A5085579217- Chemical Synthesis and Characterization
- Organophosphorus compounds synthesis
- Boron Compounds in Chemistry
- Synthesis and Characterization of Heterocyclic Compounds
- RNA and protein synthesis mechanisms
- DNA and Nucleic Acid Chemistry
- Radioactive element chemistry and processing
- Metal complexes synthesis and properties
- Phosphorus compounds and reactions
- HIV/AIDS drug development and treatment
- Sirtuins and Resveratrol in Medicine
- Analytical chemistry methods development
- Adenosine and Purinergic Signaling
- Advanced biosensing and bioanalysis techniques
- Organoboron and organosilicon chemistry
- Plant Gene Expression Analysis
- Thallium and Germanium Studies
- RNA modifications and cancer
- Biochemical and biochemical processes
Institute of Bioorganic Chemistry, Polish Academy of Sciences
2018-2024
Umeå University
2024
University of Warsaw
2013
Abstract A sensitive voltammetric method (DPASV) was developed for the determination of Tl(I) and Tl(III) in plant extracts. To limit influence organic matrix on measurements, UV irradiation addition Amberlite XAD‐7 resin studied. The application 0.5 g allowed defining thallium speciation 10.0 mL a solution containing 0.20 Sinapis alba extract. quantification ng −1 found only 10 min preconcentration, is low enough to allow dilution sample before determination. procedure validated using...
Mechanistic and stereochemical aspects of the reaction boranephosphonate diesters with amines promoted by iodine were investigated. This is a complex, multistep that ultimately produces corresponding phosphoramidate via formal replacement borane group an amine moiety. We found correlation analysis that, contrary to literature report, whole transformation proceeded total inversion configuration at phosphorus center. Our study also showed instead postulated nucleophilic substitution iodide...
Boranephosphonate diesters react with heteroaromatic and certain tertiary amines in the presence of an oxidant (I2) to afford boron-modified phosphodiester analogues containing a P–B–N structural motif. Our multinuclear 31P 11B NMR spectroscopy studies lend support for two-step mechanism involving generation λ3-boranephosphonate intermediate that immediately coordinates amine solvent cage, leading B-pyridinium or B-ammonium boranephosphonate betaine derivatives. We found type used (e.g.,...
A simple and convenient synthetic protocols based on H-phosphonate chemistry have been developed for the preparation of nucleoside 5′-diphosphates. It consists oxidation silylated monoesters in pyridine with iodine to produce corresponding N-pyridiniumphosphonate intermediates, followed by their reactions orthophosphoric acid used as a nucleophile. The added value method is that substrates reaction, monoesters, can be prepared situ from nucleosides next step without isolation. procedure...
Abstract Boranephosphonate diesters react with pyridine and some tertiary amines in the presence of dimethoxytrityl chloride used as a borane hydride acceptor, to afford boron-modified phosphodiester analogues containing P-B-N structural motif. The reaction provides convenient entry pyridinium- ammoniumboranephosphonates derived from corresponding alkyl, aryl, or nucleoside boranephosphonate diesters. Some aspects synthetic protocol, mechanistic features related possible intermediate...
Two synthetic routes for the preparation of nucleoside selenophosphoramidates have been developed by using H-phosphonate derivatives as key substrates. The first method is a one-pot synthesis, which involves condensation an amine with monoesters, mediated coupling agent, followed oxidation elemental selenium (A). second approach makes use oxidative reaction H-phosphonoselenoate monoesters amines promoted iodine oxidizing agent (B). Both methods are efficient and experimentally simple, but...
It is known that cells contain various uncommon nucleotides such as dinucleoside polyphosphates (NpnN's) and adenosine 5'-phosphoramidate (NH2-pA) belonging to nucleoside 5'-phosphoramidates (NH2-pNs). Their cellular levels are enzymatically controlled. Some of them accumulated in under stress, therefore, they could act signal molecules. Our previous research carried out Arabidopsis thaliana grape (Vitis vinifera) showed NpnN's induced the expression genes phenylpropanoid pathway favored...
The most common type of modification a phosphorus center is the replacement one or two non-bridging atoms phosphate group with different heteroatoms (e.g., sulfur, selenium) groups methyl, borane). Such compounds are referred to as first generation nucleotide analogues. We were interested in exploring possibility further functionalizing present nucleoside phosphorothioates, phosphoroselenoate boranephosphonates create second analogues hopefully new biological properties. Here we report...
Correction to: Synthesis of Pyridiniumboranephosphonate Diesters and Related Compounds using Trityl Cation as a Borane Hydride AcceptorSynthesis 2021; 53(03): 509-517DOI: 10.1055/s-0040-1706569