A5095939358- RNA modifications and cancer
- Metalloenzymes and iron-sulfur proteins
- Folate and B Vitamins Research
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Geriatric Care and Nursing Homes
- Biochemical and Molecular Research
- Palliative Care and End-of-Life Issues
- Healthcare Decision-Making and Restraints
Northwestern University
2024
Providing ethical, timely, and goal-concordant care for critical patients who are incapacitated with no evident advance directives or surrogates (INEADS) can pose challenges to nursing staff other team members may delay alter trajectories. In a nested case-control study, we aimed determine whether INEADS have different hospitalization timelines, consultative services, discharge dispositions relative matched control subjects. Data were obtained from the publicly accessible Medical Information...
<title>Abstract</title> <bold>Background:</bold> Molybdenum cofactor deficiency (MoCD) is a rare metabolic disorder caused by pathogenic variants in the highly conserved biosynthetic pathway of molybdenum (MoCo), resulting sulfite intoxication. MoCD may present clinically severe, rapidly fatal form marked intractable seizures after birth, hyperekplexia, microcephaly and cerebral atrophy, or later onset with more varied clinic course. Three types have been described based on effected gene...
Background: Mitochondrial disease has an estimated incidence of 1.6 per 5,000 live births and can affect nearly any organ system; however, the cardiac presentations clinical implications mitochondrial remain poorly understood. The purpose this study was to describe prevalence in a cohort patients with known compare outcomes between without disease. Methods: This retrospective performed at single pediatric tertiary-care hospital included genetic diagnosis that had least one encounter our...