A5021428184- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
University Hospital Cologne
2020-2022
University of Cologne
2020
<b>Background:</b> Obesity contributes to lung diseases and regeneration. Prior studies from our group showed that perinatal maternal obesity induces bronchial vascular remodeling in later life. However, the impact of on alveolarization alveolar regenerative niche remains uncertain. <b>Aims:</b> (1) To investigate formation epithelial type II cells (ATII) as progenitor cells; (2) study effect white adipose tissue (WAT) its adipocytokines ATII. <b>Methods:</b> 1) Female mice were fed with...
<b>Rationale:</b> Mechanical ventilation (MV) of premature infants often leads to Bronchopulmonary dysplasia (BPD), which is characterized by an impaired alveolarization and regeneration. Since prior studies from our group showed that activation inflammatory IL-6 signaling a key mechanism BPD, we hypothesized deficiency protects MV-induced lung growth arrest. <b>Methods:</b> IL‑6‑deficient mice (IL‑6<sup>-/-</sup>) wildtype controls (WT) were ventilated (21% O<sub>2</sub>) for 8 h at...