A5085339990- Gut microbiota and health
- Probiotics and Fermented Foods
- Muscle metabolism and nutrition
- Clostridium difficile and Clostridium perfringens research
- Epigenetics and DNA Methylation
- Microbial Metabolites in Food Biotechnology
- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Oral microbiology and periodontitis research
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Clinical Nutrition and Gastroenterology
Hainan University
2022-2025
Probiotics have shown good efficacy in the prevention of ulcerative colitis (UC), but specific mechanism remains unclear. Therefore, shotgun metagenomic and transcriptome analyses were performed to explore preventive effect a potential probiotic Lactobacillus plantarum HNU082 (Lp082) on UC its mechanism. The results showed that Lp082 intervention ameliorated dextran sulfate sodium (DSS)-induced mice, which was manifested increase body weight, water intake, food colon length decrease DAI...
The potential mechanism of L. fermentum HNU312 in improving metabolic disorders and inflammation induced by a high-fat diet.
Sarcopenia significantly diminishes quality of life and increases mortality risk in older adults. While the connection between gut microbiome muscle health is recognized, underlying mechanisms are poorly understood. In this study, shotgun metagenomics revealed that Bifidobacterium adolescentis notably depleted individuals with sarcopenia, correlating reduced mass function. This finding was validated aged mice. Metabolomics analysis identified nicotinic acid as a key metabolite produced by B....
Probiotics encounter colonization resistance from native gut microbiomes, affecting their effectiveness. Genetic engineering of probiotics lacks universal applicability, as microbiotas are highly individualized. Here, we employed probiotic Lactiplantibacillus plantarum HNU082 (Lp082) to test whether Lp082 gut-adapted mutants can resolve in a new environment. Relying on culture-based methods and metagenomics, two distinct evolutionary clades mice were observed, where one clade, which acquired...
Sarcopenia is a major health challenge due to an aging population. Probiotics may improve muscle function through gut-muscle axis, but their efficacy and mechanisms in treating sarcopenia remain unclear. This study investigated the impact of Bifidobacterium animalis subsp. lactis Probio-M8 (Probio-M8) on old mice patients. We analyzed 43 subjects, including gut microbiome, fecal metabolome, serum using multi-omics approach assess whether can by modulating microbial metabolites. significantly...
Lactiplantibacillus plantarum HNU082 (Lp082) exhibits a wide range of health-modulating effects. However, its limited ability to colonize the intestines has hindered long-term To enhance colonization capability Lp082, we conducted an intermittent intervention trial in mice and humans. After two interventions, Lp082 strain rapidly mutated after second intervention, with greater number mutations observed human gut. By analyzing abundance fluctuations gut microbiota, key microbial factors that...
The gut microbiome plays a critical role in human health and disease. Different dietary backgrounds play an important the uniqueness diversity of microbiota different individuals, which promotes heterogeneity disease phenotypes treatment responses. Here, we explored how diet affects composition function native model mice, based on shotgun metagenomic metabolomic, by analyzing C57B/6J mice backgrounds.