A5027435531- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- Cystic Fibrosis Research Advances
- Psychosomatic Disorders and Their Treatments
- Long-Term Effects of COVID-19
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Inhalation and Respiratory Drug Delivery
- Cardiovascular and exercise physiology
- Protease and Inhibitor Mechanisms
- Pulmonary Hypertension Research and Treatments
- Child and Adolescent Psychosocial and Emotional Development
- Thermal Regulation in Medicine
- COVID-19 Clinical Research Studies
- Occupational and environmental lung diseases
- Medical Imaging and Pathology Studies
- Ultrasound in Clinical Applications
- Indoor Air Quality and Microbial Exposure
- Insect Resistance and Genetics
- Vasculitis and related conditions
- Delphi Technique in Research
- Allergic Rhinitis and Sensitization
- Fatty Acid Research and Health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
University of Parma
2015-2024
Ospedale di Parma
2014
State Key Laboratory of Respiratory Disease
2014
<b><i>Background:</i></b> In chronic obstructive pulmonary disease (COPD) patients, small-airway dysfunction (SAD) is considered a functional hallmark of disease. However, the exact role SAD in clinical presentation COPD not yet completely understood; moreover, it known whether may have relationship with impact <b><i>Objectives:</i></b> To evaluate prevalence among patients categorized by old and new GOLD classification to ascertain there...
Small airways are relevant to the pathophysiology of asthma. We investigated whether in asthmatic patients with normal forced expiratory volume 1st second (FEV(1)) values, impulse oscillometry system (IOS), as a measure small airway function, contributed additional information spirometry either at baseline or after bronchodilator, and it was related disease control. The fall resistance from 5 20 Hz (R5-R20) reactance (X5) by IOS measures function (forced flow 25-75% [FEF(25-75)] vital...
We investigated whether a relationship between small airways dysfunction and bronchial hyperresponsiveness (BHR), expressed both in terms of ease airway narrowing excessive bronchoconstriction, could be demonstrated asthma. 63 (36 F; mean age 42 yr ± 14) stable, mild-to-moderate asthmatic patients (FEV1 92% pred ±14; FEV1/FVC 75% 8) underwent the methacholine challenge test (MCT). The degree BHR was as PD20 (in μg) ∆FVC%. Peripheral resistance measured pre- post-MCT by impulse oscillometry...
We aimed at comparing exhaled and non-exhaled non-invasive markers of respiratory inflammation in patients with chronic obstructive pulmonary disease (COPD) healthy subjects define their relationships smoking habit. Forty-eight stable COPD who were ex-smokers, 17 current smokers, 12 smokers ex-smokers included a cross-sectional, observational study. Inflammatory outcomes, including prostaglandin (PG) E2 15-F2t-isoprostane (15-F2t-IsoP) concentrations breath condensate (EBC) sputum...
Our objective was to evaluate the efficacy of a standardised work-up in diagnosis pleural tuberculosis (TB) that included fibreoptic bronchoscopy and medical thoracoscopy. A consecutive series 52 TB patients observed during period 2001-2015 evaluated retrospectively. 20 females, mean (range) age 39.7 (18-74) years, 32 males, 45.75 (21-83) were (28 non-EU citizens (53.8%)). The infections established by identification (using stains, culture or molecular tests) Mycobacterium pleura, sputum...
Background. Fractional exhaled nitric oxide (FeNO) measurement is a reliable, noninvasive marker of airway inflammation. The use portable FeNO analyzers may enable the assessment inflammation in primary care. Objective. authors compared values obtained by new device (NObreath, Bedfont, UK) to those standard stationary analyzer (NIOX, Aerocrine, Sweden) large cohort asthmatic patients. Methods. One hundred and fifty-four (age range: 14–83 years, forced expiratory volume one second [FEV1]...
