A5037097714- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Infective Endocarditis Diagnosis and Management
- Genetic Associations and Epidemiology
- Infectious Diseases and Tuberculosis
- Rheumatoid Arthritis Research and Therapies
- Surgical site infection prevention
- Osteoarthritis Treatment and Mechanisms
- Systemic Lupus Erythematosus Research
- Nerve Injury and Rehabilitation
- Lymphatic System and Diseases
- Bone health and treatments
- Lung Cancer Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Respiratory and Cough-Related Research
- Antimicrobial Resistance in Staphylococcus
- Breast Cancer Treatment Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Ovarian cancer diagnosis and treatment
- Advanced biosensing and bioanalysis techniques
- Sarcoidosis and Beryllium Toxicity Research
- Biosensors and Analytical Detection
- Glaucoma and retinal disorders
- Bone and Joint Diseases
Fuzhou Maternity and Child Health Care Hospital
2024-2025
Fujian Medical University
2019-2025
First Affiliated Hospital of Fujian Medical University
2019-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2011-2024
Songshan Lake Materials Laboratory
2024
Guangdong Medical College
2016-2024
Army Medical University
2015-2024
Chongqing Medical University
2024
Second Affiliated Hospital of Chongqing Medical University
2024
Dalian Medical University
2024
Background: Rheumatoid arthritis (RA) is a key health issue worldwide. Due to early identification and effective treatment strategies, the disease pattern of RA has also changed. However, most comprehensive up-to-date information about burden its trends in subsequent years lacking. Objective: this study aimed report global by sex, age, region, forecast for 2030. Method: Publicly available data from Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2019 were used study. The...
In peripheral nerve injuries (PNIs) in which proximal axons do not regenerate quickly enough, significant chronic degeneration of Schwann cells (SCs) can occur at the distal stump injured and obstruct regeneration. Cell transplantation delay SCs, but transplanted fail to generate voluntary electrical impulses without downstream signal stimulation from central nervous system. this study, we combined cell transfer strategies investigate whether embryonic spinal cord could benefit...
This study aims to report the most up-to-date information about global disease burden of glaucoma from 1990 2019 and forecast trends in next few years. Publicly available data Global Burden Diseases, Injuries, Risk Factors Study (GBD) were used this study. The prevalence disability-adjusted life years (DALYs) reported. Finally, following predicted by Bayesian age-period-cohort (BAPC) models. We showed that, globally, number prevalent cases was 3,881,624 [95% uncertainty interval (UI):...
Abstract Accurate identification and localization of multiple abnormalities are crucial steps in the interpretation chest X-rays (CXRs); however, lack a large CXR dataset with bounding boxes severely constrains accurate research based on deep learning. We created named CXR-AL14, containing 165,988 CXRs 253,844 boxes. On basis this dataset, deep-learning-based framework was developed to identify localize 14 common calculate cardiothoracic ratio (CTR) simultaneously. The mean average precision...
ObjectivesThe purpose of this study was to explore the role mNGS in diagnosis PJI by detecting presence bacteria periprosthetic tissues.MethodsPatients who were suspected and underwent surgery our center enrolled. Microbial culture performed on tissues collected intraoperatively. Patient age, body mass index (BMI), laboratory tests, microbial results recorded. The diagnostic performance compared.ResultsA total 44 patients included. sensitivity, specificity, positive predictive value (PPV),...
Background The relationship between osteoarthritis (OA) and senile central nervous system dysfunctions (CNSDs), including Parkinson’s disease (PD), Alzheimer’s (AD), ischemic stroke (IS) has gradually attracted attention. At present, the causal OA CNSD remains unclear. aim of this study was to assess effects using Mendelian randomization (MR). Methods Genome-wide association summary data for were obtained. Single-nucleotide polymorphisms (SNPs) selected as instrumental variables (IVs),...
There is an urgent clinical need for appropriate method to shorten skin healing time. Among most factors related wound healing, M2 macrophages will be recruited the area and play a pivotal role in time-limiting factor, angiogenesis. The exploration of exosomes derived from angiogenesis promotion attractive research field. In this project, we found that (M2-EXO) promoted angiogenic ability HUVECs vitro . With series characteristic experiments, demonstrated M2-EXO inhibited PTEN expression by...
Background: Adiposity is closely related to osteoarthritis, but the causal effects of different types adiposity on osteoarthritis are indistinct. This study conducted a Mendelian Randomization (MR) analysis for general and abdominal knee (KOA) hip (HOA). Methods: The was assessed by body mass index (BMI), while evaluated with waist circumference (WC), (HC), waist-to-hip ratio (WHR). data used in this two-sample MR originated from genome-wide association studies (GWAS). Significant (p < 5...
