A5021703800- Photosynthetic Processes and Mechanisms
- Enzyme Production and Characterization
- Protein Interaction Studies and Fluorescence Analysis
- Alzheimer's disease research and treatments
- Enzyme Structure and Function
- Plant Stress Responses and Tolerance
- Neuroscience and Neuropharmacology Research
- Enzyme-mediated dye degradation
- Neuroinflammation and Neurodegeneration Mechanisms
- Plant and animal studies
- Metabolism and Genetic Disorders
- Drug Solubulity and Delivery Systems
- Climate variability and models
- Mitochondrial Function and Pathology
- Mosquito-borne diseases and control
- Parkinson's Disease Mechanisms and Treatments
- Surfactants and Colloidal Systems
- Light effects on plants
- CRISPR and Genetic Engineering
- Meteorological Phenomena and Simulations
- Viral Infections and Vectors
- Plant nutrient uptake and metabolism
- Biochemical and Structural Characterization
- Hydrology and Drought Analysis
- Natural Antidiabetic Agents Studies
North Eastern Regional Institute of Science and Technology
2025
Amity University
2022-2025
Rockefeller University
2022-2024
Institute of Technology Management
2024
Columbia University
2024
Columbia University Irving Medical Center
2024
Invertis University
2024
Rainbow Children's Hospital
2023
Central Forensic Science Laboratory
2023
Krishi Vigyan Kendra, Ghatkhed Amravati
2022-2023
Phosphorus (P) is an essential macronutrient, and P deficiency limits plant productivity. Recent work showed that affects electron transport to photosystem I (PSI), but the underlying mechanisms are unknown. Here, we present a comprehensive biological model describing how disrupts photosynthetic machinery chain through series of sequential events in barley (Hordeum vulgare). reduces orthophosphate concentration chloroplast stroma levels inhibit ATP synthase activity. Consequently, protons...
During vertebrate organogenesis, increases in morphological complexity are tightly coupled to morphogen expression. In this work, we studied how morphogens influence self-organizing processes at the collective or “supra”-cellular scale avian skin. We made physical measurements across length scales, which revealed morphogen-enabled material property differences that were amplified supracellular scales comparison cellular scales. At scale, found fibroblast growth factor (FGF) promoted...
Abstract Insect societies are tightly integrated, complex biological systems in which group-level properties arise from the interactions between individuals 1–4 . However, these have not been studied systematically and therefore remain incompletely known. Here, using a reverse engineering approach, we reveal that unlike solitary insects, ant pupae extrude secretion derived moulting fluid is rich nutrients, hormones neuroactive substances. This elicits parental care behaviour rapidly removed...
The field of oral drug delivery has witnessed significant advancements, with a focus on developing innovative formulations to address challenges associated traditional dosage forms, especially for patients difficulties in swallowing. Fast Dissolving Tablets (FDTs) have emerged as promising class tablets designed rapidly disintegrate or dissolve saliva, providing convenient and patient-friendly alternative various populations. This article explores the unique properties, advantages, potential...
The thylakoid membrane system of higher plant chloroplasts consists interconnected subdomains appressed and nonappressed bilayers, known as grana stroma lamellae, respectively. CURVATURE THYLAKOID1 (CURT1) protein complexes mediate the shape stacks in a dosage-dependent manner facilitate curvature at margins, interface between lamellae. Although are highly conserved among land plants, functional relevance stacking remains unclear. Here, we show that inhibiting CURT1-mediated alteration...
Proteinaceous brain inclusions, neuroinflammation, and vascular dysfunction are common pathologies in Alzheimer’s disease (AD). Vascular deficits include a compromised blood–brain barrier, which can lead to extravasation of blood proteins like fibrinogen into the brain. Fibrinogen’s interaction with amyloid-beta (Aβ) peptide is known worsen thrombotic cerebrovascular pathways AD. Lecanemab, an FDA-approved antibody therapy for AD, clears Aβ plaque from slows cognitive decline. Here, we show...
