Inflammatory bowel disease (IBD) is considered to be the most common cause of vomiting and diarrhoea in dogs, German shepherd dog (GSD) particularly susceptible. The exact aetiology IBD unknown, however associations have been identified between specific single-nucleotide polymorphisms (SNPs) Toll-like receptors (TLRs) human IBD. However, date, no genetic studies undertaken canine aim this study was investigate whether TLR 2, 4 5 genes are associated with GSDs. Mutational analysis TLR2, TLR4...

Genetics are an important factor in the development of human inflammatory bowel disease (IBD); however, there is very little information available regarding role genetics canine IBD. The purpose this study was to gather about which breeds south‐eastern UK at a high risk for developing Determination such may help further genetic research complex disease. computer medical records Queen Mother Hospital Animals, Royal Veterinary College dating from August 1, 2003 December 31, 2009 were...

Single nucleotide polymorphisms (SNP) in the TLR5 gene have been associated with human inflammatory bowel disease (IBD) and animal models of this disease. We recently demonstrated a significant association between three non-synonymous SNPs canine IBD German shepherd dogs (GSDs). However, so far, no direct link these disturbance function was shown. In present study, we determined functional significance by transfecting identified risk-protective risk-associated haplotype into embryonic kidney...

Feline chronic enteropathies (FCE) are challenging to diagnose and monitor for progression response treatment. Fecal calprotectin might be a useful non-invasive marker evaluate clinical endpoints of therapeutic monitoring in FCE. We evaluated fecal concentrations cats with FCE before after initiation treatment comprised immunomodulation and/or dietary intervention. Included were 17 18 healthy controls. Clinical investigation cases included severity grading (feline enteropathy activity index,...

O bjectives : To investigate whether elevated canine pancreatic lipase immunoreactivity (CPLI) concentrations in dogs with inflammatory bowel disease (IBD) is associated a worse clinical outcome. M ethods Serum CPLI assays were performed on serum stored from cases diagnosed IBD. Thirty‐two results within the reference range designated as control group and 15 had above range. Clinical signs, age, amylase activities, albumin cobalamin concentrations, abdominal ultrasound examination,...

Inflammatory bowel disease (IBD) is thought to be the most common cause of vomiting and diarrhoea in dogs. Although IBD can occur any canine breed, certain breeds are more susceptible. We have previously shown that polymorphisms TLR4 TLR5 (toll-like receptor) genes significantly associated with German Shepherd dogs (GSDs). In order allow for development novel diagnostics therapeutics suitable all suffering from IBD, it would useful determine if described also other breeds. Therefore, aim...

Background Certain amino acids are decreased in humans with inflammatory bowel disease (IBD) and supplementation the same has shown beneficial effects animal models of IBD. Currently, acid status dogs protein‐losing enteropathy (PLE) is unknown. Hypothesis/Objective To determine if serum concentrations abnormal PLE correlated clinical laboratory variables outcome. Animals Thirty client‐owned diagnosed 12 apparently healthy seen at Bristol Veterinary School. Methods Retrospective study using...

Background Gall bladder mucoceles (GBM) are a leading cause of biliary disease in dogs with several breeds, including the Shetland Sheepdog, American Cocker Spaniel, Chihuahua, Pomeranian, and Miniature Schnauzer apparently predisposed. Objective To determine risk factors, clinical features, response to treatment GBM Border terriers (BT). Animals Medical records 99 (including 51 BT) an ultrasonographic (±histopathologic) diagnosis from three referral centers United Kingdom were collected. A...

Abstract Background Risk factors associated with negative outcomes in dogs protein‐losing enteropathy (PLE) are well documented. However, mortality before hospital discharge and risk not described. Hypothesis/Objectives Report the percentage of PLE that do survive to identify factors. Animals One‐hundred seven presented a referral diagnosed caused by inflammatory enteritis, intestinal lymphangiectasia or both. Methods Retrospective cross‐sectional study assessing records. Data on in‐hospital...

ABSTRACT Background Consumption of a high‐fat, high‐carbohydrate Western‐style diet (WD) associated with obesity and inflammation in humans has not been investigated dogs. Aims To determine the effects WD on inflammatory indices, microbiome, fecal bile acids (BAs) Animals Ten adult clinically healthy Methods A dietary trial compared two home‐prepared diets: high‐fiber, low‐fat control (CD) to containing macronutrient composition (low‐fiber, high fat). Dietary treatments were given...

