Delbrück for Molecular Medicine Berlin-Buch, Berlin, Institute of Biochemistry and Biology II, Medical Faculty The Heinrich-Heine University, Düsseldorf, Correspondence to: Li-Weber, email:...
Although most of the patients with Hodgkin's lymphoma (HL) can be cured by current regimen high-dose multiagent chemotherapy, treatment causes high risks later toxicities including secondary malignancies. Therefore, new rational strategies are needed for HL treatment. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent due to its tumor selectivity and lack toxicity normal cells. Unfortunately, many cancers remain resistant TRAIL HL. characterized...
The role of Wilms' tumor suppressor 1 (WT1) in leukemogenesis has been investigated mostly acute (AML) and chronic (CML) myeloid leukemias. So far, its oncogenic controversially discussed because both overexpression inactivating mutations are found. A recent study on primary samples from patients with T-cell leukemia (T-ALL) revealed that most them do not express WT1 proteins although they mRNA. In our study, we WT-1 expression ten T-ALL cell lines established leukemia/lymphoma patients. We...
Over‐expression of Bcl‐2, Bcl‐x L and Bcl‐w is frequently associated with cancer resistance to chemotherapy. Navitoclax (ABT‐263), an orally bio‐available small‐molecule mimetic the Bcl‐2 homology domain 3, specifically inhibits Bcl‐w. Despite promising results obtained from clinical trials, use in patients dose‐limited due induction death platelets via inhibition subsequent thrombocytopenia. This side effect limits low doses very sensitive tumors. In this study, we show that...
Introduction/Aim: We investigate the yet unknown function of neolacto-glycosphingolipids GSLs (P1 and nLc4) on drug sensitivity response to hypoxia, two major obstacles in cancer management. used parental IGROV1 ovarian cells our previously generated knockout subline disrupted B3GNT5 gene (B3GNT5-ko). is key enzyme P1 nLc4 biosynthesis. are located cell membranes considered be critically implicated pathogenesis various diseases cancer.