Abstract MicroRNAs (miRNAs) are key regulators in various physiological and pathological processes via post‐transcriptional regulation of gene expression. The honey bee ( Apis mellifera ) is a model for highly social species, its complex behaviour can be interpreted theoretically as changes regulation, which miRNAs thought to involved. We used the SOLiD sequencing system identify repertoire by mixed small RNA library from different developmental stages. obtained total 36 796 459 raw...
ObjectivesPreoperative diagnosis is important for patients who need revision surgery due to PJI. Microbial culture plays an role in PJI diagnosis, but the sensitivity of cultures low when sample amount limited or a patient treated with antibiotics before collection. In this study, metagenomic next-generation sequencing (mNGS) was used detect bacteria preoperative puncture synovial fluid samples from suspected PJI, and intraoperative results were compared estimate its diagnostic...
This study aimed to evaluate calprotectin in synovial fluid for diagnosing chronic prosthetic joint infection (PJI) . A total of 63 patients who were suspected PJI enrolled. The was tested by an enzyme-linked immunosorbent assay (ELISA). Laboratory test data, such as ESR, CRP, white blood cells (SF-WBCs), and polymorphonuclear (SF-PMNs), documented. Chi-squared tests used compare the sensitivity specificity laboratory tests. area under curve (AUC) receiver operating characteristic (ROC)...
This study aimed to explore the diagnostic value of synovial fluid neutrophil extracellular traps (SF-NETs) in periprosthetic joint infection (PJI) diagnosis, and compare it with that microbial culture, serum ESR CRP, white blood cell (WBC) count, polymorphonuclear percentage (PMN%).In a single health centre, patients suspected PJI were enrolled from January 2013 December 2021. The inclusion criteria were: 1) who have PJI; 2) complete medical records; 3) whom sufficient was obtained for...
Aims Microbiological culture is a key element in the diagnosis of periprosthetic joint infection (PJI). However, cultures tissue do not have optimal sensitivity. One main reasons for this that microorganisms are released from tissues, either due to biofilm formation or intracellular persistence. This study aimed optimize pretreatment methods order improve detection microorganisms. Methods From December 2017 September 2019, patients undergoing revision arthroplasty single centre PJI and...
This study aimed to explore the role of small colony variants (SCVs) Staphylococcus aureus in intraosseous invasion and colonization patients with periprosthetic joint infection (PJI).A PJI diagnosis was made according MusculoSkeletal Infection Society (MSIS) for PJI. Bone tissue samples were collected intraoperatively intracellular detected. Transcriptomics analyzed verified by polymerase chain reaction (PCR).SCVs can be isolated from chronic PJIs intraoperatively. Transmission electron...
Abstract Background The interaction between the nervous system and immune can affect outcome of a bacterial infection. Staphylococcus aureus skin infection is common infectious disease, elucidating relationship may help to improve treatment strategies. Results In this study, we found that local release calcitonin gene-related peptide (CGRP) increased during S. infection, could promote CGRP from transient receptor potential cation channel subfamily V member 1 (TRPV1 + ) neurons in vitro....
Aims Metagenomic next-generation sequencing (mNGS) is useful in the diagnosis of infectious disease. However, while it highly sensitive at identifying bacteria, does not provide information on sensitivity organisms to antibiotics. The purpose this study was determine whether results mNGS can be used guide optimization culture methods improve from intraoperative samples. Methods Between July 2014 and October 2019, patients with suspected joint infection (JI) whom synovial fluid (SF) obtained...
This study aimed to analyze the pathogenic bacteria spectrum in invasive and primary osteoarticular infection (IOI POI) compare pathogen detection rate of metagenomic next-generation sequencing (mNGS) microbial culture IOI POI.The suspected POI cases from 2014-2021 were included. The diagnosis or was made by at least two orthopedic surgeons, infectious diseases specialists, one senior microbiologist. Demographic characteristics, results, so on recorded. analyzed, ability mNGS compared.There...
Magnesium (Mg)-based conduits have gained more attention in repairing peripheral nerve defects. However, they are limited due to poor corrosion resistance and rapid degradation rate. To tackle this issue, glial cell line-derived neurotrophic factor (GDNF)- Gelatin methacryloyl (Gel)/hydroxylapatite (HA)-Mg conduit was developed implanted sciatic defect model Sprague-Dawley (SD) rats. The functional index measurement showed that the GDNF-Gel/HA-Mg effectively promoted recovery of function....
Orthopedic implants with high elastic modulus often suffer from poor osseointegration due to stress shielding, a phenomenon that suppresses the expression of intracellular mechanotransduction molecules (IMM) such as focal adhesion kinase (FAK). We find reduced FAK under shielding is also mediated by decreased calcitonin gene-related peptide (CGRP) released Piezo2+ mechanosensitive nerves surrounding implant. To activate these minimally invasively, we develop fully implantable, wirelessly...