Background Malnutrition is associated with increased risk of premature death in humans inflammatory bowel disease. Hypothesis/Objective To determine if historical, clinical, and laboratory markers malnutrition dogs at the time histologic diagnosis protein‐losing enteropathy (PLE) caused by chronic (CE) or lymphangiectasia are death. Animals Seventy‐one client‐owned diagnosed PLE. Methods The medical records were retrospectively searched for cases PLE, CE on basis histopathology intestinal...

Abstract Background Serum feline pancreatic lipase immunoreactivity (fPL) commonly is used in the assessment of sick cats suspected to have pancreatitis but its diagnostic utility debated. Objectives To evaluate Spec fPL test and selected serum biochemistry tests diagnosis cats. Animals Two hundred seventy‐four client‐owned presented a university teaching hospital United Kingdom, from April 2013 May 2017, which was measured. Methods Cats were classified into 1 4 groups based on clinical...

Clinical features of feline hepatocellular carcinoma (HCA) have been poorly characterized. In this retrospective study, we describe the signalment, clinical features, clinicopathologic parameters, imaging characteristics, hepatic mass size and lobe distribution, concurrent disorders, survival in 19 cats with HCA. HCA is a rare neoplasm elderly often associated weight loss, hyporexia, increased transaminase activities. Concurrent disorders (e.g., hyperthyroidism, inflammatory bowel disease,...

Abstract The effect of a hydrolyzed protein diet on the fecal microbiota has not been studied in feline chronic enteropathy (CE). Our study aimed to (1) compare cats with CE control no gastrointestinal signs and (2) determine whether this differs between dietary responders non-responders. microbiome (n = 36) showed decreased α-diversity terms genus richness ( P 0.04) increased β-diversity Bray–Curtis Dissimilarity < 0.001) compared 14). Clostridium was only genera significantly...

Obesity in cats is associated with metabolic abnormalities and increased susceptibility to diseases such as diabetes mellitus. Studies mouse models human beings have shown that probiotics can reduce food intake, promote weight loss improve profile. assessing the effects of on these same parameters are absent cats. Therefore, aim this study was determine if probiotic Enterococcus faecium strain SF68 dietary supplementation reduces promotes improves profile overweight obese without...

Dogs with inflammatory protein-losing enteropathy (iPLE) that attain remission may be at risk of subsequent relapse.To determine the incidence relapse iPLE in dogs have previously attained complete clinical and biochemical identify associated factors.Seventy-five client-owned diagnosed iPLE.Medical records based on histopathology intestinal biopsy specimens between March 2010 2020 were retrospectively reviewed. Variables recorded from time investigation histopathologic diagnosis follow-up...

Abstract Background The effect of assisted enteral feeding on treatment outcome in dogs with protein‐losing enteropathy (PLE) is unknown. Objectives To determine if inflammatory PLE that had an tube placed better vs without a tube. Animals Fifty‐seven PLE. Methods A retrospective study at UK referral hospital identified using standard diagnostic criterion. Positive was defined as survival greater than 6 months or death unrelated to and negative related within diagnosis. Several variables...

Objectives Feline chronic inflammatory enteropathy is an idiopathic disease with limited information on variables that might affect treatment outcome and survival. The aim of this study was to determine if clinicopathological were associated death due gastrointestinal in cats enteropathy. Materials Methods Three medical records databases retrospectively searched for diagnosed at the Royal Veterinary College between June 2008 November 2021. Intestinal biopsy specimens eligible cases...

Abstract Background Dogs with protein‐losing enteropathy (PLE) are at risk of developing a hypercoagulable state, but the prevalence hypercoagulability in dogs chronic enteropathies (CE) and normal serum albumin concentration is unknown. Hypothesis CE predisposed to state as assessed by thromboelastography (TEG) independent concentration. Methods gastrointestinal signs from suspected inflammatory between 2017 2019 were included. Thirty‐eight evaluated; every dog had CBC, biochemistry panel,...

Background Increased delivery of taurine‐conjugated bile acids to the distal bowel can lead dysbiosis resulting in colitis mouse models inflammatory disease. A similar situation also could occur cats with intestinal disease and might therefore result decreased whole‐body taurine concentration. Hypothesis/Objectives To determine whether whole‐blood concentrations are at time diagnosis correlate clinical laboratory variables. Animals Twenty‐one chronic enteropathy 7 neoplasia from University...

Dogs with protein-losing enteropathy (PLE) caused by inflammatory enteritis, intestinal lymphangiectasia, or both, have a guarded prognosis, death occurring as result of the disease in approximately 50% cases. Although dietary therapy alone is significantly associated positive outcome, there limited ability to differentiate between food-responsive (FR) PLE and immunosuppressant-responsive (IR) at diagnosis dogs. Our objective was determine if transfer learning computational approach image...