Heparin is one of the members glycosaminoglycan (GAG) family, which has been associated with protein aggregation diseases including Alzheimer's disease, Parkinson's and prion diseases. Here, we investigate heparin-induced bovine serum albumin (BSA) using different spectroscopic techniques [absorption, 8-anilino-1-naphthalene sulfonic acid (ANS) thioflavin T (ThT) fluorescence binding, far- near-UV circular dichroism]. Kinetic measurements revealed that heparin involved in significant...
The crude latex of Ficus religiosa is decolorized by activated charcoal. Decolorization follows the Freundlich and Langmuir equations. A serine protease, named religiosin, has been purified to homogeneity from using anion exchange chromatography. Religiosin a glycoprotein with molecular mass 43.4 kDa MALDI-TOF. an acidic protein pI value 3.8 acts optimally at pH 8.0−8.5 temperature 50 °C. proteolytic activity religiosin strongly inhibited PMSF chymostatin indicating that enzyme protease....
Abstract In variable light environments, plants adjust use in photosynthetic electron transport and photoprotective dissipation the thylakoid membrane. this respect, roles of K + /H antiporter KEA3, Cl − channel/transporter CLCe voltage-dependent channel VCCN1 have been unraveled Arabidopsis thaliana . Here we report that they independently photosynthesis on basis analyses using single higher order loss-of-function mutants. short experiments response transition from dark to low light, reveal...
nHAP (mainly composed of Ca and P, but also spiked with Sr, V Ce tracers) initially adheres to the surface roots, before penetrating dissolving in plant.
Significance Chloroplast biogenesis is a fundamental process occurring during seedling ontogenesis and leading to plant autotrophy. Which membrane components sterically organize the light-triggered transition of etioplast prolamellar bodies (PLBs) into chloroplast thylakoids, thus mediate cubic–lamellar transformation, poorly understood. Here, we used combined two- three-dimensional electron microscopy, spectroscopy, biochemical methods determine role CURT1 proteins in formation cubic...
A serine protease was purified to homogeneity from the latex of medicinal plant Ficus benghalensis by a single step procedure using anion exchange chromatography. The enzyme, named benghalensin, has molecular mass 47 kDa (MALDI-TOF and SDS-PAGE). protein is glycoprotein, enzymatic activity solely inhibited PMSF chymostatin, indicating that enzyme belongs class. isoelectric point pH 4.4 with optimum temperature 8.0 55 degrees C respectively. extinction coefficient (epsilon(1%)(280)) 29.25,...
Abstract The binding affinity of a drug with carrier proteins plays major role in the distribution and administration within body. Tizanidine (TND) is muscle relaxant having antispasmodic antispastic effects. Herein, we have studied effect tizanidine on serum albumins by spectroscopic techniques, such as absorption analysis, steady, state fluorescence, synchronous circular dichroism, molecular docking. constant number sites TND were determined means fluorescence data. thermodynamic...
Background: Peroxidases are heme-containing oxidoreductase enzymes that have the potential to oxidise a wide range of organic and inorganic substances in presence hydrogen peroxide. Peroxidase has capability bioremediate various toxic carcinogenic phenolic nonphenolic compounds, pollutants, polychlorinated hydrocarbons. Different types chemicals change rate enzyme-catalysed reactions binding with enzyme or enzyme-substrate complex. Enzyme activators increase activity, while inhibitors...
The commonly used muscle relaxant chlorzoxazone (CZZ) is basic in nature and binds to acidic alpha-1-glycoprotein, affecting the levels of albumins as well lipoproteins body. This can impact biological half-life drug interfere with its therapeutic requirements. Herein, we have shown CZZ on structure bovine serum albumin (BSA), a transport protein, through various spectroscopic techniques like UV-vis absorption, steady state emission, synchronous fluorescence, also circular dichroism (CD)....
Abstract Female mosquitoes typically mate once in a lifetime 1–3 , making this singular mating decision critically important for the female. Yet, mosquito has been historically viewed as male-guided, with female exerting little control 4–6 . To understand contradiction, we investigated initiation of successful mosquitoes. Here show that females two invasive species, yellow fever ( Aedes aegypti ) and Asian tiger albopictus ), actively gate through previously undescribed behavior genital tip...