A5052282386- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Issues in Pregnancy
- Liver Disease and Transplantation
- Cardiomyopathy and Myosin Studies
- Vascular Anomalies and Treatments
- Mechanical Circulatory Support Devices
- Infective Endocarditis Diagnosis and Management
- Organ Transplantation Techniques and Outcomes
- Cardiac Valve Diseases and Treatments
- Kawasaki Disease and Coronary Complications
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Adipose Tissue and Metabolism
- Congenital heart defects research
- Cardiovascular and Diving-Related Complications
- Heart Failure Treatment and Management
- Ultrasound in Clinical Applications
- Vascular anomalies and interventions
- Coronary Artery Anomalies
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Cardiovascular Conditions and Treatments
- Congenital Diaphragmatic Hernia Studies
University of Geneva
2011-2025
University Hospital of Geneva
2011-2025
Royal Children's Hospital
2017-2023
University of Lausanne
2020-2023
J.P. Morgan
2022
IRCCS Policlinico San Donato
2020-2021
Hôpital Beau-Séjour
2011-2017
Geneva College
2017
Hôpital de l'enfance
2012
RELX Group (Netherlands)
2012
Background: Cardiac injury and myocarditis have been described in adults with coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome 2 (SARS-CoV-2) infection children is typically minimally symptomatic. We report a series of febrile pediatric patients heart failure potentially associated SARS-CoV-2 the multisystem inflammatory as defined by US Centers for Disease Control Prevention. Methods: Over 2-month period, contemporary pandemic France Switzerland, we retrospectively...
The causes of cardiomyopathy in children are less well described than adults. We evaluated the clinical diagnoses and genetic childhood outcomes cascade testing family members.We recruited from a pediatric cardiology service or heart diseases clinic. performed Sanger, gene panel, exome genome sequencing classified variants for pathogenicity using American College Molecular Genetics Genomics guidelines.Cardiomyopathy was diagnosed 221 unrelated aged ≤18 years. Children mostly had hypertrophic...
Congenital portosystemic shunts are often associated with systemic complications, the most challenging of which liver nodules, pulmonary hypertension, endocrine abnormalities, and neurocognitive dysfunction. In present paper, we offer expert clinical guidance on management make recommendations regarding shunt closure follow-up.
ABSTRACT Objectives: Little is known about pancreatic fat accumulation and its possible associations with metabolic syndrome (MetS) glucose metabolism. The aim of the present study was to quantify fraction (PFF) in lean obese adolescents explore relation parameters. Methods: We recruited 25 24 adolescents. PFF visceral adipose tissue (VAT) were determined using magnetic resonance imaging. measured blood pressure, fasting glucose, insulin, liver enzymes, leptin, lipid levels. Obese subjects...
Obesity has been associated with increased bone mass, but the mechanisms involved are still poorly understood. We aimed to explore relation between mineral density and factors known influence formation in obese lean adolescents.We recruited 24 25 adolescents a case-control study. Total body (TB-BMD) z scores composition were determined using dual-energy x-ray absorptiometry. measured 25-hydroxyvitamin D (25-OH-D), glucose, insulin, leptin concentrations. Physical activity (PA) level was...
Aims A proportion of patients with pulmonary arterial hypertension associated congenital heart disease (PAH-CHD) do not fit in the current classification. We aimed to analyse applicability an adapted clinical classification PAH-CHD pediatric using TOPP-1 registry (Tracking Outcomes and Practice Pediatric Pulmonary Hypertension) focus on atrial septal defects (ASD) transposition great arteries (TGA). Methods results Hemodynamic data all TOPP cohort were reviewed. Patients classified according...
The treatment of complex transposition the great arteries with a ventricular septal defect and pulmonary stenosis/left outflow tract obstruction poses significant challenges. decision between performing Rastelli procedure, Nikaidoh procedure or double root rotation depends on cardiac anatomy, especially location defect, its spatial relationship arteries, presence straddling atrioventricular valve appreciation valve. In our centre, goal is to provide most physiologic repair tailored each...
Abstract Despite significant advances in knowledge and the development of guidelines, management hypoplastic left heart syndrome (HLHS) remains highly variable. A structured questionnaire was circulated across European Association Paediatric & Congenital Cardiology (AEPC) affiliated centres. The aims were to evaluate standards pre-operative assessment, types surgery, follow-up medical practices children with HLHS. Thirty-one centres from 20 countries completed survey. Delivery babies...
Portopulmonary hypertension is a rare but serious complication of portal or portosystemic shunting. an indication for liver transplantation shunt closure. However, contraindicated in patients with severe pulmonary arterial hypertension. Reported mortality rates are high children portopulmonary and there scarce recommendations on its management. Our aim was to report our real-world experience managing specialised centre. We describe series 6 Their median age at diagnosis 13 years (range...
TBX20 encodes a cardiac transcription factor that is associated with atrial septal defects. Recent studies implicate loss-of-function variants left ventricular non-compaction cardiomyopathy (LVNC), although clinical and genetic data in families are limited. We report four segregate LVNC. Genetic testing using genome or exome sequencing was performed index cases, were validated Sanger sequencing, cascade family members. A multi-exon deletion, small essential splice site variant nonsense found...
Lymphatic disorders such as protein-losing enteropathy, plastic bronchitis, and chylothorax are important complications of the Fontan circulation ultimately result in an increased risk early death. Several European centers now performing lymphatic procedures. The aim this study is to map extent these treatments provided across pediatric cardiology centers.
Background: In adults, epicardial adipose tissue (EAT) is associated with metabolic syndrome (MS) and coronary artery disease. EAT thickness increased in obese youth, but total volume its correlation cardiovascular risk factors have not been studied. Objectives: To determine adolescents association obesity factors. Methods: We performed a cross-sectional study including 48 pubertal (24 24 lean subjects, aged 13.6 ± 1.5 yr). as well visceral subcutaneous abdominal volumes were obtained by...