Background: Long-term sequelae, called Long-COVID (LC), may occur after SARS-CoV-2 infection, with unexplained dyspnoea as the most common symptom. The breathing pattern (BP) analysis, by means of ratio inspiratory time (TI) during tidal volume (VT) to total breath duration (TI/TTOT) and VT/TI ratio, could further elucidate underlying mechanisms in LC patients. Therefore, we analysed TI/TTOT at rest maximal exercise patients dyspnoea, compared a control group. Methods: In this...
Cystic fibrosis (CF) is an autosomal recessive disorder, caused by genetic mutations in CF transmembrane conductance regulator (CFTR) protein. Several reports have indicated the presence of specific fatty acid (FA) alterations patients, most notably decreased levels plasmatic and tissue docosahexaenoic (DHA), precursor Specialized Pro-resolving Mediators (SPMs). We hypothesized that imbalance between arachidonic (AA)- DHA-derived products could contribute to chronic pulmonary inflammation...
Background: There is no gold standard in diagnosing SAD. Indicators of SAD are considered: (a) a value &lt;65% predicted values two three measures, FEF25-75, FEF50 e FEF75 (FEF+); (b) FEV3/FEV6 &lt; LLN (FEV3/FEV6+); (c) an IOS R5-R20 &gt;0.07 kPa·s·L−1 (R5-R20+). Aim and Objectives: The aim the study was to ascertain, asthmatic patients, whether spirometry indicators agree detecting We also assessed relationship between clinical features asthma. Methods: prospectively recruited...
This observational cohort study investigated the relationship between alexithymia, coping strategies, anxiety, depression, pulmonary function, and disease control in bronchial asthma (BA) patients who attended a tertiary care center December 2010 November 2011. Participants (N = 117) were administered self-report scales measuring strategies. Pulmonary function expressed as forced expiratory volume first second (FEV1), vital capacity (FVC), flow rate over middle 50% of FVC (FEF25–75) as%...
Purpose: Smoking-induced bronchiolitis with progressive small airway dysfunction (SAD) is a leading cause of chronic obstructive pulmonary disease. We investigated the value using impulse oscillometry system (IOS) to detect SAD in asymptomatic smokers preserved spirometry. Patients and Methods: included 75 (37 females, mean age 47± 12 years, 26± 17 pack/year) spirometry [forced expiratory volume at 1st second (FEV1)/forced vital capacity (FVC) ≥ 0.70 normal FVC] 34 never-smokers (19 42± 15...
The management and treatment of Chronic Obstructive Pulmonary Disease (COPD) are based on a cutoff point either ≥ 10 the COPD Assessment Test (CAT) or 2 Medical Research Council (mMRC). Up to now, no study has assessed equivalence between CAT mMRC, as related exercise tolerance in COPD. aim this was investigate primary outcome relationship mMRC maximal capacity patients. We also evaluated secondary agreement (≥ 10) 2) categorize patients according their tolerance.118 consecutive (39...
<b><i>Background:</i></b> The role of an elevated body mass index (BMI) in asthma remains controversial. <b><i>Objectives:</i></b> To investigate the relationship between overweight (BMI >25 and ≤30), lung function, disease control, airway inflammation asthmatic population. <b><i>Methods:</i></b> We consecutively studied 348 patients (age 43 ± 16 years; 211 females). In all patients, BMI, spirometry, Asthma Control...
Background: Although the etiology and disease mechanisms of asthma alpha-1 antitrypsin deficiency (AATD) are distinct, several reports indicate that is common in AATD patients, however relationships between poorly described literature.Objectives: The aim study was to investigate a cohort outpatients affected by mild moderate clinical features may differentiate asthmatic patients with without mutation on SERPINA1 gene.Methods: Seven hundred thirty-five underwent quantitative analysis serum...
Lipoid pneumonia (LP) is a rare exogenous condition caused by inhalation or aspiration of lipid material into the lungs. It often associated with therapeutic use different types oil, and diagnosis based on demonstration lipid-laden macrophages in bronchoalveolar lavage fluid. We reported case 39-year-old male X-linked adrenoleukodystrophy who developed LP secondary to Lorenzo’s oil. To our knowledge, association between oil has never been literature.
