A5101497013- Attention Deficit Hyperactivity Disorder
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Speech and dialogue systems
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Bipolar Disorder and Treatment
- Liver Disease Diagnosis and Treatment
- Pharmaceutical Economics and Policy
- Natural Language Processing Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatic and Hepatic Oncology Research
- Topic Modeling
- Colorectal Cancer Screening and Detection
- Neurotransmitter Receptor Influence on Behavior
- Alcohol Consumption and Health Effects
- Speech Recognition and Synthesis
- Intracerebral and Subarachnoid Hemorrhage Research
- Pharmaceutical studies and practices
- Gastric Cancer Management and Outcomes
- Microscopic Colitis
- Inflammatory Bowel Disease
- Child and Adolescent Psychosocial and Emotional Development
- Neurosurgical Procedures and Complications
- Eosinophilic Esophagitis
Carnegie Mellon University
2022-2025
Chinese University of Hong Kong
2012-2024
Prince of Wales Hospital
2010-2024
Shanghai Institute of Organic Chemistry
2024
Chinese Academy of Sciences
2010-2024
Thomas Jefferson University Hospital
2021-2023
London Health Sciences Centre
2019-2023
Thomas Jefferson University
2021-2022
Sidney Kimmel Cancer Center
2022
Takeda (United States)
2016-2021
Inflammasomes are cytosolic multiprotein complexes that initiate host defense against bacterial pathogens by activating caspase-1-dependent cytokine secretion and cell death. In mice, specific nucleotide-binding domain, leucine-rich repeat-containing family, apoptosis inhibitory proteins (NAIPs) activate the CARD domain-containing protein 4 (NLRC4) inflammasome upon sensing components of type III system (T3SS) flagellar apparatus. NAIP1 recognizes T3SS needle protein, NAIP2 inner rod NAIP5...
OBEJCTIVE: To compare left ventricular (LV) systolic performance and contractility in patients with heart failure normal ejection fraction (HFNEF), compared reduced (HFREF) healthy subjects using newer echocardiographic techniques.A case-control trial.University teaching hospital (tertiary referral centre).Sixty control (53 ± 10 years), 112 HFNEF (74 12 years) 175 HFREF (67 13 years).All underwent standard two-dimensional, Doppler speckle-tracking echocardiography.Effective arterial (Ea) LV...
Abstract Aims: The outcome of in‐hospital resuscitation following cardiac arrest depends on many factors related to the patient, environment and extent efforts. aim present study was determine predictors successful survival hospital discharge assess functional outcomes survivors (cerebral performance scores). Methods: Medical records adult patients sustaining between June 2001 January 2003 were reviewed. Successful defined as return spontaneous circulation at completion resuscitative...
Psychostimulants are considered first-line pharmacotherapy for youth with attention-deficit/hyperactivity disorder (ADHD), but questions remain regarding the comparative efficacy of amphetamine- and methylphenidate-based agents. Our objective was to describe two acute randomized, double-blind, placebo-controlled, head-to-head studies lisdexamfetamine dimesylate (LDX) osmotic-release oral system methylphenidate (OROS-MPH) in adolescents ADHD. Adolescents (13–17 years) diagnosed ADHD according...
Attention-deficit/hyperactivity disorder (ADHD) is increasingly recognized as a persistent requiring long-term management. Our objective was to evaluate the 2-year safety and efficacy of lisdexamfetamine dimesylate (LDX) in children adolescents with ADHD. Participants (aged 6–17 years) ADHD received open-label, dose-optimized LDX 30, 50, or 70 mg/day for 104 weeks. Safety monitoring included treatment-emergent adverse events (TEAEs), vital signs, electrocardiography, growth. The TEAEs...
Lin Yutang, as a renowned Chinese and foreign writer, translator educator, has crossed many cultural fields in his life, made important contributions to the exchange between China West cause of education with unique literary talent humanistic educational philosophy. The turbulence times him have lot experiences, from family private school southern Fujian long road several western countries, continuous change geography space time come into contact different forms also shaped view education....
Abstract INTRODUCTION Fungal organisms have been implicated in disease activity patients with inflammatory bowel (IBD). The effect of antifungal therapy on IBD remains unclear. purpose our study was to (1) report indications for fluconazole use and (2) examine whether affected at follow-up. METHODS We performed a retrospective review institution who took between January 2012 December 2023. Patients were remission baseline matched control group did not take (Cohort A). had active B) [Fig 1]....
The aim of this study was to determine the incidence and clinical pathological features gastrointestinal stromal tumors within a nonselected, well-defined Canadian Health Region. A population-based cohort all adult patients diagnosed with conducted in Calgary Region from April 2000 March 2004. All charts specimens were reviewed for clinical, histological, antigenic features. age-adjusted gender-adjusted annual rate 0.91/10 5 person-years. There trend increased routine use CD117. only...
Objective: Evaluate the efficacy and tolerability of triple-bead mixed amphetamine salts (MAS) in ADHD. Method: Adults with ADHD Rating Scale IV (ADHD-RS-IV) total scores ≥32 were randomized to 6 weeks MAS (25, 50, or 75 mg) placebo. The primary endpoint was ADHD-RS-IV score change from baseline at end study (EOS). Results: Least squares mean (95% confidence interval [CI]) treatment differences for changes EOS significantly favored (all doses combined: −10.6 [−13.2, −8.0]; p < .0001);...
The objective of this randomized, double-blind, placebo-controlled study was to evaluate the efficacy and safety SHP465 mixed amphetamine salts (MAS) in adults with attention-deficit/hyperactivity disorder (ADHD). Eligible [aged 18–55 years; meeting Diagnostic Statistical Manual Mental Disorders, Fifth Edition ADHD criteria; baseline Rating Scale Adult Prompts (ADHD-RS-AP) total scores ≥28] were randomized 1:1:1 placebo or forced-dose MAS (12.5 37.5 mg/day) for 4 weeks. ADHD-RS-AP score...
Pancreatitis is a condition that causes inflammation in the pancreas, an organ located behind stomach. This often presents as neuropathic, inflammatory, and/or visceral pain. Acute pancreatitis typically characterized by sudden and severe abdominal pain, upper right part of abdomen. The pain from can be caused different mechanisms, such abnormal activation pancreatic zymogens or NF-κB mediated pancreas. treatment depends on its type, severity, underlying cause. Hospitalization medications...
Stimulant medications for the treatment of attention-deficit/hyperactivity disorder have a history safe and effective use; however, concerns exist that they may adversely affect growth trajectories in children adolescents. The objective this study was to evaluate longer-term effects lisdexamfetamine dimesylate on weight, height, body mass index pubertal development adolescents with disorder. Children aged 6–17 years took open-label (30, 50 or 70 mg/day) 2-year safety efficacy study. Safety...
Rofecoxib is a member of the coxib family nonsteroidal anti-inflammatory drugs that selectively inhibit cyclooxygenase-2. Although coxibs are generally well-tolerated, rofecoxib was recently withdrawn from market due to concerns regarding cardiovascular safety. Rare cases hepatic injury attributable have been reported. In present study, two additional severe hepatotoxicity described in patients with cholestatic symptoms and abnormal liver biochemistry, shortly following initiation for...