A5030492277- Malaria Research and Control
- Mosquito-borne diseases and control
- HIV Research and Treatment
- Epigenetics and DNA Methylation
- interferon and immune responses
- T-cell and B-cell Immunology
- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Invertebrate Immune Response Mechanisms
- Trypanosoma species research and implications
- Complement system in diseases
University of Lisbon
2017-2023
Universidade do Porto
2022
Abstract Eukaryotes have canonical pathways for responding to amino acid (AA) availability. Under AA-limiting conditions, the TOR complex is repressed, whereas sensor kinase GCN2 activated. While these been highly conserved throughout evolution, malaria parasites are a rare exception. Despite auxotrophic most AA, Plasmodium does not either nor GCN2-downstream transcription factors. Ile starvation has shown trigger eIF2α phosphorylation and hibernation-like response, overall mechanisms...
Plasmodium replicates within the liver prior to reaching bloodstream and infecting red blood cells. Because clinical manifestations of malaria only arise during stage infection, a perception exists that infection does not impact disease pathology. By developing murine model where stages are uncoupled, we showed integration signals from both dictated mortality outcomes. This dichotomy relied on stage-dependent activation Vγ4+ γδ T Subsequent parasite loads their cytokine profiles, low...
For Plasmodium falciparum, the most widespread and virulent human malaria parasite, persistence depends on continuous asexual replication in red blood cells, while transmission requires their differentiation into non-replicating gametocytes that can infect mosquito vector. This decision is controlled by stochastic derepression of a heterochromatin-silenced locus encoding PfAP2-G, master transcription factor sexual differentiation. The frequency pfap2-g was shown to be responsive...
Abstract Eukaryotes have canonical pathways for responding to amino acid (AA) availability. Under AA-limiting conditions, the TOR complex is repressed, whereas sensor kinase GCN2 activated. While these been highly conserved throughout evolution, malaria parasites are a rare exception. Despite auxotrophic most AA, Plasmodium does not either nor GCN2-downstream transcription factors. Ile starvation has shown trigger eIF2α phosphorylation and hibernatory-like response, overall mechanisms...