In patients with chronic obstructive pulmonary disease (COPD), small airway dysfunction (SAD) is a key element and functional consequence of the pathology. The exact role SAD as specific 'pharmacological target' represents an important research topic. Our objective was to ascertain whether extra-fine formulation beclomethasone dipropionate/formoterol fumarate (BDP/FF) NEXThaler® 100/6 μg b.i.d. could improve and, consequently, quality life COPD patients. We enrolled severe airflow...
The ventilation heterogeneity (VH) is reliably assessed by the multiple-breath nitrogen washout (MBNW), which provides indices of conductive (Scond) and acinar (Sacin) VH as well lung clearance index (LCI), an global VH. can be alternatively measured poorly communicating fraction (PCF), that is, ratio total capacity body plethysmography to alveolar volume from single-breath diffusing measurement.Our objective was assess PCF MBNW in patients with asthma COPD compare parameters both patient...
The aim of the study was to investigate role alexithymia in bronchial asthma (BA) patients with low respiratory functioning hypothesizing that it could be used differentiate a group clinically significant anxiety and depressive symptoms. We also aimed whether associated reduced cognitive insight. Patients (n=153) were administered State- Trait Anxiety Inventory-State subscale, Beck Depression Inventory, Toronto Alexithymia Scale, Cognitive Insight Scale (BCIS). help functioning. Twenty-two...
Alpha 1 antitrypsin deficiency (AATD) is an autosomal codominant genetic condition that affects Caucasians of the European population due to presence a deficient allele SERPINA1 gene. A frequency about 1/5,000 individuals has been estimated in Italy.The aim study was evaluate distribution clinical manifestations severe and intermediate AATD geographic area around Parma Northern Italy.238 subjects were submitted molecular analysis gene, data on anthropometric variables, smoking habits, number...
Objectives: To compare the reliability of spirometry and body plethysmography in detecting restrictive lung disease clay excavation workers exposed to free crystalline silica (FCS). The exhaled breath condensate (EBC) biomarkers oxidative stress were also assessed order evaluate early damage. Methods: study involved 62 (58 males 4 females) at a company that extracts processes clay. Results: Body (total capacity below lower normal limit) respectively indicated pattern prevalence rates 22.6%...
<b><i>Background:</i></b> Alpha-1 antitrypsin deficiency (AATD) is a hereditary disorder involving lungs, characterized by low serum concentration of the protein alpha-1 (AAT) also called proteinase inhibitor (PI). Asthma common in AATD patients, but there are only few data on respiratory function asthmatic patients with AATD. <b><i>Objectives:</i></b> The aim study was to evaluate lung outpatients mutation <i>SERPINA1</i> gene...
<b>Background:</b> We investigated whether a relationship between small airways dysfunction and bronchodilator responsiveness occurs in COPD patients. <b>Methods:</b> studied 100 (20 F; mean age 68 yr ± 10) patients (FEV<sub>1</sub>: 55% pred 21; FEV<sub>1</sub>/FVC: 53% by impulse oscillometry system (IOS). Resistance at 5 20 Hz (R5 R20, kPa s l<sup>−1</sup>) the fall resistance from to (R5-R20) were used as indices of total, proximal peripheral airway resistance; reactance (X5, was also...
: In adults, 150 to 300 min a week of moderate-intensity physical activity is the recommended daily level maintain or improve fitness. subjects with chronic obstructive pulmonary disease (COPD), reductions in (DPA) amounts are related clinically significant outcomes. this study, we ascertain whether not COPD patients, when clustered into active (DPA ≥ 30 day, 5 days week) and inactive < week), may differ exercise capacity, as assessed by cardiopulmonary test (CPET).
Eosinophilic granulomatosis with polyangiitis (EGPA) is a multisystemic, immune-mediated disease that occurs in patients asthma and eosinophilia. It characterized by inflammation of small- medium-caliber blood vessels.