A5021455947- Species Distribution and Climate Change
- Neurobiology and Insect Physiology Research
- Environmental Toxicology and Ecotoxicology
- Nanoparticle-Based Drug Delivery
- Characterization and Applications of Magnetic Nanoparticles
- Zebrafish Biomedical Research Applications
- Circadian rhythm and melatonin
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Endoplasmic Reticulum Stress and Disease
- Iron oxide chemistry and applications
- Animal Virus Infections Studies
Universidade do Porto
2022-2024
Rede de Química e Tecnologia
2022-2024
The University of Texas at Austin
2021
KU Leuven
2021
ABSTRACT Three pathogenic human coronaviruses have emerged within the last 20 years, with SARS-CoV-2 causing a global pandemic. Although therapeutic antibodies targeting spike currently focus on poorly conserved receptor-binding domain, essential neutralizing epitopes more S2 domain may provide broader protection. We report an antibody binding epitope in pre-fusion core of MERS-CoV, SARS-CoV and domains. Antibody 3A3 binds conformational ~2.5 nM affinity neutralizes from SARS-CoV, variants...
Behavioural disruptions are sensitive indicators of alterations to normal animal physiology and can be used for toxicity assessment. The small vertebrate zebrafish is a leading model organism toxicological studies. ability continuously monitor the drugs, pollutants, or environmental changes over several days in have high practical application. Although video-recordings short-term behaviour, it challenging videorecord prolonged experiments (e.g. circadian behaviour days) because darkness...
Abstract Behavioural studies provide insights into normal and disrupted biological mechanisms. In many research areas, a growing spectrum of animal models—particularly small organisms—is used for high-throughput with infrared-based activity monitors, generating counts per time data. The freely available software to analyse such data, however, are primarily optimized drosophila circadian analysis. Researchers investigating other species or non-circadian behaviour would thus benefit from more...
Introduction: The inherent fluorescence properties of iron oxide nanoparticles (IONPs) were characterized, and their applicability for multiphoton imaging in cells was tested combination with magnetic resonance (MRI) capabilities. Methods: Superparamagnetic synthesized subsequently coated polyethylene glycol to make them water-dispersible. Further characterization the particles performed using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), dynamic light scattering...
Abstract Developmental diseases are challenging to investigate due their clinical heterogeneity and relatively low prevalence. The Wolcott-Rallison Syndrome (WRS) is a rare developmental disease characterized by skeletal dysplasia permanent neonatal diabetes loss-of-function mutations in the endoplasmic reticulum stress kinase PERK (EIF2AK3). lack of efficient less invasive therapies for WRS highlights need new animal models that replicate complex pathological phenotypes, while preserving...