A5085074053- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Analytical Chemistry and Chromatography
- Asymmetric Hydrogenation and Catalysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Organophosphorus compounds synthesis
- Molecular spectroscopy and chirality
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Reactions
- Synthesis and biological activity
- Sulfur-Based Synthesis Techniques
- Synthetic Organic Chemistry Methods
- Multicomponent Synthesis of Heterocycles
- Synthesis of heterocyclic compounds
- Inorganic and Organometallic Chemistry
- Mass Spectrometry Techniques and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Advanced Synthetic Organic Chemistry
- Crystallography and molecular interactions
- Carbohydrate Chemistry and Synthesis
- Click Chemistry and Applications
- Chemical Reaction Mechanisms
- Synthesis of β-Lactam Compounds
Carl von Ossietzky Universität Oldenburg
2013-2024
Kharazmi University
2016
Kiel University
2012
Klinikum Hanau
1979-2006
VOCO (Germany)
2006
Bauhaus-Universität Weimar
2005
Indian Institute of Technology Roorkee
2003
KU Leuven
2000-2002
Universitat Jaume I
2002
École Nationale Supérieure de Chimie de Lille
1998-2000
The catalytic and enantioselective hydrophosphonylation of cyclic imines is described for the first time. In addition, we have uncovered a new highly efficient asymmetric approach to α-amino phosphonates using thiazolines as imine model component. desired pharmaceutically interesting 5a−e could be synthesized by heterobimetallic (R)-LnPB-catalyzed (Ln = lanthanoid metal, P potassium, B (R)=binaphthol) CN double bond with up 98% enantiomeric excess chemical yield. Using other types...
Abstract Since the stereoisomers of molecules with one or more asymmetric centers often exhibit different biological activities ( e.g. thalidomide, pheromones), stereoselective synthesis as a method preparative chemistry is rapidly attaining importance. Of numerous drugs prepared by total that contain at least center, only about 20% have so far been used in sterically pure form. Amino acids constitute greatest “chiral pool” compounds whose enantiomers can be obtained commercially large...
Abstract The syntheses of optically active compounds (whether pharmaceutical or synthetic importance, as promising candidates chiral ligands and auxiliaries in asymmetric syntheses) result the formation a mixture products with one enantiomer predominating. Usually, practice is to use standard open‐column chromatography for first purification step an enantioselective synthesis; workup reaction product by crystallization achiral would mask real efficiency methodology, since enantiomeric ratio...
The catalytic and enantioselective hydrophosphonylation of cyclic imines using phosphites is described for the first time. In contrast to application acyclic phosphites, significant improvements are presented arising from concept improved rigidity by utilization in lanthanoid BINOL complex catalyzed 3-thiazolines. Cyclic shown provide certain within cycle. Influence parameters such as concentration catalyst phosphite on catalysis examined well effects substituents starting material....
Racemic amino acids can be resolved straightforwardly and rapidly using thinlayer chromatography. Decisive in this respect is that the TLC plates are impregnated with chiral selector 1. The method also enables determination of enantiomeric purity acids.
Eine einfache und schnelle Trennung racemischer Aminosäuren ist dünnschichtchromatographisch möglich. Entscheidend die Imprägnierung der DC-Platten mit dem chiralen Selektor 1. Mit dieser Methode läßt sich auch Enantiomerenreinheit von ermitteln.
Liquid crystals having favorable transition temperatures have been discovered in the selenol esters of type (1). Their properties should be further enhanced by variation R1 and R2.
Polymeric monoliths 10 containing an amino alcohol moiety derived from industrial waste material represent one of the best ligands for enantioselective catalytic addition ZnEt2 to benzaldehyde (99% ee), being recoverable and usable under flow conditions.
Introduction The objective and significance of the topic is to draw attention toward regulatory aspects (and pharmacopoeias) for bioequivalence investigation, perception generic pharmaceuticals, especially their stereoselective evaluation understanding performance racemic products available in market.
In this paper, we evaluate and contrast two types of fuzzy classifiers for credit scoring. The first classifier uses evolutionary optimization boosting learning classification rules. second is a neural network that employs variant the classic backpropagation algorithm. experiments are carried out on real life scoring data set. It shown that, case at hand, boosted genetic performs better than both neurofuzzy well-known C4.5(rules) decision tree(rules) induction However, performance offset by...
Abstract Enantiocontrolled reduction of prochiral ketones with borane in the presence homochiral amino alcohols 1—3 as enantioselective catalysts afforded corresponding secondary moderate to high (69 >99 %) optical yields.
Abstract Just 20 % of chiral synthetic drugs are used as pure stereoisomers 1) , although it is known from numerous examples that optical isomers may have quite different biological effects 2) . Therefore the enantiomeric purity an important probe for monitoring quality drugs. The availability reliable analytical techniques correct determination compositions therefore becoming increasingly important. Such a method should allow us to deal successfully with small impurities.
Economical raw materials such as ammonia and acetone are the educts of a new total synthesis racemic cysteine (2), which is obtained in good yields few steps via (1) its HCN adduce.
Depending upon the structure of starting compounds, seleno-photo-Fries products or cyclization (phenenthrenequinone selenoxanthone) are obtained in novel photoreactions from areneselenol esters aromatic carboxylic acids.